Endocrine effects of chlorinated hydrocarbons in rhesus monkeys

Müller, Wolfgang; Hobson, W.; Fuller, Gene B.; Knauf, Wolfgang; Coulston, F.; Körte, F.

doi:10.1016/0147-6513(78)90007-6

Cited by 60 publications

(22 citation statements)

References 9 publications

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“…This conclusion is supported by the demonstration of altered steroidogenesis in the rhesus monkey in the absence of changes in circulating levels of pituitary gonadotropins (36). Altered ovarian steroidogenesis has also been shown in both the cynomolgus monkey (37) and the rat (38).…”

Section: Introductionsupporting

confidence: 65%

“…In adult animals (mice, rats, and monkeys) treated with PCBs (Clophen A-60 or Aroclor 1254), there is evidence of increased estrous/menstrual cycle lengths (36,67,68) and evidence of anovulation in the monkeys (36). Effects of PCBs on the estrous cycle, however, have not been found in another study in rats treated with Aroclor 1242 (3.7 or 7.5 mg/kg/day for 36 weeks).…”

Section: Introductionmentioning

confidence: 79%

“…Effects of PCBs on the estrous cycle, however, have not been found in another study in rats treated with Aroclor 1242 (3.7 or 7.5 mg/kg/day for 36 weeks). Changes in circulating levels of ovarian steroids have been documented (36,55) at PCB treatment levels as low as 7.5 mg/kg/day for 36 weeks. Reduction of the number of fertilized ova that implant has also been reported (67).…”

Section: Introductionmentioning

confidence: 99%

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The reproductive toxicology of Great Lakes contaminants.

Foster

1995

Environ Health Perspect

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The Great Lakes basin is characterized as a heavily populated and industrialized region in which a large number of environmental contaminants have been identified. Both the scientific community and the public have voiced concern that contaminants present in the Great Lakes may pose undue risk to human reproduction. Evidence from animal experiments, wildlife studies, and reports of occupational and accidental human exposures indicate that chemical contaminants can adversely affect reproduction. The purpose of this paper is to review the reproductive toxicity of some of the many contaminants known to be present in the Great Lakes. Since the number of chemicals present in the Great Lakes is far too great for each to be adequately reviewed here, discussion will be limited to those contaminants that have been identified in human serum, ovarian follicular fluid, and semen obtained from people residing in the Great Lakes region. It is concluded that a) the data at present is too limited to support the notion that reproduction, in the general population, has been impaired by exposure to chemicals present in the Great Lakes; b) the lack of data in some cases such as for hexachloroethane and 1,2,4-trichlobenzene does provide reason for concern and underscores the need for further research in this area; and c) the potential for a number of the compounds, including polychlorinated biphenyls (PCBs) and 1,1,1-trichloro-2,2-bis(pchlorophenyl) ethane (DDT), to disrupt endocrine functions suggests that additive or synergistic effects of these compounds may already be causing adverse effects on reproduction in sensitive individuals, which needs to be explored. -Environ Health Perspect 1 03(Suppl 9): 63-69 (1995)

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Section: Introductionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

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The reproductive toxicology of Great Lakes contaminants.

Foster

1995

Environ Health Perspect

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“…For example, in rats exposed to the commercial mixture Aroclor-1242, a reduction in the number of follicles was observed [42]. In rhesus monkeys, administration of PCBs altered menstrual cycle, induced amenorrhea [41] and inhibited ovulation in 50% of treated animals [43]. To date, data on the direct effects of these compounds on oocytes are still scarce.…”

Section: Introductionmentioning

confidence: 99%

Impact of endocrine disrupters on ovarian function and embryonic development

Gandolfi

Pocar²,

Brevini

et al. 2002

Domestic Animal Endocrinology

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“…Lindane, also cause a decrease in circulating estradiol levels in rats (Eldridge et al, 1994;Gojmerac et al, 1996). In monkeys, ovulatory levels of estradiol were reduced after high doses of hexachlorobenzene (Foster et al, 1995), which also induced anovulatory cycles and suppression of circulating levels of estradiol (Muller et al, 1978), and a dose dependent suppression of serum progesterone concentrations during the luteal phase (Foster et al, 1992). Progesterone levels may be decreased by exposure to methoxychlor as well, especially during the estrus phase of the estrus cycle in rats (Chapin et al, 1997;Cumming and Lasley, 1993).…”

Section: Effects Of Organophosphate Insecticides On Endocrine Systemmentioning

confidence: 99%