Encapsulation of silver particles using co-axial jetting

Samarasinghe, S. R.; Balasubramanian, K.; Edirisinghe, Mohan

doi:10.1007/s10854-007-9278-5

Cited by 9 publications

(4 citation statements)

References 26 publications

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“…Coaxial electrospinning is able to expand the capability of electrospinning in fabricating nanofibers in two manners. The first one is that it can prepare nanofibers from materials that lack filament-forming properties using traditional coaxial electrospinning process, where the sheath fluid often has good electrospinnability while the core fluid is unelectrospinnable (21)(22)(23). The second one is a modified coaxial electrospinning process first reported by Yu et al (24,25), where only unspinnable solvent is employed as sheath fluid.…”

Section: Introductionmentioning

confidence: 99%

Drug-Loaded Zein Nanofibers Prepared Using a Modified Coaxial Electrospinning Process

Huang

Zou

et al. 2013

AAPS PharmSciTech

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Abstract. This study investigated the preparation of drug-loaded fibers using a modified coaxial electrospinning process, in which only unspinnable solvent was used as sheath fluid. With zein/ibuprofen (IBU) co-dissolving solution and N, N-dimethylformamide as core and sheath fluids, respectively, the drug-loaded zein fibers could be generated continuously and smoothly without any clogging of the spinneret. Field emission scanning electron microscopy and transmission electron microscopy observations demonstrated that the fibers had ribbon morphology with a smooth surface. Their average diameters were 0.94±0.34 and 0.67±0.21 μm when the sheath-to-core flow rate ratios were taken as 0.11 and 0.25, respectively. X-ray diffraction and differential scanning calorimetry verified that IBU was in an amorphous state in all fiber composites. Fourier transform infrared spectra showed that zein had good compatibility with IBU owing to hydrogen bonding. In vitro dissolution tests showed that all the fibers could provide sustained drug release files via a typical Fickian diffusion mechanism. The modified coaxial electrospinning process reported here can expand the capability of electrospinning in generating fibers and provides a new manner for developing novel drug delivery systems.

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Section: Introductionmentioning

confidence: 99%

Drug-Loaded Zein Nanofibers Prepared Using a Modified Coaxial Electrospinning Process

Huang

Zou

et al. 2013

AAPS PharmSciTech

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“…Successful control of the resulting fiber morphology and diameter is governed by a delicate balance between the process and solution parameters . A more complex variant of this technique, called coelectrospinning (or coaxial electrospinning), − typically uses two concentric nozzles to form fibers with a core material encapsulated within a different shell material, which must be polymeric or viscoelastic . Coelectrospinning can produce multiphase submicrometer structures in an efficient, scalable, one-step synthesis, such that it has already gained attention for a variety of applications including biomedicine (tissue engineering, controlled drug release systems), ,, filter systems, catalysis, optical applications (waveguides), or as nanocables for microelectronics .…”

Section: Introductionmentioning

confidence: 99%

A Solution Selection Model for Coaxial Electrospinning and Its Application to Nanostructured Hydrogen Storage Materials

et al. 2010

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Coaxial electrospinning was used to encapsulate the complex hydride ammonia borane in polystyrene to improve its properties as a hydrogen storage material. A solvent selection system was developed by using the Hansen solubility parameters to facilitate the choice of compatible solvents for core and shell. This enabled systematic optimization of the parameters needed for successful coelectrospinning. This approach has general application for any multiphase electrospinning system, including ones where the core is highly conducting or nonpolymeric. The resulting fiber morphologies depend strongly on the degree of miscibility of core and shell solutions. Fibers spun from immiscible core-shell solutions had a classic coaxial structure. Fibers produced from semimiscible core-shell solutions were highly porous, with inclusions extending through the fiber and an ordered radial and longitudinal distribution of nanoscale pores on the fiber surface. We suggest that this type of porosity may be due to an instability created in the nonaxisymmetric modes at the core-shell interface, resulting in intrusion of the core into the shell polymer. These controllably porous structures have numerous potential applications including materials templating or drug delivery. In the porous fibers, the temperature of the first hydrogen release of ammonia borane is reduced to 85 °C. This result suggests a nanostructured hydride, but a large mass loss indicates that much of the ammonia borane is expelled on heating. The coaxial fibers, in contrast, appear to encapsulate the hydride successfully. The coaxial and porous fibers alike showed no significant release of borazine, suggesting two different suppression mechanisms for this impurity.

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“…A further significant feature of this technique is its ability to generate particles with a narrow size distribution, and a mean diameter that can be varied between hundreds of micrometres and tens of nanometres by varying the processing parameters for a particular system, e.g. flow rate(s), needle diameter(s) and applied voltage (Yeo et al 2005;Ahmad et al 2008;Samarasinghe et al 2008;Xie et al 2008) as well as the chemical composition and concentration of the encapsulating polymer solution.…”

Section: Introductionmentioning

confidence: 99%

One-step electrohydrodynamic production of drug-loaded micro- and nanoparticles

Enayati

Ahmad

Stride

et al. 2009

J. R. Soc. Interface.

100

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The objective of this work was to produce drug-loaded nanometre-and micrometre-scale particles using a single-step process that provides control over particle size and size distribution. Co-axial electrohydrodynamic processing was used, at ambient temperature and pressure, with poly(lactic-co-glycolic acid) as the polymeric coating material and oestradiol as the encapsulated drug. The particle diameter was varied from less than 120 nm to a few micrometres, by simple methodical adjustments in the processing parameters ( polymer concentration and applied voltage). In vitro studies were performed to determine the drug release profile from the particles during unassisted and ultrasound-stimulated degradation in simulated body fluid. An encapsulation efficiency of approximately 70% was achieved and release of the drug was sustained for a period of over 20 days. Exposing the particles to ultrasound (22.5 kHz) increased the rate of release by approximately 8 per cent. This processing method offers several advantages over conventional emulsification techniques for the preparation of drug-loaded particles. Most significantly, process efficiency and the drug's functionality are preserved, as complex multistep processing involving harsh solvents, other additives and elevated temperatures or pressures are avoided. Production rates of 10 12 particles min 21 can be achieved with a single pair of co-axial needles and the process is amenable to being scaled up by using multiple sets.

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Encapsulation of silver particles using co-axial jetting

Cited by 9 publications

References 26 publications

Drug-Loaded Zein Nanofibers Prepared Using a Modified Coaxial Electrospinning Process

Drug-Loaded Zein Nanofibers Prepared Using a Modified Coaxial Electrospinning Process

A Solution Selection Model for Coaxial Electrospinning and Its Application to Nanostructured Hydrogen Storage Materials

One-step electrohydrodynamic production of drug-loaded micro- and nanoparticles

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