Enantiospecific pharmacokinetics of intravenous dexmedetomidine in beagles

Abstract

and also has analgesic properties (Siegenthaler et al., 2020). It can be administered as a single enantiomer, or as a racemic mixture together with levomedetomidine [(S)-(−)-medetomidine] ("medetomidine"). Clear clinical advantages of using the single enantiomer over the racemate are under debate. Although some studies found the effects of the two products similar (Gómez-Villamandos et al., 2006;