Hydrogen Sulfide: A Rescue Molecule for Mucosal Defence and Repair

Wallace, John L.

doi:10.1007/s10620-012-2119-2

Cited by 16 publications

(9 citation statements)

References 21 publications

(41 reference statements)

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“…In the rehabilitation group by contrast, H 2 S reaches a relatively high level (81.12±3.02 μM), suggesting that the homeostasis of ClO -/H 2 S in gastric mucosa can be mediated by the intake of stimulus. Together with the alleviated inflammatory manifestation observed in rehabilitation group, this result leads us to believe that oral H 2 S-releasing drug will probably exert both the protective and the curative effects against gastritis by not only consuming the ROS but also promoting angiogenesis, respectively 51 . Based on above findings, the shifting of ClO -/H 2 S equilibrium in gastric mucosa can be monitored by the developed probe, providing the result associated closely with the pathologic manifestation, as well as the damaging effect of ClO -and the therapeutic effect of H 2 S on the mucosa.…”

Section: Please Do Not Adjust Marginsmentioning

confidence: 77%

In situ quantification and evaluation of ClO⁻/H₂S homeostasis in inflammatory gastric tissue by applying a rationally designed dual-response fluorescence probe featuring a novel H⁺-activated mechanism

Chen

Liu

et al. 2017

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Homeostasis of ClO -/H2S plays crucial role in the damage and repair of gastric tissue, but has been rarely investigated due to the challenge of in situ analysis in the highly acidic gastric environment. Herein, we design a new H + -activated optical mechanism including the controllable photo-induced electron transfer (PET) and the switch of electron push-pull (SEPP) to develop the simple yet multifunctional probe (

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Section: Please Do Not Adjust Marginsmentioning

confidence: 77%

In situ quantification and evaluation of ClO⁻/H₂S homeostasis in inflammatory gastric tissue by applying a rationally designed dual-response fluorescence probe featuring a novel H⁺-activated mechanism

Chen

Liu

et al. 2017

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“…Moreover, recent reports have also revealed that H 2 S has a key role in the inflammatory process. Indeed, different studies have demonstrated that H 2 S is part of the pro‐resolutive system, stopping inflammation and promoting healing (Zanardo et al , ; Wallace, ). H 2 S has also been shown to counteract inflammation by triggering resolutive pathways through the engagement of annexin A1 (Brancaleone et al , ).…”

Section: Introductionmentioning

confidence: 99%

d‐Penicillamine modulates hydrogen sulfide (H₂S) pathway through selective inhibition of cystathionine‐γ‐lyase

Brancaleone

Esposito

Gargiulo

et al. 2016

British J Pharmacology

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BACKGROUND AND PURPOSEHydrogen sulfide (H 2 S) is a gasotransmitter produced from L-cysteine through the enzymatic action of cystathionine-γ-lyase (CSE) and/or cystathionine-β-synthase. D-Penicillamine is the D isomer of a dimethylated cysteine and has been used for the treatment of rheumatoid arthritis. As D-penicillamine is structurally very similar to cysteine, we have investigated whether D-penicillamine, as a cysteine analogue, has an effect on the H 2 S pathway. EXPERIMENTAL APPROACHWe tested the effect of D-penicillamine (0.01-1 mM) in mouse aortic rings mounted in isolated organ baths and determined whether it could affect H 2 S biosynthesis. In particular, we investigated any possible inhibitor or donor behaviour by using recombinant enzyme-based assays and an in vivo approach. KEY RESULTSD-Penicillamine, per se, showed little or no vasodilator effect, and it cannot be metabolized as a substrate in place of L-cysteine. However, D-penicillamine significantly reduced L-cysteine-induced vasodilatation in a concentration-dependent manner through inhibition of H 2 S biosynthesis, and this effect occurred at concentrations 10 times lower than those needed to induce the release of H 2 S. In particular, D-penicillamine selectively inhibited CSE in a pyridoxal-5′-phospate-dependent manner. CONCLUSIONS AND IMPLICATIONSTaken together, our results suggest that D-penicillamine acts as a selective CSE inhibitor, leading to new perspectives in the design and use of specific pharmacological tools for H 2 S research. In addition, the inhibitory effect of D-penicillamine on CSE could account for its beneficial action in rheumatoid arthritis patients, where H 2 S has been shown to have a detrimental effect. AbbreviationsMPST, 3-mercaptopyruvate sulfurtransferase; CBS, cystathionine-β-synthase; CSE, cystathionine-γ-lyase; DPD, N,N-dimethylp-phenylenediamine sulfate; D-pen, D-penicillamine; L-pen, L-penicillamine; H 2 S, hydrogen sulfide; IVM, intravital microscopy; PAG, D,L-propargylglycine; PE, phenylephrine; PLP, pyridoxal-5′-phosphate; RA, rheumatoid arthritis; TCA, trichloroacetic acid; ZnAc, zinc acetate BJP IntroductionHydrogen sulfide (H 2 S) is a gaseous molecule endogenously synthesized by cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MPST). These enzymes are differently distributed throughout the human body and within cell compartments. MPST is mainly expressed in mitochondria (Stipanuk, 2004;Shibuya et al., 2009), while CSE and CBS show a wide distribution in diverse cell types. CSE and CBS can both metabolize the substrate L-cysteine to release H 2 S, and this reaction is strictly dependent upon the enzyme cofactor pyridoxal-5′-phosphate (PLP). The role of H 2 S has been widely investigated in several organs and tissues, and many studies have confirmed its crucial role in body physiology. For instance, CSE represents the prominent enzyme within the cardiovascular system, where H 2 S is a major player involved in regulating the function of heart and bloo...

