Endophytic Mycoflora from Mace and Seed of Nutmeg (Myristica fragrans Houtt) as a Source of Antifungal Compounds

Abstract

The nutmeg extract had been recognized as the source of antioxidant and antimicrobial activity. The aims of this study were to obtain endophytic fungi isolated from the mace and seed of Nutmeg (Myristica fragrans Houtt) and to determine antifungal activity of those isolates. Microbiol routine assay were conducted and it consists of three stages, namely isolation of endophytic fungi, identification of fungus and antifungal activity test by using dual culture. Sixteen endophytic fungus isolates were found in this study. Those are identified as Alternaria sp (BPB 1.

The antioxidant activity of endophytic fungal extract of nutmeg plant (Myristica fragrans Houtt.) from Cimande West Java, Indonesia

“…Indonesia is the world's leading producer of nutmeg [4,5]. Many studies on the bioactive properties of nutmeg have indicated that it has anti-diabetic, antibacterial, antifungal, anticonvulsant, anti-inflammatory, antioxidant, anticancer, and other benefits [6][7][8][9]. However, rapid population growth, industrialization, global IOP Publishing doi:10.1088/1755-1315/1271/1/012063 2 climate change, and exploiting and utilizing medicinal plants have mainly contributed to their extinction [10].…”

“…One approach that has been developed is to use endophytic fungi to produce bioactive components similar to those found in the host plant [11] Nearly 200 isolates of endophytic fungi were obtained from the pericarp, leaf, and nutmeg seeds of Bogor, West Java, Indonesia [12]. Endophytic fungi isolated from nutmeg mace and seeds have antifungal activity [6]. The medium used to grow endophytes impacts secondary metabolite production and biological activity [13].…”