Drug-Loaded Zein Nanofibers Prepared Using a Modified Coaxial Electrospinning Process

Abstract

Abstract. This study investigated the preparation of drug-loaded fibers using a modified coaxial electrospinning process, in which only unspinnable solvent was used as sheath fluid. With zein/ibuprofen (IBU) co-dissolving solution and N, N-dimethylformamide as core and sheath fluids, respectively, the drug-loaded zein fibers could be generated continuously and smoothly without any clogging of the spinneret. Field emission scanning electron microscopy and transmission electron microscopy observations demonstrated that the fibers had ribbon morphology with a smooth surface. Their average diameters were 0.94±0.34 and 0.67±0.21 μm when the sheath-to-core flow rate ratios were taken as 0.11 and 0.25, respectively. X-ray diffraction and differential scanning calorimetry verified that IBU was in an amorphous state in all fiber composites. Fourier transform infrared spectra showed that zein had good compatibility with IBU owing to hydrogen bonding. In vitro dissolution tests showed that all the fibers could provide sustained drug release files via a typical Fickian diffusion mechanism. The modified coaxial electrospinning process reported here can expand the capability of electrospinning in generating fibers and provides a new manner for developing novel drug delivery systems.

Structural and Surface Compatibility Study of Modified Electrospun Poly(ε-caprolactone) (PCL) Composites for Skin Tissue Engineering

“…Since 1930s (6), the electrospinning process is being widely used for scaffold preparation from different polymers. It produces micro-to nanofibrous-based scaffolds with desired porosity, biocompatibility, and enhanced specific surface area and also with proper mechanical stability (9). So structurally, chemically, and mechanically, these electrospun scaffolds bear a resemblance-like extracellular matrix (ECM) of tissues (10).…”

Nanofibers and Applications as Colon Specific Drug Delivery System

“…J Lit Pharm Sci 2018;7(1): [11][12][13][14][15][16][17][18][19][20][21][22][23] zünme testleri de asidik ortamda formülasyonun etken madde salımını imkânsız kıldığını, nötral pH'de ise birbirini izleyen 2 aşamalı bir salım olduğunu göstermektedir. Birinci aşamada kabuğu oluşturan Eudragit ® S100 çözünmekte ve diklofenak sodyumun bir kısmı serbest forma dönüşmek-tedir.…”

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Yasin TURANLI ve ark.J Lit Pharm Sci 2018;7(1): [11][12][13][14][15][16][17][18][19][20][21][22][23] 12 ŞEKİL 1: Basit bir elektro-çekim düzeneği (Şekil tarafımızca çizilmiştir). Bu avantajlar, nanoliflerin birçok endüstri alanına rahatlıkla girmesine ve potansiyel kullanım alanı sağlamasına izin vermektedir.

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Acute Pain Management in the Emergency Department: Emphasis on NSAIDs

“…Development continues today both in the discovery of new molecules [123,124] and in the creation of improved formulations. Among the new technologies are topical formulations [125], aerogels [126], transdermal patches [127], microparticle technologies [128] and drug-loaded nanofibers [129].…”