Endophytic fungi with anti-microbial, anti-cancer and anti-malarial activities isolated from Thai medicinal plants

Wiyakrutta, Suthep; Sriubolmas, Nongluksna; Panphut, Wattana; Thongon, Nuntawan; Danwisetkanjana, Kannawat; Ruangrungsi, Nijsiri; Meevootisom, Vithaya

doi:10.1023/b:wibi.0000023832.27679.a8

Cited by 153 publications

(74 citation statements)

References 20 publications

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“…Extracts of 92 isolates could inhibit Mycobacterium tuberculosis, while 6 extracts inhibited Plasmodium falciparum. Strong anti-viral activity against Herpes simplex virus type 1 was observed in 40 isolates (Wiyakrutta et al 2004). …”

Section: Significance Of Endophytic Microorganismsmentioning

confidence: 99%

Bioactive secondary metabolites produced by microorganisms associated with plants

Firáková

Šturdíková

Múčková³

2007

Biologia

250

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Abstract:In the past few decades groups of scientists have focused their study on relatively new microorganisms called endophytes. By definition these microorganisms, mostly fungi and bacteria, colonise the intercellular spaces of the plant tissues. The mutual relationship between endophytic microorganisms and their host plants, taxanomy and ecology of endophytes are being studied. Some of these microorganisms produce bioactive secondary metabolites that may be involved in a host-endophyte relationship. Recently, many endophytic bioactive metabolites, known as well as new substances, possesing a wide variety of biological activities as antibiotic, antitumor, antiinflammatory, antioxidant, etc. have been identified. The microorganisms such as endophytes may be very interesting for biotechnological production of bioactive substances as medicinally important agents. Therefore the aim of this review is to briefly characterize endophytes and summarize the structuraly different bioactive secondary metabolites produced by endophytic microorganisms as well as microbial sources of these metabolites and their host plants.

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Section: Significance Of Endophytic Microorganismsmentioning

confidence: 99%

Bioactive secondary metabolites produced by microorganisms associated with plants

Firáková

Šturdíková

Múčková³

2007

Biologia

250

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“…Medicinal plants have been recognized as a repository of fungal endophytes with novel metabolites of pharmaceutical importance (Strobel et al 2004, Wiyakrutta et al 2004, Kumar et al 2005, Tejesvi et al 2007. Plant with pharmaceutical importance is being exploited because of their healing properties.…”

Section: Introductionmentioning

confidence: 99%

The molecular phylogeny and taxonomy of endophytic fungal species from the leaves of Vitex negundo L.

Ramesh¹

2017

SIF

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Enormous fungal species live within the healthy plant tissues, some of which presumably occur in a symbiotic association with host. Some fungal endophytes are widespread and can be found in many different plant species, whereas others are highly specific to single hosts. In this study, we isolated three endophytic fungi from the medicinal plant Vitex negundo. They were identified based on morphological characteristics such as size, shape, and colour of the spore and it was reinforced by 18s rRNA gene sequence analysis. The phylogenetic tree showed that C. gloeosporioides VN1 and Pestalotiopsis virgatula VN2 were closely relationship between. But they were not closely relationship between the other endophytic fungal species that were obtained from geographically different part of the world. This aspect can be further explored to understand the relationships between plant hosts and their fungal endophyte.

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“…Desta forma, a utilização da ecologia na prospecção de microrganismos de interesse biotecnológico isolados de solos e de plantas medicinais, tornou-se mais frequente e vem mostrando a descoberta de novos metabólitos bioativos (Strobel & Daisy, 2003;Wiyakrutta et al, 2004;Li et al, 2005).…”

Section: Introductionunclassified

Atividade antifúngica e cinética de morte microbiana de extratos obtidos de Streptomyces spp. isolados de solos paraibanos

Oliveira¹,

Lima²,

Souza³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:Foram coletadas sessenta e oito amostras em diferentes solos paraibanos, com o isolamento de quarenta e nove cepas de Streptomyces spp. Após triagem antimicrobiana, por meio da técnica de difusão em meio sólido com blocos de agar, foram preparados os extratos dos microrganismos produtores de metabólitos bioativos, respectivamente cepas SP1 e SP3, e em seguida avaliados quanto a atividade antifúngica frente a espécies de fungos filamentosos de origem clínica e ATCC. O antagonismo foi determinado através dos ensaios de difusão com discos em meio sólido, microdiluição e cinética de morte microbiana. Os halos de inibição obtidos a partir dos extratos Sp-1 e Sp-3 apresentaram efeito antagônico com valores superiores aos halos de inibição promovidos pela droga controle, frequentemente utilizada na terapêutica antifúngica. Os resultados das concentrações inibitórias mínimas na microdiluição foram expressivos com valores fungicidas variando entre 10 mg e 0,078125 mg. Na cinética de morte microbiana, as atividades dos extratos Sp-1 e Sp-3 resultaram em dados estatisticamente significativos frente às cepas testes.Unitermos: Streptomyces, extratos, atividade antifúngica, cinética.ABSTRACT: "Antifungal activity and kinetics of microbial death of extracts obtained from Streptomyces spp. isolated from paraibano soils". Sixty eight samples were collected in different soils of Paraiba, with the isolation of forty nine strains of Streptomyces spp. After screening antimicrobial followed the method of diffusion in solid medium with agar block, the extracts were prepared from microorganism producers of bioactive metabolites, respectively strains SP1 and SP3, and then evaluated for antifungal activity against strains of filamentous fungi of clinical origin and ATCC. The antagonism was determined through testing of diffusion disc in solid medium, microdilution and kinetics of microbial death. The inhibition zones obtained from extracts of Sp-1 and Sp-3 showed antagonistic effect with values greater than the halos of inhibition promoted by the drug control, often used in antifungal therapy. The results of minimum inhibitory concentrations in microdilution were significant with fungicide values ranging between 10 mg and 0.078125 mg. In the kinetics of microbial death, the activities of the extracts Sp-1 and Sp-3 resulted in statistically significant data front of strains tested.

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Endophytic fungi with anti-microbial, anti-cancer and anti-malarial activities isolated from Thai medicinal plants

Cited by 153 publications

References 20 publications

Bioactive secondary metabolites produced by microorganisms associated with plants

Bioactive secondary metabolites produced by microorganisms associated with plants

The molecular phylogeny and taxonomy of endophytic fungal species from the leaves of Vitex negundo L.

Atividade antifúngica e cinética de morte microbiana de extratos obtidos de Streptomyces spp. isolados de solos paraibanos

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