Low fT3 is associated with diminished health-related quality of life in patients with acute coronary syndrome treated with drug-eluting stent: a longitudinal observational study

Xue, Chao; Bian, Ling; Xie, Yu; Yin, Zhao; Xu, Zhigang; Chen, Qi Zhi; Zhang, Hui Li; Yang, Fan; Du, Rong; Wang, Chang Qian

doi:10.18632/oncotarget.21811

Cited by 11 publications

(10 citation statements)

References 43 publications

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“…A study on mild cognitive impairment and dementia showed that patients with relatively high T3 levels showed impairment in memory and visuospatial and executive functions [73]. However, patients with acute coronary syndrome having low T3 levels had a poorer health-related quality of life (including general health, social functioning, and role emotional) than those with normal levels at a 1-year follow-up [74]. A study on subjective cognitive decline showed that higher T3 levels were associated with better verbal memory performance (immediate and delayed recall tasks) in APOE ε4 carriers [75].…”

Section: Discussionmentioning

confidence: 99%

Association of Lipoprotein and Thyroid Hormones With Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus

Kong

Zhou

et al. 2020

Preprint

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Background: Neuropsychiatric systemic lupus erythematosus (NPSLE) occurs up to 75% of adult SLE patients, and is one of the major causes of death in SLE patients. Cognitive dysfunction is a typical clinical feature of NPSLE, which seriously affects the quality of life of patients. Dyslipidemia and thyroid disease, which were prevalent in SLE patients, both related to the neuropsychiatric disturbances, including significant psychiatric and cognitive disturbance. This study aimed to investigate whether cognitive dysfunction in patients with systemic lupus erythematosus (SLE) was related to the expression of serum thyroid hormone and lipoproteins.Methods: A total of 121 patients with SLE and 65 healthy controls (HCs) at Nanjing Drum Tower Hospital completed a cognitive function test, then 81 SLE patients were divided into high cognition (n=33) group and low cognition group (n=48). The differences in clinical and laboratory tests and the correlations between IgG, IgM, albumin, T3, and T4 levels and cognitive function were analyzed. The enzyme-linked immunosorbent assay was used to determine the serum levels of 4 lipoproteins (APOE, APOA1, IGF-1, and IGFBP7) in 81 patients.Results: Patients with SLE were less educated with abnormal cognitive function compared with HCs. The levels of albumin, T3 (P < 0.05), and T4 decreased in low-cognition patients, while D-dimer, anti-dsDNA antibody, and IgM levels increased. The serum IgG and IgM levels showed a significant negative correlation with partial cognitive function. The serum T3 and T4 levels positively correlated with cognition. The expression of APOE, APOA1, IGF-1, and IGFBP7 showed no difference between the high- and low-cognition groups. However, the serum APOE level negatively correlated with Line Orientation, APOA1 positively correlated with Coding, and IGFBP7 negatively correlated with Graphic copy (P < 0.05), and IGF-1 had no correlation with any cognitive functions.Conclusions: Thyroid hormones (T3 and T4) and lipoproteins (APOE, APOA1, and IGFBP7) were associated with cognitive dysfunction in SLE. Whether T3 and T4 can be used in clinical practice as the biomarkers of cognitive dysfunction in SLE needs further exploration.

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Section: Discussionmentioning

confidence: 99%

Association of Lipoprotein and Thyroid Hormones With Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus

Kong

Zhou

et al. 2020

Preprint

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Section: Acute Myocardial Infarction (Ami) Is a Leading Cause O F M O R B I D I T Y A N D M O R T A L I T Y W O R L D W I D E ( 1 )mentioning

confidence: 97%

“…The literature suggests an inverse relationship between serum BNP and serum T3 levels in patients without hyperthyroidism (18). We hypothesized that low T3 status could serve as a prognostic indicator in AMI since there is a negative relationship between fT3 and NT-pro-BNP (18). Therefore, the aims of this study were to investigate the association between low fT3 levels and prognosis and the relationship between fT3 and NT-pro-BNP levels in patients with AMI.…”

Section: Acute Myocardial Infarction (Ami) Is a Leading Cause O F M O R B I D I T Y A N D M O R T A L I T Y W O R L D W I D E ( 1 )mentioning

confidence: 98%

“…The reference ranges used by our laboratory were as follows: TT3, 0.65-1.91 ng/mL; TT4, 4.29-12.47 μg/mL; fT3, 1.79-4.09 pg/mL; fT4, 0.80-1.88 ng/dL;and TSH, 0.55-4.78 μIU/mL. The patients were divided into a low fT3 group (fT3 <2.5 pg/mL, n=252) and a normal fT3 group (fT3 ≥2.5 pg/mL, n=561) (18). NT-proBNP levels were determined using ELISA kits (Biomedica, Austria), and the assay range was 0-6,000 pg/mL.…”

Section: Biochemistrymentioning

confidence: 99%

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Prognostic value of free triiodothyronine and N-terminal pro-B-type natriuretic peptide for patients with acute myocardial infarction undergoing percutaneous coronary intervention: a prospective cohort study

