Multidrug-resistant Cutibacterium avidum isolated from patients with acne vulgaris and other infections

Koizumi, Juri; Nakase, Keisuke; Hayashi, Nobuyuki; Nasu, Yutaka; Hirai, Yuji; Nakaminami, Hidemasa

doi:10.1016/j.jgar.2021.12.021

Cited by 12 publications

(10 citation statements)

References 34 publications

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“…Genomic DNA was extracted as previously described ( 10 ). Whole-genome sequencing was performed at the Bioengineering Lab.…”

Section: Methodsmentioning

confidence: 99%

“…Antimicrobial-resistant C. avidum and C. granulosum strains are more frequently found in patients with acne vulgaris than C. acnes ( 10 ). Furthermore, antimicrobial-resistant Staphylococcus epidermidis , a major skin commensal bacterium, was isolated more frequently from patients with acne vulgaris than from healthy individuals ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

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Multidrug Resistance Plasmid pTZC1 Could Be Pooled among Cutibacterium Strains on the Skin Surface

et al. 2023

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The emergence of antimicrobial resistance not only in Cutibacterium acnes strain but also other skin bacteria such as Staphylococcus epidermidis is a big concern due to antimicrobial use for the treatment of acne vulgaris. Increased prevalence of macrolides-clindamycin resistant C. acnes relates to the acquisition of exogenous antimicrobial resistance genes. erm (50) is harbored by the multidrug resistance plasmid pTZC1, which has been found in C. acnes and C. granulosum strains isolated from patients with acne vulgaris.

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“…Genomic DNA was extracted as previously described ( 10 ). Whole-genome sequencing was performed at the Bioengineering Lab.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multidrug Resistance Plasmid pTZC1 Could Be Pooled among Cutibacterium Strains on the Skin Surface

et al. 2023

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“…The suspension was incubated at 37°C for 40 min. The reaction solution was processed in phenol-chloroform-isoamyl alcohol (25:24:1) ( 10 ). Whole-genome sequencing was performed using an RS II system (Pacific Biosciences [PacBio], CA).…”

Section: Announcementmentioning

confidence: 99%

Identification of a Transferable Linear Plasmid Carrying the Macrolide-Clindamycin Resistance Gene erm (X) in a Cutibacterium acnes Isolate from a Patient with Acne Vulgaris in Japan

Koizumi

Nakase

Nakaminami

2022

Microbiol Resour Announc

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Cutibacterium acnes , one of the common skin bacteria, is known to exacerbate acne vulgaris. Macrolide-clindamycin-resistant C. acnes strains have been reported worldwide. In this study, we found a transferable linear plasmid carrying the macrolide-clindamycin resistance gene erm (X) in a C. acnes strain isolated from a patient with acne vulgaris.

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“…Thus, these results are contradictory and may indicate that there is no predominant disease-specific phylotype [7]. No classification is currently available for other species of the genus Cutibacterium, likely due to the fact that the proportion of infections caused by C. granulosum (2.4-4.8%) and C. avidum (4.2-10.7%) among all Cutibacterium infections is low, and C. avidum is present in a minor proportion in skin microbiota (0.4%) compared to C. acnes [30][31][32]. Infections with C. namnetense and C. humerusii have rarely been reported.…”

Section: Introductionmentioning

confidence: 99%

Comparative Genomic Analysis of Cutibacterium spp. Isolates in Implant-Associated Infections

Erbežnik,

Celar Šturm,

Strašek Smrdel

et al. 2023

Microorganisms

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Bacteria of the genus Cutibacterium are Gram-positive commensals and opportunistic pathogens that represent a major challenge in the diagnosis and treatment of implant-associated infections (IAIs). This study provides insight into the distribution of different sequence types (STs) of C. acnes, and the presence of virulence factors (VFs) in 64 Cutibacterium spp. isolates from suspected or confirmed IAIs obtained during routine microbiological diagnostics. Fifty-three C. acnes, six C. avidum, four C. granulosum, and one C. namnetense isolate, collected from different anatomical sites, were included in our study. Using whole-genome sequencing and a single-locus sequencing typing scheme, we successfully characterized all C. acnes strains and revealed the substantial diversity of STs, with the discovery of six previously unidentified STs. Phylotype IA1, previously associated with both healthy skin microbiome and infections, was the most prevalent, with ST A1 being the most common. Some minor differences in STs’ distribution were observed in correlation with anatomical location and association with infection. A genomic analysis of 40 investigated VFs among 64 selected strains showed no significant differences between different STs, anatomical sites, or infection-related and infection undetermined/unlikely groups of strains. Most differences in VF distribution were found between strains of different Cutibacterium spp., subspecies, and phylotypes, with CAMP factors, biofilm-related VFs, lipases, and heat shock proteins identified in all analyzed Cutibacterium spp.

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Multidrug-resistant Cutibacterium avidum isolated from patients with acne vulgaris and other infections

Cited by 12 publications

References 34 publications

Multidrug Resistance Plasmid pTZC1 Could Be Pooled among Cutibacterium Strains on the Skin Surface

Multidrug Resistance Plasmid pTZC1 Could Be Pooled among Cutibacterium Strains on the Skin Surface

Identification of a Transferable Linear Plasmid Carrying the Macrolide-Clindamycin Resistance Gene erm (X) in a Cutibacterium acnes Isolate from a Patient with Acne Vulgaris in Japan

Comparative Genomic Analysis of Cutibacterium spp. Isolates in Implant-Associated Infections

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