Endothelial stiffening in dyslipidemia

Master, Elizabeth Le; Levitan, Irena

doi:10.18632/aging.101778

Cited by 15 publications

(9 citation statements)

References 8 publications

(12 reference statements)

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“…The link between PWV and AIP supports the view that the calculation of AIP should be included in the everyday clinical evaluation of the risk of cardiovascular disease, especially due to the easy calculation of AIP from routine lipid profiles. It could be an effective predictive value to detect early vascular aging and subclinical atherosclerosis [ 119 , 120 ].…”

Section: Importance Of Analyzed Research In Routine Clinical Practicementioning

confidence: 99%

Arterial Stiffness Assessment by Pulse Wave Velocity in Patients with Metabolic Syndrome and Its Components: Is It a Useful Tool in Clinical Practice?

Starzak

Stanek

Jakubiak

et al. 2022

IJERPH

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Metabolic syndrome (MS) is not a single disease but a cluster of metabolic disorders associated with increased risk for development of diabetes mellitus and its complications. Currently, the definition of MS published in 2009 is widely used, but there are more versions of the diagnostic criteria, making it difficult to conduct scientific discourse in this area. Increased arterial stiffness (AS) can predict the development of cardiovascular disease both in the general population and in patients with MS. Pulse wave velocity (PWV), as a standard method to assess AS, may point out subclinical organ damage in patients with hypertension. The decrease in PWV level during antihypertensive therapy can identify a group of patients with better outcomes independently of their reduction in blood pressure. The adverse effect of metabolic disturbances on arterial function can be offset by an adequate program of exercises, which includes mainly aerobic physical training. Non-insulin-based insulin resistance index can predict AS due to a strong positive correlation with PWV. The purpose of this paper is to present the results of the review of the literature concerning the relationship between MS and its components, and AS assessed by PWV, including clinical usefulness of PWV measurement in patients with MS and its components.

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Section: Importance Of Analyzed Research In Routine Clinical Practicementioning

confidence: 99%

Arterial Stiffness Assessment by Pulse Wave Velocity in Patients with Metabolic Syndrome and Its Components: Is It a Useful Tool in Clinical Practice?

Starzak

Stanek

Jakubiak

et al. 2022

IJERPH

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“…An increase in pro-atherogenic LDL and its oxidative modifications (ox-LDL) is well known to be a crucial factor in endothelial damage, a key early step and a predictor of the development of AS ( 44 ). When the body is continuously exposed to high levels of LDL, inflammatory pathways in vascular endothelial cells are activated to increase local and systemic inflammation, endothelial cell dysfunction and apoptosis, and smooth muscle cell proliferation, resulting in foam cell formation and genesis of AS plaque ( 45 , 46 ).…”

Section: Discussionmentioning

confidence: 99%

A Prediction Equation to Estimate Vascular Endothelial Function in Different Body Mass Index Populations

Liu

Zhang

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveVascular endothelial dysfunction is considered an early predictor of endothelial injury and the initiating factor of atherosclerosis (AS). Brachial artery flow-mediated dilation (FMD) can detect endothelial injury early and provide important prognostic information beyond traditional cardiovascular (CV) risk factors. This study aimed to find the influencing factors of FMD and develop a simple prediction model in populations with different body mass indices (BMIs).MethodsIn total, 420 volunteers with different BMIs were recruited in our study. Subjects were randomly assigned to the derivation and validation cohorts (the ratio of the two was 1:2) with simple random sampling. The former was used for influencing factors searching and model construction of FMD and the latter was used for verification and performance evaluation.ResultsThe population was divided into two groups, i.e., 140 people in the derivation group and 280 people in the verification group. Analyzing in the training data, we found that females had higher FMD than males (p < 0.05), and FMD decreased with age (p < 0.05). In people with diabetes, hypertension or obesity, FMD was lower than that in normal individuals (p < 0.05). Through correlation analysis and linear regression, we found the main influencing factors of FMD: BMI, age, waist-to-hip radio (WHR), aspartate aminotransferase (AST) and low-density lipoprotein (LDL). And we developed a simple FMD prediction model: FMD = −0.096BMI−0.069age−4.551WHR−0.015AST−0.242LDL+17.938, where R2 = 0.599, and adjusted R2 = 0.583. There was no statistically significant difference between the actual FMD and the predicted FMD in the verification group (p > 0.05). The intra-class correlation coefficient (ICC) was 0.77. In a Bland-Altman plot, the actual FMD and the predicted FMD also showed good agreement. This prediction model had good hints in CV risk stratification (area under curve [AUC]: 0.780, 95 % confidence intervals [95% CI]: 0.708–0.852, p < 0.001), with a sensitivity and specificity of 73.8 and 72.1%, respectively.ConclusionsMales, older, obesity, hypertension, diabetes, smoking, etc. were risk factors for FMD, which was closely related to CV disease (CVD). We developed a simple equation to predict FMD, which showed good agreement between the training and validation groups. And it would greatly simplify clinical work and may help physicians follow up the condition and monitor therapeutic effect. But further validation and modification bears great significance.