Wang¹,

Wang²,

Zhang³

et al. 2021

Ann Transl Med

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Background: Altered thyroid function and increased N-terminal pro-B-type natriuretic peptide (NT-proBNP) are prognostic factors in acute myocardial infarction (AMI). The study aims to investigate whether free triiodothyronine (fT3) and NT-proBNP are prognostic factors for long-term outcomes in patients with AMI undergoing percutaneous coronary intervention (PCI).Methods: This was an observational, prospective, single-center study of consecutive patients enrolled at Fuwai Hospital between January, 2013 and December, 2013. The patients were divided into two groups according to fT3 levels: low fT3 (<2.5 pg/mL) and normal fT3 (2.50-4.09 pg/mL). The primary outcome of this study was the incidence of major adverse cardiovascular events (MACEs).Results: There were 252 patients with low fT3 and 561 patients with normal fT3. After >2 years of follow-up, patients with low fT3 levels had higher rates of MACEs than those with normal fT3 (27.0% vs. 7.8%, P<0.001). Univariable Cox proportional hazards regression analyses showed that NT-proBNP >802.7 pg/mL [hazard ratio (HR) =5.063, 95% confidence interval (CI): 3.176-8.071, P<0.001] and fT3 <2.5 pg/mL (HR =3.867, 95% CI: 2.646-5.651, P<0.001) were the strongest predictors of MACEs.After adjustment for traditional risk predictors, fT3 <2.5 pg/mL (HR =2.570, 95% CI: 1.653-3.993, P<0.001) was one of the most important independent predictors of MACEs. Patients with NT-proBNP ≤802.7 pg/mL and fT3 ≥2.5 pg/mL had the best prognosis, while patients with NT-proBNP >802.7 pg/mL and fT3 <2.5 pg/mL had the worst outcomes (P<0.001).Conclusions: Low fT3 is a strong predictor of poor prognosis after AMI. The fT3+NT-proBNP combination might be a valuable predictor of the long-term outcomes of PCI after AMI.

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“…Ö³ çì³íè ôóíêö³¿ îñ³ «ã³ïîòàëàìóñ-ã³ïîô³ç-ùèòî-ïîä³áíà çàëîçà» íàçèâàþòüñÿ ñèíäðîìîì «íèçüêîãî» òðèéîäòèðîí³íó. Ïåðåäáà÷àºòüñÿ, ùî äàíèé ñòàí ìîaeå áóòè àäàïòèâíèì êîìïåíñàòîðíèì ìåõàí³çìîì äëÿ çáåðåaeåííÿ ñïîaeèâàííÿ åíåðã³¿ òà âåëè÷èíà çì³íè êîíöåíòðàö³¿ T 3 âàð³þº çàëåaeíî â³ä òÿaeêîñò³ çàõâîðþâàííÿ [9]. Ó [10][11][12] êðèòåð³ºì âèçíà÷åííÿ ñèíäðîìó «íèçüêîãî» òðèéîäòèðîí³íó º íèaeíÿ ìåaeà íîðìè Ò 3â ( 2,5 ïìîëü/ë) çà íîðìàëüíèõ ð³âí³â Ò 4â ³ ÒÒÃ.…”

Section: ðåçóëüòàòè äîñë³äAeåííÿunclassified

Модель Несприятливого Перебігу Серцевої Недостатності З Урахуванням Тиреоїдного Статусу Хворих

Pyvovar¹

2020

МСЗ

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Обстежено 157 пацієнтів із серцевою недостатністю (СН) – перенесеним інфарктом міокарда, у яких визначали предиктори несприятливого перебігу захворювання залежно від тиреоїдного статусу. При госпіталізації проведено стандартизоване оцінювання стану, визначено показники внутрішньосерцевої гемодинаміки, клінічного й біохімічного аналізів крові, рівні гормонів щитоподібної залози. Установлено, що ризик повторної госпіталізації хворих на СН із приводу декомпенсації захворювання зростає за перевищення оптимальної точки поділу для сироваткового рівня вільного трийодтироніну ≤ 2,07 пмоль/л. Відносний ризик повторної госпіталізації хворих із СН протягом 2 років при рівні вільного трийодтироніну ≤ 2,07 пмоль/л становить 2,224 [1,363–3,630] (p<0,05). За допомогою автоматичного регресійного аналізу побудовано модель повторної госпіталізації пацієнтів із СН у зв’язку з декомпенсацією захворювання протягом 2 років. До неї ввійшли такі показники: маса тіла, рівень вільного трийодтироніну, наявність нетоксичного зобу, рівні холестерину ліпопротеїдів низької щільності й загального холестерину, відносний вміст гранулоцитів у крові, концентрація вільного тироксину. За даними ROC-аналізу, ризик розвитку повторної госпіталізації хворих із СН у зв’язку з декомпенсацією захворювання зростає при перевищенні оптимальної точки поділу для значення рівняння регресійної моделі ≥ 1,321 ум. од. У зв’язку з тим що зниження сироваткового рівня трийодтироніну впливає на перебіг СН, можна припустити доцільним використання його значення ≤ 2,07 пмоль/л як предиктора несприятливого перебігу захворювання.

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Low fT3 is associated with diminished health-related quality of life in patients with acute coronary syndrome treated with drug-eluting stent: a longitudinal observational study

Cited by 11 publications

References 43 publications

Association of Lipoprotein and Thyroid Hormones With Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus

Association of Lipoprotein and Thyroid Hormones With Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus

Prognostic value of free triiodothyronine and N-terminal pro-B-type natriuretic peptide for patients with acute myocardial infarction undergoing percutaneous coronary intervention: a prospective cohort study

Модель Несприятливого Перебігу Серцевої Недостатності З Урахуванням Тиреоїдного Статусу Хворих

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