Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells

Wang, Lu; Xu, Xiaoping; Zhang, Yi; Zhang, Yuanqing; Zhu, Ying; Shi, Jiye; Sun, Yanhong; Huang, Qing

doi:10.1007/s10856-013-4969-3

Cited by 48 publications

(20 citation statements)

References 23 publications

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“…These findings suggest that curcumin has been successfully encapsulated into the HNT lumen. Similar results are reported in literature for the encapsulation of curcumin within poly(amidoamine) dendrimers (Wang et al, 2013).…”

Section: Interactions Between Hnt and Curcuminsupporting

confidence: 91%

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

Riela

Massaro

Colletti

et al. 2014

International Journal of Pharmaceutics

109

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Section: Interactions Between Hnt and Curcuminsupporting

confidence: 91%

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

Riela

Massaro

Colletti

et al. 2014

International Journal of Pharmaceutics

109

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“…Dendrimers have been used as passive anticancer nanocarriers [365,369,370,[377][378][379]. An early example of in vivo passive targeting Is the conjugation of a sodium carboxyl-terminated G-3.5 polyamidoamine (PAMAM) dendrimer with cisplatin for the treatment of B16F10 induced melanomas, achieving an enhanced antitumor efficacy compared with the free drug [372].…”

Section: Polymeric Nanocarriersmentioning

confidence: 99%

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Pérez-Herrero

Fernández‐Medarde

2015

European Journal of Pharmaceutics and Biopharmaceutics

1,403

754

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Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases. It is characterized by uncontrolled cell proliferation and an absence of cell death that, except for hematological cancers, generates an abnormal cell mass or tumor. This primary tumor grows thanks to new vasculatization and, in time, adquires metastatic potential and spreads to other body sites, which causes metastasis and finally death. Cancer is caused by damage or mutations in the genetic material of the cells due to environmental or inherited factors. While surgery and radiotherapy are the primary treatment used for local and non-metastatic cancers, anti-cancer drugs (chemotherapy, hormone and biological therapies) are the choice currently used in metastasic cancers. Chemotherapy is based on the inhibition of the division of rapidly growing cells, which is a characteristic of the cancerous cells, but unfortunately, it also affects normal cells with fast proliferation rates, like the hair follicles, bone marrow and gastrointestinal tract cells, generating the characteristic side effects of chemotherapy. The indiscriminate destruction of normal cells, the toxicity of conventional chemotherapeutic Código de campo cambiado

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“…121 More examples of herbal loaded NE are presented in Table 1. [122][123][124][125][126][127][128] However, many other dendrimers such as polyamidoamine organosilicon (PAMAMOS), polypropyleneimine (PPI), and glycodendrimers have been developed and studied but with less common use. 120…”

Section: Transferosomementioning

confidence: 99%

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Rahman

Othman

Hammadi

et al. 2020

IJN

145

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Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

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Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells

Cited by 48 publications

References 23 publications

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

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