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“…Obesity directly contributes to the incidence of cardiovascular risk factors, such as dyslipidemia, type 2 diabetes, and hypertension [19]. Dyslipidemia may cause endothelial dysfunction, which is a key early step in the development of atherosclerosis [20]. GLP-1-based therapeutic modalities may improve vascular endothelial dysfunction in obesity [6][7][8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

Sitagliptin via the activation of AMPK/eNOS signaling improves vascular endothelial function by suppressing Creb5/lncRNA ENSMUST00000213271 axis in obese mice

Zong

Wang

Zhang

et al. 2022

Preprint

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Purpose This study aimed to investigate whether sitagliptin, a dipeptidyl peptidase-4 inhibitor, improved endothelial function by modulating lncRNAs in obese mice and clarify the underlying molecular mechanism. Methods Male C57BL/6J mice were fed with high-fat diet for four months to induce obesity and some obese mice were treated with sitagliptin for the last one month. Levels of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and glucagon-like peptide-1 (GLP-1) in plasma were detected by ELISA. LncRNA expression profile was analyzed via microarray. Aortic relaxations were examined by myograph. Protein expressions and phosphorylations were determined by Western blot. The differentially expressed lncRNAs were validated by qRT-PCR. Results Levels of TC and LDL were increased, concentrations of HDL and GLP-1 were decreased, and aortic endothelium-dependent relaxations were impaired in obese mice; sitagliptin reversed all above effects. Moreover, the altered expression profile of lncRNAs in the obese mouse aortae could be modulated by sitagliptin. qRT-PCR showed that lncRNA ENSMUST00000213271 was up-regulated in obese mouse aortae and endothelial cells but could be down-regulated by sitagliptin, which was consistent with microarray analysis. Importantly, we first revealed the regulatory effect of Creb5 on lncRNA ENSMUST00000213271. Furthermore, knockdown of either Creb5 or lncRNA ENSMUST00000213271 restored the activation of AMPK/eNOS in obese mouse aortic endothelial cells. Conclusion: Our results elucidate that sitagliptin ameliorated endothelial dysfunction by suppressing Creb5/lncRNA ENSMUST00000213271 and subsequently restoring AMPK/eNOS activation in obese mice. This study will provide the new evidence for the benefits of GLP-1 against vasculopathy in obesity.

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Endothelial stiffening in dyslipidemia

Cited by 15 publications

References 8 publications

Arterial Stiffness Assessment by Pulse Wave Velocity in Patients with Metabolic Syndrome and Its Components: Is It a Useful Tool in Clinical Practice?

Arterial Stiffness Assessment by Pulse Wave Velocity in Patients with Metabolic Syndrome and Its Components: Is It a Useful Tool in Clinical Practice?

A Prediction Equation to Estimate Vascular Endothelial Function in Different Body Mass Index Populations

Sitagliptin via the activation of AMPK/eNOS signaling improves vascular endothelial function by suppressing Creb5/lncRNA ENSMUST00000213271 axis in obese mice

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