Endocrine associations with health-related quality of life in coronary artery disease patients

Fatigue in Patients With Coronary Artery Disease

“…On the other hand, the HADS has reliable psychometric properties and is widely used as a screening instrument in patients with cardiac disease (3,5). In addition, our group has recently reported that decreased thyroid hormone concentrations independently predicted worse health related quality of life in patients with CAD, thus supporting our present results (42).…”

Relationship of health-related quality of life with fatigue and exercise capacity in patients with coronary artery disease

“…30 We have recently showed in CAD patients that lower thyroid hormone and cortisol concentrations were associated with greater fatigue 31 and with worse HRQoL. 32 In this context, identification of biologic phenotypes of fatigue could improve stratification of fatigued CAD patients. Furthermore, identification of mechanisms underlying fatigue could potentially improve management leading to better patient-centered outcomes of CAD patients.…”

Exploring potential biomarkers associated with health-related quality of life in patients with coronary artery disease and heart failure

“…Findings from other studies demonstrated that in CAD patients without documented thyroid disorders, lower thyroid hormone concentrations were associated with greater fatigue symptom severity and with worse HRQoL across role limitations due to physical and emotional problems and mental health domains as measured by the 36-item Short Form Medical Outcome Questionnaire (SF-36). 14,27,28 A study of primary brain tumour patients demonstrated that decreased serum fT3 and TSH concentrations were associated with worse HRQoL independently from brain tumour histological diagnosis and patients’ age, gender and functional status. 16 In addition, during rehabilitation of stable CAD patients after ACS, lower fT3 concentrations were associated with worse cognitive outcomes.…”