Endoscopic Fluorescence Detection of Intraepithelial Neoplasia in Barrett's Esophagus after Oral Administration of Aminolevulinic Acid

Stepinac, Thomas; Felley, Christian; Jornod, Philippe; Lange, Norbert; Gabrecht, Tanja; Fontolliet, C; Grosjean, Pierre; vanMelle, G.; Bergh, Hubert van den; Monnier, P; Wagnières, Georges; Dorta, Gian

doi:10.1055/s-2003-41514

Cited by 25 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Imaging systems for fluorescence of surfaces have of course been studied for many years, and endoscopically coupled systems for fluorescence bronchoscopy and laryngeal screening of malignancy have been studied extenstively by Xillix Inc. (6, 25), and competing systems (26). Experimental systems for colonoscopy (27, 5), esophageal studies (28, 29), and intrasurgical use have all be developed. The intrasurgical systems have been stimulated by the approval of fluorescence guided resection techniques for Glioma tumors (12, 30, 31).…”

Section: Methodsmentioning

confidence: 99%

Fluorescent Molecular Imaging and Dosimetry Tools in Photodynamic Therapy

Pogue

Samkoe

Gibbs-Strauss

et al. 2010

Methods in Molecular Biology

View full text Add to dashboard Cite

Measurement of fluorescence and phosphorescence in vivo is readily used to quantify the concentration of specific species that are relevant to photodynamic therapy. However, the tools to make the data quantitatively accurate vary considerably between different applications. Sampling of the signal can be done with point samples, such as specialized fiber probes or from bulk regions with either imaging or sampling, and then in broad region image-guided manner. Each of these methods is described below, the application to imaging photosensitizer uptake is discussed, and developing methods to image molecular responses to therapy are outlined.

show abstract

Section: Methodsmentioning

confidence: 99%

Fluorescent Molecular Imaging and Dosimetry Tools in Photodynamic Therapy

Pogue

Samkoe

Gibbs-Strauss

et al. 2010

Methods in Molecular Biology

View full text Add to dashboard Cite

show abstract

“…Stepinac et al (76) performed a similar study investigating the fluorescence detection of dysplasia and early cancer in Barrett's esophagus using 20 mg/kg of 5ALA vs. conventional random four-quadrant biopsy. Twenty-eight patients with known Barrett's esophagus were selected for the study.…”

Section: Gastrointestinal Surgerymentioning

confidence: 99%

“…The optimal dosing of 5ALA in the upper and lower GI tract did not vary significantly from that which was historically used in non-GI related malignancies. Since its earlier application for the photodiagnosis of colorectal (72, 73) and esophageal carcinoma (75, 76), oral administration of 5 and 10 mg/kg, respectively, demonstrated superior sensitivity and specificity in identifying neoplastic tissue on par with that of tradition biopsy-based surveillance methods. Oral administration of even greater amounts of 5ALA up to 1 g for its more recent gastric and hepatic applications (77–80), including the fluorescence of post-resection bile leaks, has shown equal efficacy.…”

Section: Gastrointestinal Surgerymentioning

confidence: 99%

Delta-Aminolevulinic Acid-Mediated Photodiagnoses in Surgical Oncology: A Historical Review of Clinical Trials

et al. 2019

View full text Add to dashboard Cite

Fluorescence imaging is an emerging clinical technique for real-time intraoperative visualization of tumors and their boundaries. Though multiple fluorescent contrast agents are available in the basic sciences, few fluorescence agents are available for clinical use. Of the clinical fluorophores, delta aminolevulinic acid (5ALA) is unique for generating visible wavelength tumor-specific fluorescence. In 2017, 5ALA was FDA-approved for glioma surgery in the United States. Additionally, clinical studies suggest this agent may have utility in surgical subspecialties outside of neurosurgery. Data from dermatology, OB/GYN, urology, cardiothoracic surgery, and gastrointestinal surgery show 5ALA is helpful for intraoperative visualization of malignant tissues in multiple organ systems. This review summarizes data from English-language 5ALA clinical trials across surgical subspecialties. Imaging systems, routes of administration, dosing, efficacy, and related side effects are reviewed. We found that modified surgical microscopes and endoscopes are the preferred imaging devices. Systemic dosing across surgical specialties range between 5 and 30 mg/kg bodyweight. Multiple studies discussed potential for skin irritation with sun exposure, however this side effect is infrequently reported. Overall, 5ALA has shown high sensitivity for labeling malignant tissues and providing a means to visualize malignant tissue not apparent with standard operative light sources.

show abstract