Endometrial Secretion and Early Mammalian Development

Beier, Henning M.; Petry, G.; Kühnel, Wolfgang

doi:10.1007/978-3-642-64993-6_14

Cited by 24 publications

(10 citation statements)

References 7 publications

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“…Plate 2, Fig. 6 demonstrates this protein to bea specifically staining band in the transferrin region (Beier, Kühnel & Petry, 1972 (Beier, 1970a;Beier et al, 1970). Oestradiol, given between the day of mating and Day 3 p.c.…”

Section: Oviducal and Uterine Compartmentsmentioning

confidence: 98%

“…Regulation of protease activity within the rabbit uterus is controlled by uterine protease inhibitors, the activity of which is clearly stimulated by ovarian hormones (Beier, 1970b;Denker, 1972). Lutwak-Mann (1955) (Beier, Petry & Kühnel, 1970;Denker, 1971). This membranebound enzyme is secreted by detachment of the apical protrusions, described above, into the luminal fluid.…”

Section: Oviducal and Uterine Compartmentsmentioning

confidence: 99%

“…Oestradiol, given between the day of mating and Day 3 p.c. in a single injection of 50 to 250 µg, gives rise to high concen¬ trations of serum-identical proteins, and suppression of uterine-specific proteins (Beier et al, 1970;Dies, 1972 (Beier et al, 1970Urzua et al, 1970;Arthur et al, 1972 (Beier, Mootz & Kühnel, 1972;Beier, 1973). Summarizing the data of our transfer experiments, as compiled in Table 1, we must emphasize that these extensions of transfer asynchrony at 4 days are remarkable, because of the much shorter maximal asynchronous interval of 48 hr reported earlier (Chang, 1950;Adams, 1967Adams, , 1970.…”

Section: Oviducal and Uterine Compartmentsmentioning

confidence: 99%

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Oviducal and Uterine Fluids

Beier¹

1974

Reproduction

173

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Section: Oviducal and Uterine Compartmentsmentioning

confidence: 98%

Section: Oviducal and Uterine Compartmentsmentioning

confidence: 99%

Section: Oviducal and Uterine Compartmentsmentioning

confidence: 99%

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Oviducal and Uterine Fluids

Beier¹

1974

Reproduction

173

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“…We observed that in the mouse there are extremely high levels of mdr gene expression during pregnancy in the secretory glandular epithelium of the endometrium of the uterus, a tissue engaged in high levels of secretory activity (20) hybridization under siliconized coverslips at 450C for 12 hr in air-tight moist chambers (22).…”

mentioning

confidence: 96%

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

Arceci

Croop

Horwitz

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

230

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A survey of the expression of the multidrugresistance gene (mdr) in mouse tissues revealed that a mdr mRNA species is expressed at extremely high levels in the gravid uterus. mdr mRNA expression levels increase dramatically during pregnancy compared to the relatively low levels of expression observed in the nongravid uterus. In situ hybridization experiments revealed that the increased expression of the mdr mRNA is specifically localized to the secretory epithelial cells of the endometrium. Immunocytochemistry studies with a mdr glycoprotein-specific antiserum demonstrate that the mdr glycoprotein is predominantly localized to the luminal surface of the secretory epithelial cells. These results indicate that the mdr gene expression in the uterus is controlled by the physiologic changes associated with pregnancy. Our data are consistent with a potential role for the mdr glycoprotein in the transport of substrate across the secretory epithelium of the gravid uterus.Resistance of malignant neoplasms to multiple chemotherapeutic agents is a major cause of treatment failure. Tumors initially sensitive to cytotoxic agents often recur and are refractory to multiple chemotherapeutic drugs (1). It has been inherently difficult to study such drug resistance in vivo. However, a number of highly resistant cell lines have been isolated in vitro by stepwise selection with single chemotherapeutic agents. These cell lines are often also resistant to multiple other structurally and functionally unrelated cytotoxic agents (2-6). Characteristic of such highly resistant cell lines is the amplification of a small group of closely related genes, termed mdr for multiple drug resistance (7-10).We and others have previously isolated from murine, hamster, and human cell lines cDNA clones complementary to members of the mdr gene family (7-14). The mdr phenotype can be conveyed by the transfection of murine (10)

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“…We were able to advance this secretion with 20 and 50 IU chorion gonadotropins. The premature secretion of ^-glycoprotein can also be observed during a normal pregnancy with exogenous progesterone ele vation [7,8]. As Kirchner [personal information] demonstrated with HCG injections between 2 days 12 h and 4 days 12 h, /9-glycoprotein can also be prematurely secreted under the influence of exogenous gonadotropin during the pre-implantation phase.…”

Section: Histological and Biochemical Transformation O F The Pseudoprmentioning

confidence: 81%

Pseudopregnancy in the Rabbit after Stimulation by Human Chorionic Gonadotropin

Beier

Kühnel²

1973

Horm Res

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The development of HCG-stimulated pseudopregnancy in the rabbit was studied with histological, electronmicroscopic and biochemical methods. This included the fate of the secretion unfertilized ova on the one hand and an analysis of the pseudopregnant endometrial secretion on the other. The unfertilized ova degenerate during pseudopregnancy, over half of these ova can be found in the uterus between the 4th and the 11th day after injection of HCG, the others are probably aborted. Endometrial secretion appears much sooner during the HCG-induced pseudopregnancy than in a normal pregnancy. The picture of maximal secretory capacity is maintained in the pseudopregnant cavum epithelium at least as long as in a normal pre-implantation pregnancy, i.e. up to the 7th day post coitum. The 11-day endometrium is no longer secretory active.During the secretory peak the pseudopregnant cavum epithelium exhibits a great number of apical protrusions, just as in normal pregnancy. With the electron microscope it was possible to demonstrate these protrusions as cell compartments rich in cytoplasm. The development of the pseudopregnant endometrial protein secretion is not identical with the normal one.The present results of differences between normal pregnancy and pseudopregnancy after stimulation with chorion gonadotropin provide further indications that the still unimplanted rabbit blastocyst must connect itself to the maternal regulating circuits before implantation. This is to adapt the intra-uterine environment to the growth and developmental requirements of the embryo and in order to synchronize the former with the embryonic system. The reactions of the external developmental factors do not proceed fully autonomously, but must to some extent be triggered off by the embryo itself.

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Endometrial Secretion and Early Mammalian Development

Cited by 24 publications

References 7 publications

Oviducal and Uterine Fluids

Oviducal and Uterine Fluids

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

Pseudopregnancy in the Rabbit after Stimulation by Human Chorionic Gonadotropin

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