Endogenous and Exogenous Hydrogen Sulfide Promotes Resolution of Colitis in Rats

Wallace, John L.; Vong, Linda; McKnight, Webb; Dicay, Michael; Martin, Gary R.

doi:10.1053/j.gastro.2009.04.012

Cited by 273 publications

(325 citation statements)

References 49 publications

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“…Although sulfate/sulfite-reducing bacteria are positively associated with inflammation (10, 11), both pro-and anti-inflammatory signaling have been attributed to H 2 S (12)(13)(14).…”

mentioning

confidence: 99%

Metabolic niche of a prominent sulfate-reducing human gut bacterium

Rey¹,

Gonzalez²,

Cheng³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

335

277

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Sulfate-reducing bacteria (SRB) colonize the guts of ∼50% of humans. We used genome-wide transposon mutagenesis and insertion-site sequencing, RNA-Seq, plus mass spectrometry to characterize genetic and environmental factors that impact the niche of Desulfovibrio piger, the most common SRB in a surveyed cohort of healthy US adults. Gnotobiotic mice were colonized with an assemblage of sequenced human gut bacterial species with or without D. piger and fed diets with different levels and types of carbohydrates and sulfur sources. Diet was a major determinant of functions expressed by this artificial nine-member community and of the genes that impact D. piger fitness; the latter includes high-and low-affinity systems for using ammonia, a limiting resource for D. piger in mice consuming a polysaccharide-rich diet. Although genes involved in hydrogen consumption and sulfate reduction are necessary for its colonization, varying dietary-free sulfate levels did not significantly alter levels of D. piger, which can obtain sulfate from the host in part via cross-feeding mediated by Bacteroides-encoded sulfatases. Chondroitin sulfate, a common dietary supplement, increased D. piger and H 2 S levels without compromising gut barrier integrity. A chondroitin sulfate-supplemented diet together with D. piger impacted the assemblage's substrate utilization preferences, allowing consumption of more reduced carbon sources and increasing the abundance of the H 2 -producing Actinobacterium, Collinsella aerofaciens. Our findings provide genetic and metabolic details of how this H 2 -consuming SRB shapes the responses of a microbiota to diet ingredients and a framework for examining how individuals lacking D. piger differ from those who harbor it.artificial human gut microbiota/microbiome | determinants of microbial fitness | hydrogenotrophs | microbial foodwebs | hydrogen sulfide

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“…Although sulfate/sulfite-reducing bacteria are positively associated with inflammation (10, 11), both pro-and anti-inflammatory signaling have been attributed to H 2 S (12)(13)(14).…”

mentioning

confidence: 99%

Metabolic niche of a prominent sulfate-reducing human gut bacterium

Rey¹,

Gonzalez²,

Cheng³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

335

277

View full text Add to dashboard Cite

show abstract

“…On the other hand, exogenous H 2 S donors can increase the resistance of the mucosa to injury [5][6][7]. Moreover, H 2 S synthesis is markedly up-regulated after mucosal injury occurs, and it contributes significantly to promoting the healing of the injured tissue [8,9]. H 2 S donors can accelerate ulcer healing in experimental models [8,9].…”

mentioning

confidence: 99%

“…Moreover, H 2 S synthesis is markedly up-regulated after mucosal injury occurs, and it contributes significantly to promoting the healing of the injured tissue [8,9]. H 2 S donors can accelerate ulcer healing in experimental models [8,9]. There is emerging evidence that H 2 S plays an important role in promoting resolution of inflammation, in part by up-regulating cyclooxygenase-2 expression [9].…”

mentioning

confidence: 99%

“…H 2 S donors can accelerate ulcer healing in experimental models [8,9]. There is emerging evidence that H 2 S plays an important role in promoting resolution of inflammation, in part by up-regulating cyclooxygenase-2 expression [9].…”

mentioning

confidence: 99%

“…One cannot exclude the possibility that the reduced cytokine expression/production occurred, at least in part, as a consequence of the reduced gastric injury, though H 2 S has been shown to reduce pro-inflammatory cytokine expression/synthesis in other in vivo models, including colitis [9,11,12].…”

mentioning

confidence: 99%

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Hydrogen Sulfide: A Rescue Molecule for Mucosal Defence and Repair

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Eicosanoid Pathway Modulators: Prostaglandins, Prostacyclin, and Thromboxane

Mazaleuskaya

Ricciotti

2021

Burger's Medicinal Chemistry and Drug Discovery

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Prostanoids (prostaglandins, prostacyclin, and thromboxane) are bioactive lipids, members of the eicosanoid class of compounds, derived from arachidonic acid (AA). They are involved in controlling homeostatic and pathophysiological processes. Their biosynthesis is the result of the coordinated actions of several enzymes. Cyclooxygenases (COXs) catalyze the committed step in the conversion of AA into prostanoids. There are two COX isozymes: the constitutive COX‐1 and the inducible COX‐2, both of which have different patterns of expression and biological functions. COX‐1 and COX‐2 are the targets of traditional nonsteroidal anti‐inflammatory drugs (tNSAIDs), which are used to relieve pain, fever and inflammation. Despite their clinical efficacy, tNSAIDs cause side effects, particularly in the gastrointestinal (GI) tract. NSAIDs selective for COX‐2 inhibition (coxibs) were purposefully designed to spare GI side effects, but predisposed patients to increased cardiovascular (CV) risks. The GI and CV complications from existing NSAIDs prompted interest in the downstream effectors of the COX enzymes as novel drug targets. This article describes various safety issues with tNSAIDs and coxibs, and discusses the current development of novel classes of drugs targeting the AA pathway, including nitric oxide‐releasing and hydrogen sulfide‐releasing NSAIDs, inhibitors of prostanoid synthases, dual inhibitors, and prostanoid receptor agonists and antagonists.

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Endogenous and Exogenous Hydrogen Sulfide Promotes Resolution of Colitis in Rats

Cited by 273 publications

References 49 publications

Metabolic niche of a prominent sulfate-reducing human gut bacterium

Metabolic niche of a prominent sulfate-reducing human gut bacterium

Hydrogen Sulfide: A Rescue Molecule for Mucosal Defence and Repair

Eicosanoid Pathway Modulators: Prostaglandins, Prostacyclin, and Thromboxane

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