Abstract. This study investigated the preparation of drug-loaded fibers using a modified coaxial electrospinning process, in which only unspinnable solvent was used as sheath fluid. With zein/ibuprofen (IBU) co-dissolving solution and N, N-dimethylformamide as core and sheath fluids, respectively, the drug-loaded zein fibers could be generated continuously and smoothly without any clogging of the spinneret. Field emission scanning electron microscopy and transmission electron microscopy observations demonstrated that the fibers had ribbon morphology with a smooth surface. Their average diameters were 0.94±0.34 and 0.67±0.21 μm when the sheath-to-core flow rate ratios were taken as 0.11 and 0.25, respectively. X-ray diffraction and differential scanning calorimetry verified that IBU was in an amorphous state in all fiber composites. Fourier transform infrared spectra showed that zein had good compatibility with IBU owing to hydrogen bonding. In vitro dissolution tests showed that all the fibers could provide sustained drug release files via a typical Fickian diffusion mechanism. The modified coaxial electrospinning process reported here can expand the capability of electrospinning in generating fibers and provides a new manner for developing novel drug delivery systems.
Two types of novel benzoxazine-based phenolic resins from phenol-furfural (PFB) and cardanol-furfural (CFB) resins had been synthesized and the highly thermally stable polybenzoxazines were obtained by the thermal cure of the corresponding benzoxazine-based phenolic resins. The chemical structure of benzoxazine-based phenolic resins derived from renewable resources was confirmed by Fourier transform infrared (FTIR), 1 H NMR, and gel permeation chromatography (GPC). FTIR spectrum and differential scanning calorimetry (DSC) showed that the monomers were thermally initiated and polymerized via ring-opening polymerization. Thermogravimetric analysis indicated that the incorporation of furan groups could enhance the char yield and thermal stability. However, the long alkyl side chain from cardanol could increase the toughness, while decreasing the char yield and thermal stability.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.