Pharmacokinetics and pharmacodynamics of intravenous dexmedetomidine (2 μg∙kg−1) in dogs.

de Sant'Ana Alves, Larissa; Arcoverde, Kathryn Nóbrega; de Oliveira, Caio Vinícius Almeida; Cavalcante, Jerson Marques; Araújo-Silva, Gabriel; de Paula, Valéria Veras

doi:10.1016/j.rvsc.2024.105229

Research in Veterinary Science

2024

DOI: 10.1016/j.rvsc.2024.105229

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Pharmacokinetics and pharmacodynamics of intravenous dexmedetomidine (2 μg∙kg−1) in dogs.

Larissa de Sant'Ana Alves,

Kathryn Nóbrega Arcoverde,

Caio Vinícius Almeida de Oliveira

et al.

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Clinical Effects and Pharmacokinetic Profile of Intramuscular Dexmedetomidine (10 μg/kg) in Cats

Fernandes,

Passos,

Arcoverde

et al. 2024

Animals

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This study investigated the pharmacokinetic profile of and pharmacodynamic response to dexmedetomidine administered intramuscularly (IM) at a dose of 10 μg/kg in healthy cats. Nine adult cats were evaluated before and after administration of the drug, with serial collections of plasma samples. Dexmedetomidine induced deep sedation, with a rapid onset of action and a duration of one hour, reaching a peak between 20 and 30 min after administration. The half-life (T½) was 70.2 ± 48 min, with a maximum concentration (Cmax) of 2.2 ± 1.9 ng/mL and time to reach maximum concentration (Tmax) of 26.4 ± 19.8 min. The area under the curve (AUC) was 167.1 ± 149.1 ng/mL*min, with a volume of distribution (Vd) of 2159.9 ± 3237.8 mL/kg and clearance (Cl) of 25.8 ± 33.0 mL/min/kg. There was a reduction in heart rate (HR) and respiratory rate (RR) in relation to the baseline, with a slight decrease in systolic (SBP), diastolic (DBP), and mean (MAP) blood pressure in the first hour. Blood glucose increased after 60 min. Dexmedetomidine proved to be effective and safe, with rapid absorption, metabolization, and elimination, promoting good sedation with minimal adverse effects after IM administration in healthy cats.

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Clinical Effects and Pharmacokinetic Profile of Intramuscular Dexmedetomidine (10 μg/kg) in Cats

Fernandes,

Passos,

Arcoverde

et al. 2024

Animals

View full text Add to dashboard Cite

show abstract

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Pharmacokinetics and pharmacodynamics of intravenous dexmedetomidine (2 μg∙kg−1) in dogs.

Cited by 1 publication

References 23 publications

Clinical Effects and Pharmacokinetic Profile of Intramuscular Dexmedetomidine (10 μg/kg) in Cats

Clinical Effects and Pharmacokinetic Profile of Intramuscular Dexmedetomidine (10 μg/kg) in Cats

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