Endothelial function in normal and pathological conditions

Пизов, А. В.; Пизов, Н. А.; Skachkova, О.А.; Пизова, Н. В.

doi:10.21518/2079-701x-2019-6-154-159

Cited by 12 publications

(3 citation statements)

References 54 publications

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“…Кроме того, при гиперхолестеринемии в сосудистой стенке уменьшается образование NO за счёт накопления ингибиторов NO-синтазы, таких как L-глутамин, асимметричный диметиларгинин, а также уменьшения концентрации кофактора NO-синтазы тетрагидробиоптерина [8].…”

Section: Discussionunclassified

Effect of oxidative stress on endothelium in patients with heart failure and type 2 diabetes mellitus

Mammadova

кызы²

2020

Kazan Med J

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Aim. To estimate the severity of endothelial dysfunction and effects of nitric oxide, thiol status and cystatin on the progression of chronic heart failure and chronic heart failure in type 2 diabetes mellitus. Methods. 80 patients (men and women) with chronic heart failure were included. All patients were divided into two groups: the first group 39 patients with chronic heart failure, the second 41 people with chronic heart failure and type 2 diabetes mellitus. The control group consists of 20 healthy donors. To obtain statistically significant differences with the control group the minimum sample size for observations was determined based on the target variance of a small sample (n=10). The lipid profile and carbohydrate metabolism, endothelin-1, cystatin, nitric oxide were evaluated. Statistical processing was performed using Microsoft Office Excel and IBM SPSS Statistics 20 software. Results. Changes in lipid metabolism were found in both groups, while an increase in carbohydrate metabolism was observed in patients with chronic heart failure with type 2 diabetes mellitus. Under conditions of oxidative stress in patients with chronic heart failure, a decrease in the content of thiol status and an increase in the amount of nitric oxide in the blood serum were recorded. The endothelin-1 level was elevated, particularly in the second group, which indicates a more serious endothelial dysfunction with increased glucose content in patients with chronic heart failure. Conclusion. The level of cystatin C as an atherogenic risk factor was equally increased in the studied patients, possibly it affected by the rate of disease progression; feasible to use these markers to detect the progression of chronic heart failure in the early stages.

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Section: Discussionunclassified

Effect of oxidative stress on endothelium in patients with heart failure and type 2 diabetes mellitus

Mammadova

кызы²

2020

Kazan Med J

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“…The capillary network with its complex system of regulation is composed of endothelium, which plays, as established by numerous studies, a role that is far from passive [4,27,28]. The independent role of the endothelium in the regulation of vascular tone was first reported in a paper by Furchgott and Zawadzki published in Nature in 1980 [29].…”

Section: Introductionmentioning

confidence: 99%

Correlation between the Capillary Blood Flow Characteristics and Endothelium Function in Healthy Volunteers and Patients Suffering from Coronary Heart Disease and Atrial Fibrillation: A Pilot Study

Ermolinskiy,

Gurfinkel,

Sovetnikov

et al. 2023

Life

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Coronary heart disease (CHD) and atrial fibrillation (AF) pose significant health risks and require accurate diagnostic tools to assess the severity and progression of the diseases. Traditional diagnostic methods have limitations in providing detailed information about blood flow characteristics, particularly in the microcirculation. This study’s objective was to examine and compare the microcirculation in both healthy volunteers and patient groups with CHD and AF. Furthermore, this study aimed to identify a relationship between blood microcirculation parameters and endothelial function. Digital capillaroscopy was employed to assess the microcirculation parameters, for example, such as capillary blood flow velocity, the size of red blood cell aggregates, and the number of aggregates per min and per running mm. The results indicate significant alterations in blood flow characteristics among patients with CHD and AF compared to healthy volunteers. For example, capillary blood flow velocity is statistically significantly decreased in the case of CHD and AF compared to the healthy volunteers (p < 0.001). Additionally, the correlation between the measured parameters is different for the studied groups of patients and healthy volunteers. These findings highlight the potential of digital capillaroscopy as a non-invasive tool for evaluating blood flow abnormalities (red blood cell aggregates and decreased capillary blood flow velocity) in cardiovascular diseases, aiding in early diagnosis and disease management.

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“…Он транспортирует FVIII к месту повреждения стенки сосуда. При стимуляции эндотелия повышается уровень vWF и Р-селектина [2].…”

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Effect of minimally invasive extracorporeal circulation on endothelial dysfunction in cardiac surgery patients

et al. 2020

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Aim. To assess the changes in endothelial dysfunction in patients undergoing cardiac surgery with minimally invasive extracorporeal circulation (MiECC). Methods. The study included 50 patients who were undergoing coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB). The patients were divided assigned to either a minimally invasive cardiopulmonary bypass system (group 1, n=15) or standard extracorporeal circuit (group 2, n=35). Changes in the laboratory parameters were assessed 5 times: before the operation, 5 minutes after protamine sulfate administration, 12 hours after the operation, 7 days after the patient's discharged from the hospital and one month after the operation. The activity of von Willebrand factor, factor VIII, and the number of activated platelets were examined in all patients in venous blood. Results. After protamine sulfate administration, the activity of von Willebrand factor was increased to 164% in the group 1, and up to 193% in the group 2, with a tendency to increase the indicator after 12 hours. The peak of endothelial dysfunction, with the growth of von Willebrand factor and factor VIII, occurs on the 7th day after the operation. In patients of the group with MiECC, von Willebrand factor activity was decreased at the hospital discharge and returned to normal in 1 month. The number of activated platelets increases mainly in group 2 (6% versus 4% in group 1, p=0.29). The expression of P-selectin was significantly higher in group 2 at the hospital discharge (5.5% versus 3.1% in group 1, p 0.001), and in 1 month (4.5% versus 2.3% in group 1, p 0.001). Conclusion. In patients with minimally invasive cardiopulmonary bypass, platelet activation decreases, endothelial dysfunction, accompanied by an increase in the von Willebrand factor and factor VIII activity, is less pronounced; the seventh day after surgery is a period of the high risk of thrombogenic complications.

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Endothelial function in normal and pathological conditions

Cited by 12 publications

References 54 publications

Effect of oxidative stress on endothelium in patients with heart failure and type 2 diabetes mellitus

Effect of oxidative stress on endothelium in patients with heart failure and type 2 diabetes mellitus

Correlation between the Capillary Blood Flow Characteristics and Endothelium Function in Healthy Volunteers and Patients Suffering from Coronary Heart Disease and Atrial Fibrillation: A Pilot Study

Effect of minimally invasive extracorporeal circulation on endothelial dysfunction in cardiac surgery patients

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Endothelial function in normal and pathological conditions

Cited by 12 publications

References 54 publications

Effect of oxidative stress on endothelium in patients with heart failure and type 2 diabetes ­mellitus

Effect of oxidative stress on endothelium in patients with heart failure and type 2 diabetes ­mellitus

Correlation between the Capillary Blood Flow Characteristics and Endothelium Function in Healthy Volunteers and Patients Suffering from Coronary Heart Disease and Atrial Fibrillation: A Pilot Study

Effect of minimally invasive extracorporeal circulation on endothelial dysfunction in cardiac ­surgery patients

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Effect of oxidative stress on endothelium in patients with heart failure and type 2 diabetes mellitus

Effect of oxidative stress on endothelium in patients with heart failure and type 2 diabetes mellitus

Effect of minimally invasive extracorporeal circulation on endothelial dysfunction in cardiac surgery patients