Endothelial Nitric Oxide Synthase Gene Polymorphism Relationship With Semen Parameters and Oxidative Stress in Infertile Oligoasthenoteratozoospermic Men

Mostafa, Taymour; Rashed, Laila Ahmed; Nabil, Nashaat; Fouad, Hanan; Sabry, Dina; El-Saied, Dalia M.

doi:10.1016/j.urology.2015.01.023

Cited by 13 publications

(13 citation statements)

References 26 publications

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“…Up to date, some single-nucleotide polymorphisms (SNPs) have been identified to involve in sperm defects and male infertility in ethnic populations. Polymorphisms T786C and G894T of eNOS were reported to decrease sperm motility and quantity by increasing the seminal oxidative stress in Egyptian infertile male population [90]. Similar results of G894T were reported in Italian and Iranian infertile male populations [91,92], and this SNP also found to be associated with higher level of sperm DNA fragmentation in Chinese infertile males [93].…”

Section: Single-nucleotide Polymorphisms Of Nos and Male Infertilitysupporting

confidence: 67%

Nitric Oxide Synthase in Male Urological and Andrologic Functions

Yu¹,

Li²,

Li³

et al. 2017

Nitric Oxide Synthase - Simple Enzyme-Complex Roles

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Nitric oxide (NO), a crucial signaling molecule, is synthesized by the nitric oxide synthase (NOS) enzyme. The significant effects of NOS are under exploration, and the roles of potential therapy targets for diseases of NOS are widely accepted. In this chapter, we summarized the important roles of NOS mainly on pathogenesis of prostate diseases, male infertility, erectile dysfunction and, addition, the potential therapeutic efficacies of NOS for those diseases.

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Section: Single-nucleotide Polymorphisms Of Nos and Male Infertilitysupporting

confidence: 67%

Nitric Oxide Synthase in Male Urological and Andrologic Functions

Yu¹,

Li²,

Li³

et al. 2017

Nitric Oxide Synthase - Simple Enzyme-Complex Roles

View full text Add to dashboard Cite

show abstract

“…Several eNOS alleles have been associated with sperm defects in various ethnic populations. In Egyptian infertile oligoasthenoteratozoospermic men, a significant relationship between eNOS polymorphisms T786C and G894T with decreased sperm parameters and increased seminal oxidative stress was observed [ 46 ]. In an Italian population, the eNOS 894G>T variant was associated with asthenozoospermia and sperm motility [ 48 ].…”

Section: Genetic Variations In Antioxidant Genes Associated With Mmentioning

confidence: 99%

Variations in Antioxidant Genes and Male Infertility

Huang

2015

BioMed Research International

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Oxidative stress and reactive oxygen species (ROS) are generated from both endogenous and environmental resources, which in turn may cause defective spermatogenesis and male infertility. Antioxidant genes, which include catalase (CAT), glutathione peroxidase (GPX), glutathione S-transferase (GST), nitric oxide synthase (NOS), nuclear factor erythroid 2-related factor 2 (NRF2), and superoxide dismutase (SOD), play important roles in spermatogenesis and normal sperm function. In this review, we discuss the association between variations in major antioxidant genes and male infertility. Numerous studies have suggested that genetic disruption or functional polymorphisms in these antioxidant genes are associated with a higher risk for male infertility, which include low sperm quality, oligoasthenoteratozoospermia, oligozoospermia, and subfertility. The synergistic effects of environmental ROS and functional polymorphisms on antioxidant genes that result in male infertility have also been reported. Therefore, variants in antioxidant genes, which independently or synergistically occur with environmental ROS, affect spermatogenesis and contribute to the occurrence of male infertility. Large cohort and multiple center-based population studies to identify new antioxidant genetic variants that increase susceptibility to male infertility as well as validate its potential as genetic markers for diagnosis and risk assessment for male infertility for precise clinical approaches are warranted.

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“…Mutations of autosomal genes are also closely related to male infertility; however, the underlying molecular mechanisms are still unknown [3,4]. Various studies have shown the association between different genotypes of cytokines encoding genes and infertility [5][6][7][8]. Tumor necrosis factor alpha (TNF-α) is a cytokine that is normally present in the male genital tract.…”

Section: Introductionmentioning

confidence: 99%

Association of the -308G/A Polymorphism of TNF-α Gene with Some Semen and Sperm Parameters in Men with Infertility

Najafipour

Moghbelinejad

Aboutorabi

et al. 2019

J. Qazvin Univ. Med. Sci.

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Background The tumor necrosis factor alpha (TNF-α) gene is a cytokine involved in systemic inflammation. Results of the association of its polymorphisms with infertility in men are controversial. Objective The aim of this study was to evaluate the association of-308G/A polymorphism in TNF-α gene with different parameters of semen and sperm in infertile men. Methods Participants were 210 men with infertility and 120 controls. The polymorphism evaluation was performed by sequencing method. In order to assess oxidative stress and apoptosis in men with-308G/A polymorphism, malondialdehyde and caspase-9 values were measured. The sperm DNA damage and sex chromosomes aneuploidy were also measured in these patients. Findings A significant higher frequency of A allele of-308G/A polymorphism was observed in men with oligoasthenospermia (P=0.01). In semen samples of the men with AA genotype, there was significantly high level of malondialdehyde and caspase-9 (P<0.0001). We also observed higher frequency of sperm DNA damage (P=0.0001) and sex chromosome disomy type XY (P=0.0001) in sperm samples of men with AA genotype of-308G/A polymorphism. Furthermore, there was a significant correlation between sex chromosome aneuploidy and sperm DNA damage in sperms of men with this polymorphism (R=0.72, P=0.048). Conclusion-308G/A polymorphism of TNF-α gene has association with decreased sperm parameters, increased oxidative stress, higher sperm DNA damage and sex chromosome aneuploidy which can affect infertility.

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Endothelial Nitric Oxide Synthase Gene Polymorphism Relationship With Semen Parameters and Oxidative Stress in Infertile Oligoasthenoteratozoospermic Men

Cited by 13 publications

References 26 publications

Nitric Oxide Synthase in Male Urological and Andrologic Functions

Nitric Oxide Synthase in Male Urological and Andrologic Functions

Variations in Antioxidant Genes and Male Infertility

Association of the -308G/A Polymorphism of TNF-α Gene with Some Semen and Sperm Parameters in Men with Infertility

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