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“…The gastroprotective effect of H 2 S involves several mechanisms, such as maintenance of gastric mucosal blood flow, stimulation of bicarbonate secretion, inhibition of pro-inflammatory cytokine expression/release stimulation of prostaglandin synthesis, reduced leukocyteendothelial adherence, decreased reactive oxygen metabolite production and enhanced tissue repair [35].…”

Section: Hydrogen Sulfidmentioning

confidence: 99%

The Role of Capsaicin-Sensitive Afferent Nerves in Gastric Mucosal Protection Initiated Centrally or Peripherally under Experimental Conditions

Gyires¹

2014

Capsaicin - Sensitive Neural Afferentation and the Gastrointestinal Tract: From Bench to Bedside

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Hydrogen Sulfide: A Rescue Molecule for Mucosal Defence and Repair

Cited by 16 publications

References 21 publications

In situ quantification and evaluation of ClO⁻/H₂S homeostasis in inflammatory gastric tissue by applying a rationally designed dual-response fluorescence probe featuring a novel H⁺-activated mechanism

In situ quantification and evaluation of ClO⁻/H₂S homeostasis in inflammatory gastric tissue by applying a rationally designed dual-response fluorescence probe featuring a novel H⁺-activated mechanism

d‐Penicillamine modulates hydrogen sulfide (H₂S) pathway through selective inhibition of cystathionine‐γ‐lyase

The Role of Capsaicin-Sensitive Afferent Nerves in Gastric Mucosal Protection Initiated Centrally or Peripherally under Experimental Conditions

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Hydrogen Sulfide: A Rescue Molecule for Mucosal Defence and Repair

Cited by 16 publications

References 21 publications

In situ quantification and evaluation of ClO−/H2S homeostasis in inflammatory gastric tissue by applying a rationally designed dual-response fluorescence probe featuring a novel H+-activated mechanism

In situ quantification and evaluation of ClO−/H2S homeostasis in inflammatory gastric tissue by applying a rationally designed dual-response fluorescence probe featuring a novel H+-activated mechanism

d‐Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine‐γ‐lyase

The Role of Capsaicin-Sensitive Afferent Nerves in Gastric Mucosal Protection Initiated Centrally or Peripherally under Experimental Conditions

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In situ quantification and evaluation of ClO⁻/H₂S homeostasis in inflammatory gastric tissue by applying a rationally designed dual-response fluorescence probe featuring a novel H⁺-activated mechanism

In situ quantification and evaluation of ClO⁻/H₂S homeostasis in inflammatory gastric tissue by applying a rationally designed dual-response fluorescence probe featuring a novel H⁺-activated mechanism

d‐Penicillamine modulates hydrogen sulfide (H₂S) pathway through selective inhibition of cystathionine‐γ‐lyase