Endometrial Aspiration Cytology for Diagnosis of Peritoneal Lesions in Extrauterine Malignancies

Saji, Haruya; Kurose, Keisuke; Sugiura, Ken Ichi; Miyagi, Etsuko; Onose, Ryo; Kato, Hiroyuki; Nakayama, Hiroki

doi:10.1159/000325790

Cited by 6 publications

(15 citation statements)

References 11 publications

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“…Papanicolaou and Marchetli described the 'sample aspiration method' in the diagnosis of cancer and other conditions of the uterus, which involved the use of a metal cannula which was developed by Cary in 1943. [1] Recently, aspiration has been found to be successful for even diagnosing extrauterine malignancies [2] as well as low-grade endometrial sarcomas. [3] Subsequent modifications of the endometrial aspiration technique included the endometrial brush, membrane filtration method, endometrial jet machine, Gravlee jet washers, Isaacs endometrial sampler, [4] Helix lippas loop method, endometrial brush, endocyte, End-pap sampler, and the disposable plastic cannula.…”

Section: Introductionmentioning

confidence: 99%

Cytological assessment of endometrial washings obtained with an insemination cannula and its histological correlation

Malik

Agarwal

Tandon

2008

J Cytol

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Background: Endometrial cytopathology is a powerful tool for the detection of a wide variety of benign atypias, infl ammatory changes, and infectious organisms. It is also helpful for the cytohormonal evaluation of patients and the detection of endometrial malignancies. Aims:The present study was carried out to assess the sensitivity and specifi city of endometrial cytology performed by using an insemination cannula. Materials and Methods:Endometrial aspiration using an insemination cannula was done in 60 cases who presented with dysuterine bleed, infertility, or postmenopausal bleed. The cytological evaluation of endometrial smears was correlated with histopathological fi ndings with reference to cyclic endometrium, atypical hyperplasia, and endometrial malignancies.Results: There were 35 patients in the reproductive and 25 in the menopausal age groups. The sample was inadequate in four cases but there was an overall 100% correlation between cytological and histological fi ndings of cyclic endometrium, atypical hyperplasia, and endometrial malignancy. The sensitivity and specifi city of endometrial aspiration was 83.3 and 95.4% respectively, with two false negative and false positive cases.Conclusions: Endometrial aspiration cytology was found to be a safe outpatient procedure in the diagnosis of normal and abnormal endometrium for patients of all ages.The present study emphasizes the need for endometrial screening in postmenopausal patients to enable the detection of endometrial malignancies at an early stage.

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Section: Introductionmentioning

confidence: 99%

Cytological assessment of endometrial washings obtained with an insemination cannula and its histological correlation

Malik

Agarwal

Tandon

2008

J Cytol

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“…Endometrial cytology was positive in approximately 40% of the patients in our series, whereas the positive rate of endometrial cytology is only 23% to 26% in EOC patients. 28,29 We speculate that intraperitoneal PPC cells reached the uterine cavity transtubally. 23,28 The most important findings of the present study were related to prognostic factors for clinical PPC.…”

Section: Discussionmentioning

confidence: 93%

“…28,29 We speculate that intraperitoneal PPC cells reached the uterine cavity transtubally. 23,28 The most important findings of the present study were related to prognostic factors for clinical PPC. Multivariate analysis showed that both NAC and the residual tumor diameter had an influence on PFS, whereas OS was only influenced by the residual tumor diameter.…”

Section: Discussionmentioning

confidence: 93%

Multicenter Clinicopathological Study of High-Grade Serous Carcinoma Presenting as Primary Peritoneal Carcinoma

Komiyama

Nishijima

Kondo

et al. 2018

Int J Gynecol Cancer

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“…Several researchers reported occasional ICCs in uterine cytology from patients with tubo‐ovarian cancer, and these studies also showed an 11.7%‐50% of positive rate of ICCs in endometrial cytology (Table ) . However, most of these previous studies included various histological subtypes such as clear cell carcinoma or mucinous carcinoma, and most of the patients were at FIGO stage I.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the comparison with our results should be limited to cases with HGSC. Accordingly, 14%‐50% of HGSC cases were reported to be positive for ICCs in endometrial cytology . Interestingly, the positive rate of ICCs seemed to differ according to the sampling methods, with the rate higher in aspiration than in brush (14%‐25% vs 30.6%‐50%).…”

Section: Discussionmentioning

confidence: 99%

Characteristics and prognostic significance of incidentally detected cancer cells in uterine specimens of patients with pelvic high‐grade serous carcinoma

et al. 2020

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Objective Cases of pelvic high‐grade serous carcinoma (HGSC) with incidentally detected cancer cells (ICCs) in endometrial and/or cervicovaginal cytology have been reported. This study aimed to clarify the incidence and characteristics of pelvic HGSC with ICCs and to determine whether ICCs have a negative prognostic impact. Methods Patients with ovarian/tubal/peritoneal HGSC who underwent pre‐treatment uterine (endometrial/cervicovaginal) cytology or biopsy between January 2007 and May 2017 were included. We reviewed the frequencies of ICCs and compared the clinicopathological features and survival outcome between the ICC‐positive and ICC‐negative groups. Results Of the 160 patients evaluated, 69 (43.2%) had positive ICCs in at least one uterine specimen. There were no significant differences in clinicopathological characteristics, such as age, FIGO stage, serum CA125 level, ascites, and tubal lesion, between the two groups. Moreover, ICCs had no significant survival impact on progression‐free survival or overall survival. Conclusion Our study showed a high rate of pelvic HGSC with ICCs in pre‐treatment uterine specimens. The ICCs per se had no negative impact on survival outcomes of pelvic HGSC. Furthermore, uterine biopsy and cytology can be useful and less‐invasive methods to obtain tubo‐ovarian/peritoneal cancer cells before treatment.

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Endometrial Aspiration Cytology for Diagnosis of Peritoneal Lesions in Extrauterine Malignancies

Cited by 6 publications

References 11 publications

Cytological assessment of endometrial washings obtained with an insemination cannula and its histological correlation

Cytological assessment of endometrial washings obtained with an insemination cannula and its histological correlation

Multicenter Clinicopathological Study of High-Grade Serous Carcinoma Presenting as Primary Peritoneal Carcinoma

Characteristics and prognostic significance of incidentally detected cancer cells in uterine specimens of patients with pelvic high‐grade serous carcinoma

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