Endocrine autoimmunity in families with type 1 diabetes: frequent appearance of thyroid autoimmunity during late childhood and adolescence

Bonifacio, Ezio; Mayr, A.; Knopff, Annette; Ziegler, Anette‐Gabriele

doi:10.1007/s00125-008-1206-6

Cited by 20 publications

(33 citation statements)

References 36 publications

(47 reference statements)

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“…Although this study had a modest sample size, other small studies have identified similar results (2,3,9,19,(21)(22)(23)(24), including one in another sample of the Brazilian population (12). According to these authors, thyroid autoantibodies occur in 8% to 25% of FDR of T1DM patients.…”

Section: Discussionsupporting

confidence: 61%

“…P atients with type 1 diabetes mellitus (T1DM) are at increased risk for other autoimmune disorders, such as autoimmune thyroid disease (ATD), celiac disease and Addison's disease (1)(2)(3). The most prevalent autoimmune disease in patients with T1DM is ATD.…”

Section: Introductionmentioning

confidence: 99%

“…Although quite a variable frequency of thyroid antibodies (thyroglobulin antibody -TgAb and thyroid peroxidase antibody -TPOAb) and thyroid dysfunction (TD) has been reported in patients with T1DM among different populations (from 3 to 50%), a high prevalence of ATD has been reported in most cases. This suggests that both diseases share etiopathogenic mechanisms (2)(3)(4)(5)(6). Current guidelines recommend that all patients with T1DM should undergo an annual screening for thyroid disease with at least a serum TSH measurement (2,(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

“…This suggests that both diseases share etiopathogenic mechanisms (2)(3)(4)(5)(6). Current guidelines recommend that all patients with T1DM should undergo an annual screening for thyroid disease with at least a serum TSH measurement (2,(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have shown that first degree relatives (FDR) of patients with T1DM have an increased prevalence of thyroid abnormalities than the general population (2,3,9-12), ranging from 8 to 25% (2,3). However, these studies have included mostly Caucasians, very little is known about the prevalence of ATD in other ethnic groups and thyroid disease often remains undiagnosed in this group (12,13).…”

Section: Introductionmentioning

confidence: 99%

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Thyroid disorders are common in first-degree relatives of individuals with type 1 diabetes mellitus

Araújo

Barone

Melleti

et al. 2015

Arch. Endocrinol. Metab.

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Objective: Thyroid diseases are common in individuals with type 1 diabetes mellitus (T1DM) and should be investigated annually in these individuals. The aim of this study was to evaluate the frequency of thyroid diseases in first degree relatives (FDR) of patients with T1DM. Subjects and me thods: Eighty individuals (40 patients with T1DM and 40 FDR) were interviewed and blood was sampled for thyroid-stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase (TPO) antibodies measurement. Autoantibodies against glutamic acid decarboxylase 65 (GAD65), islet antigen-2 (IA2) and autoantibodies against insulin (AAI) were measured in FDR. Results: We found a similar prevalence of thyroid dysfunction in patients with T1DM and their FDR (22.5% vs. 27.5%; p = 0,79). There were no differences in serum TSH levels (p = 0.29), FT4 (p = 0,45), frequency of abnormal TSH (p = 0.28), positive TPO antibodies (p = 0.13), titers of TPO antibodies (in positive cases) between patients with T1DM and their FDR (p = 0.94). Conclusions: Thyroid abnormalities seem to be common not only in patients with T1DM but also in their FDR, which suggests that screening strategies for thyroid diseases might also be useful to these individuals. Arch Endocrinol Metab. 2015;59(2):112-5

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Thyroid disorders are common in first-degree relatives of individuals with type 1 diabetes mellitus

Araújo

Barone

Melleti

et al. 2015

Arch. Endocrinol. Metab.

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Current literature in diabetes

2009

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

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Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes

Ziegler

Bonifacio²

2012

Diabetologia

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227

176

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Aims/hypothesis Seroconversion to islet autoantibodies precedes type 1 diabetes. This study aimed to identify periods of high seroconversion incidence, which could be targeted for mechanistic and therapeutic studies. Methods Incidence of islet autoantibodies was calculated in 1,650 genetically at-risk children followed with measurements of islet autoantibodies and thyroid autoantibodies at age 9 months and 2, 5, 8, 11, 14 and 17 years. Peak incidence periods were confirmed in a second cohort of 150 children followed until age 6 years with three-monthly samples up to age 3 years. Results Islet autoantibody incidence (per 1,000 person-years) was 18.5 until age 9 months, 21 from 9 months to 2 years and <10 for intervals after age 2 years. The second cohort confirmed peak incidence around age 9 months and demonstrated an absence of seroconversion before this age. Seroconversion to insulin autoantibodies occurred earlier than other autoantibodies (p<0.01 against glutamic acid decarboxylase [GAD]-, insulinoma-associated protein 2 [IA-2]-and zinc transporter 8 [ZnT8]-autoantibodies). Early peak seroconversion incidence was most evident in children with highrisk HLA DR3/4-DQ8 or DR4/4-DQ8 genotypes. Conclusion The age period 9 months to 2 years is associated with a high incidence of activation of type 1 diabetesassociated autoimmunity in genetically at-risk children and should be targeted for effective primary prevention strategies.

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Endocrine autoimmunity in families with type 1 diabetes: frequent appearance of thyroid autoimmunity during late childhood and adolescence

Abstract: Among children of patients with type 1 diabetes, the appearance of thyroid autoantibodies is frequent, is not synchronous to the appearance of other autoantibodies and is most common in late childhood and adolescence.

Cited by 20 publications

References 36 publications

Thyroid disorders are common in first-degree relatives of individuals with type 1 diabetes mellitus

Thyroid disorders are common in first-degree relatives of individuals with type 1 diabetes mellitus

Current literature in diabetes

Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes

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