Endophthalmitis Isolates and Antibiotic Susceptibilities: A 10-Year Review of Culture-Proven Cases

Carifi, Gianluca; Zygoura, Vasiliki; Pitsas, Christos; Kopsachilis, Nikolaos

doi:10.1016/j.ajo.2013.09.007

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…The sensitivity of levofloxacin to gram-positive bacteria was disclosed to be as high as 82.3%-96.8% 19 , 20 in southern China and 77.5% in Miami. 22 In this study, however, it was only 51.67%, which was much lower than gatifloxacin. Therefore, levofloxacin as the preferred antibiotic in the perioperative period should be considered for replacement.…”

Section: Discussioncontrasting

confidence: 65%

“… 17–19 The major gram-negative bacterial isolate was Pseudomonas aeruginosa (3.42%), similar to a report from China. 20 However, Pseudomonas aeruginosa accounted for a high proportion of culture-positive isolates in Southern India, ranging from 13.1% to 25.9%, 21 , 22 which may be because Pseudomonas spp. prefer warm and moist environments.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies on endophthalmitis demonstrated that the susceptibilities of Gram-positive organisms to vancomycin were about 97.7–100%. 9 , 22 , 28 The high susceptibility rate of Gram-positive bacteria to vancomycin supports its continued use as empirical therapy. On the other hand, ceftazidime is often considered to be the first choice for the empirical treatment of gram-negative bacteria.…”

Section: Discussionmentioning

confidence: 99%

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Ten-Year Analysis of Pathogenic Factors and Etiological Characteristics of Endophthalmitis from a Tertiary Eye Center in North China

Liu¹,

Wan²,

Zhou³

et al. 2022

IDR

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Purpose To describe the etiology and spectrum of isolated pathogens in endophthalmitis over 10 years from an ophthalmic hospital in North China and report their antimicrobial susceptibilities. Patients and Methods The data covered the patients with endophthalmitis treated at Qingdao Eye Hospital from January 2011 to December 2020. Patients’ medical history, pathogenic factors, bacterial and fungal culture results of intraocular specimens, and in vitro drug sensitivity test results were assessed. Results A total of 524 cases were counted in this study. Exogenous endophthalmitis was the main component, accounting for 94.66%, of which 49.62% of eyes had a history of ophthalmic trauma, intraocular surgery in 26.72% and suppurative keratitis in 17.37%. By comparison, endogenous endophthalmitis was found in only 5.34% of eyes. Among the 292 strains of pathogenic organisms obtained by co-culture, gram-positive bacteria accounted for 64.04%, with Staphylococcus epidermidis as the predominant pathogen (29.45%). Gram-positive cocci were identified in 76.77% of eyes with traumatic endophthalmitis, while 53.70% of keratitis-associated endophthalmitis was caused by fungi. The high susceptibility of bacteria to vancomycin (77.78%~98.33%) supported its continued use as empirical treatment. Among the fluoroquinolones, gram-positive cocci showed a higher susceptibility to gatifloxacin (94.83%), while there was a significant decrease to levofloxacin (51.67%). Gram-negative bacteria were less sensitive to cephalosporins (45.95%~66.67%) than fluoroquinolones (68.42%~78.05%) and aminoglycosides (75.00%~78.05%). Fungal susceptibilities to voriconazole and amphotericin B were 90.16% and 70.31% respectively. More than half of the 11 antibiotics were observed to exhibit a trend of reduced susceptibility. Conclusion Ophthalmic trauma was the primary pathogenic factor of endophthalmitis. Gram-positive cocci were the most common pathogens of traumatic and postoperative endophthalmitis, while suppurative keratitis-associated endophthalmitis often resulted from fungal pathogens. Levofloxacin as the preferred antibiotic in the perioperative period and cephalosporin as the first-line drug for the treatment of empiric endophthalmitis need to be vigilant.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Ten-Year Analysis of Pathogenic Factors and Etiological Characteristics of Endophthalmitis from a Tertiary Eye Center in North China

Liu¹,

Wan²,

Zhou³

et al. 2022

IDR

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“…Initial treatments for intraocular foreign bodies include suturing and taking out the foreign bodies, in which preventing post-traumatic endophthalmitis by controlling bacterial growth is an essential process. In terms of the initial treatment for endophthalmitis, intravitreal injection (IVI) of antibiotics, such as vancomycin or ceftazidime, has been widely recommended in clinical practice (2). However, multidrug-resistant organisms resistant to both of these antibiotics have already been reported (3).…”

Section: Introductionmentioning

confidence: 99%

Vitrectomy using 0.025% povidone-iodine irrigation for treating post-traumatic endophthalmitis due to intraocular foreign bodies: Two case reports

Liu

et al. 2023

Front. Surg.

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Traumatic eye injury-related endophthalmitis is a serious traumatic complication that threatens the vision of many patients worldwide. Herein, we present two cases of traumatic endophthalmitis that underwent 0.025% povidone-iodine treatment and hoped to introduce the bactericidal effect of 0.025% povidone-iodine in balanced salt solution PLUS (0.025% PI-BSS PLUS) and its use in vitrectomy for traumatic endophthalmitis. The 0.025% PI-BSS PLUS solution is bactericidal and nontoxic when used as an irrigation solution in pars plana vitrectomy. The two cases of traumatic endophthalmitis were resolved by pars plana vitrectomy using 0.025% PI-BSS PLUS.

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Multidrug-resistant Cutibacterium avidum isolated from patients with acne vulgaris and other infections

Koizumi

Nakase

Hayashi

et al. 2022

Journal of Global Antimicrobial Resistance

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Endophthalmitis Isolates and Antibiotic Susceptibilities: A 10-Year Review of Culture-Proven Cases

Cited by 3 publications

References 4 publications

Ten-Year Analysis of Pathogenic Factors and Etiological Characteristics of Endophthalmitis from a Tertiary Eye Center in North China

Ten-Year Analysis of Pathogenic Factors and Etiological Characteristics of Endophthalmitis from a Tertiary Eye Center in North China

Vitrectomy using 0.025% povidone-iodine irrigation for treating post-traumatic endophthalmitis due to intraocular foreign bodies: Two case reports

Multidrug-resistant Cutibacterium avidum isolated from patients with acne vulgaris and other infections

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