Fatigue in Patients With Coronary Artery Disease

Bunevičius, Adomas; Gintauskienė, Viltė Marija; Podlipskytė, Aurelija; Žaliūnas, Remigijus; Brožaitienė, Julija; Prange, Arthur J.; Bunevičius, Robertas

doi:10.1097/psy.0b013e318268e7f0

Cited by 19 publications

(4 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of our quantile regression analysis support this in that cortisol was found to be a significant predictor only in the cognitive/mood dimension of fatigue. A study of the relationship between fatigue and cortisol in patients with coronary artery disease reported results similar to those in our study in that patients had lower cortisol levels as mental fatigue levels increased, unlike physical fatigue 18 . Therefore, it seems that the relationship between cortisol and fatigue might differ depending on the levels of fatigue in patients with HBV.…”

Section: Discussionsupporting

confidence: 86%

A quantile regression approach to explain the relationship of Fatigue and Cortisol, Cytokine among Koreans with Hepatitis B

Jang

Kim

Lee

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Fatigue is a major symptom among patients with Hepatitis B virus (HBV). However, the physiological mechanisms regarding mediate fatigue and the relationships between fatigue, cortisol and cytokines are unclear in patients with HBV. The purpose of this study was to examine the relationships between perceived fatigue, cortisol, and cytokines in Korean patients with HBV. The mean score for overall fatigue was moderate. In linear regression analyses, TNF-α was only significant as a predictor of fatigue. In quantile regression analyses, the cortisol level was significant in the 70th, 80th, 90th quantiles in the cognitive/mood fatigue subdimension, which correspond to severe levels of fatigue. IL-6 levels were significant in 90th quantile in overall fatigue and in the cognitive/mood fatigue subdimension. Cortisol, IL-6, and TNF- α were related to perceived fatigue in patients with HBV, particularly in the cognitive/mood dimension. This suggests that the fatigue patterns of patients with HBV are related to their mental and mood states and physical responses, such as cortisol and cytokine levels, are correlated with the nature of the fatigue. In the clinic, interventions to manage fatigue in patients with HBV should be developed based on the characteristics of the fatigue.

show abstract

Section: Discussionsupporting

confidence: 86%

A quantile regression approach to explain the relationship of Fatigue and Cortisol, Cytokine among Koreans with Hepatitis B

Jang

Kim

Lee

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Fatigue and vital exhaustion are associated with cortisol output, as well as being risk factors for the occurrence of adverse cardiac events over time ( 27 , 28 ). Associations between lower levels of waking cortisol and fatigue have been reported in older adults and coronary artery disease patients ( 29 , 30 ). It is possible that fatigue or exhaustion may be a factor influencing the association between lower waking cortisol and adverse outcomes in the current study.…”

Section: Discussionmentioning

confidence: 95%

Diurnal Cortisol Rhythm Is Associated With Adverse Cardiac Events and Mortality in Coronary Artery Bypass Patients

Ronaldson

Kidd

Poole

et al. 2015

The Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

Purpose:There is growing evidence that the hypothalamic-pituitary-adrenal axis plays a role in the progression of cardiovascular disease. We examined the relationship between diurnal cortisol rhythm and adverse events in patients undergoing coronary artery bypass graft (CABG) surgery. We hypothesized that a flatter presurgical diurnal cortisol slope would be associated with higher rates of adverse cardiac events and death in the years following the CABG procedure.Methods:Repeated measures of saliva were taken over the day from 250 CABG patients 1 month before surgery to assess diurnal cortisol slope and overall output (area under the curve). Long-term clinical outcomes were occurrence of a major adverse cardiac event (MACE) and death, and were collected up to 2.68 (SD = 0.40) years after surgery. Cox proportional hazard models were used to determine relationships between presurgical cortisol and clinical outcomes. EuroSCORE, chronic illness burden, and whether or not the patient had undergone cardiopulmonary bypass were included as covariates in the models.Results:Diurnal cortisol slope predicted the occurrence of MACE or death after surgery (hazard ratio = 0.73; 95% confidence interval = 0.56–0.96; P = .023). Patients with a steeper slope were at reduced risk of adverse outcomes. This association was driven by changes in both waking and evening cortisol levels.Conclusion:These results provide evidence for a link between diurnal cortisol rhythm and recovery after CABG. Measuring diurnal cortisol slope before surgery may help to identify those patients at risk of adverse outcomes in the years after the procedure.

show abstract

“…Thyroid hormones are known to play an essential role in many biological processes in every tissue and could represent a catabolic state which had weak muscle strength and a propensity to fatigue. Bunevicius et al documented that lower fT3 concentrations were associated with increased physical fatigue and exertion fatigue in patients with CAD [ 35 ]. In addition, thyroid hormones are essential in the nervous system development of the human brain [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Low fT3 is associated with diminished health-related quality of life in patients with acute coronary syndrome treated with drug-eluting stent: a longitudinal observational study

et al. 2017

View full text Add to dashboard Cite

Acute coronary syndrome (ACS) patients with low triiodothyronine (T3) syndrome characterized by low free T3 (fT3) levels with normal thyroxine (T4) and thyroid-stimulating hormone (TSH) have a higher rate of death. The impact of fT3 on Health related quality of life (HRQOL) in patients with ACS is still unknown. 528 ACS patients treated with drug-eluting stent (DES) were included in this prospective, observational study. Patients were classified into low fT3 group (n=126) and normal fT3 group (n=402) according to serum fT3 level. Every patient was prospectively interviewed at baseline and 1 year following percutaneous coronary intervention (PCI). HRQOL was assessed with the use of the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Low fT3 patients had poorer HRQOL than normal fT3 patients both at baseline and 1-year follow-up (all p<0.05). During 1-year follow-up, HRQOL scores for all patients were significantly higher than baseline. Low fT3 patients had lesser gains in physical functioning, bodily pain, general health, vitality, social functioning and role emotional (all p<0.05). Generally, low fT3 patients demonstrated less improvement in Physical Component Score (PCS) (p=0.008) and Mental Component Score (MCS) (p=0.001). The percentage of patients reaching MCID for PCS and MCS was lower in low fT3 group than that in normal fT3 group (p<0.001). Multivariate linear regression analyses showed that low level of fT3 was an independent risk factor for PCS and MCS improvements. In conclusion, a low fT3 level is a predictor of worse HRQOL improvement in ACS patients treated with DES.

show abstract

Fatigue in Patients With Coronary Artery Disease

Abstract: In coronary artery disease patients, increased thyroid hormone concentrations are associated with decreased physical fatigue and decreased exertion fatigue, and increased cortisol concentrations with decreased mental fatigue. Exercise capacity is not associated with endocrine factors.

Cited by 19 publications

References 42 publications

A quantile regression approach to explain the relationship of Fatigue and Cortisol, Cytokine among Koreans with Hepatitis B

A quantile regression approach to explain the relationship of Fatigue and Cortisol, Cytokine among Koreans with Hepatitis B

Diurnal Cortisol Rhythm Is Associated With Adverse Cardiac Events and Mortality in Coronary Artery Bypass Patients

Low fT3 is associated with diminished health-related quality of life in patients with acute coronary syndrome treated with drug-eluting stent: a longitudinal observational study

Contact Info

Product

Resources

About