Enantioseparation of β-blockers with two chiral centers by capillary electrophoresis using sulfated β-cyclodextrins

Tamisier-Karolak, Sara L.; Stenger, Marie-Anne; Bommart, Alexandre

doi:10.1002/(sici)1522-2683(19990901)20:13<2656::aid-elps2656>3.0.co;2-6

Cited by 47 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several chiral applications using anionic CDs as chiral selectors have utilized the reversed-polarity mode, under conditions of suppressed electroosmotic flow [20][21][22][23][24][25][26][27][28][29][30]. Some of these applications have made comparisons of peak shape and the resolution in normal-polarity mode versus reversed-polarity mode and have found more optimum separations for certain solutes using the later technique [29,30].…”

Section: Mode (Iii): High Su(xiii)-ã-cd Concentration At Low Ph In Thmentioning

confidence: 99%

The use of a highly sulfated cyclodextrin for the simultaneous chiral separation of amphetamine-type stimulants by capillary electrophoresis

et al. 2002

View full text Add to dashboard Cite

We investigated the simultaneous chiral separation of nine amphetamine type stimulants (dl-norephedrine, dl-norpseudoephedrine, dl-ephedrine, dl-pseudoephedrine, dl-amphetamine, dl-methamphetamine, dl-methylenedioxyamphetamine (MDA), dl-methylenedioxymethamphetamine (MDMA), and dl-methylenedioxyethylamphetamine (MDEA)) by capillary electrophoresis using highly sulfated gamma-cyclodextrin (SU(XIII)-gamma-CD) as a chiral selector. Three different approaches using SU(XIII)-gamma-CD with 50 mM phosphate background electrolyte were designed; (I) high CD concentration (10 mM SU(XIII)-gamma-CD) at neutral pH (pH 7.0) in the normal polarity mode, (II) low CD concentration (1.0 mM) at low pH (pH 2.6) in the normal polarity mode and (III) high CD concentration at low pH (pH 2.6) in the reversed-polarity mode. In mode (II), the effects of adding three neutral CDs (beta-CD, dimethyl-beta-CD and hydroxypropyl-beta-CD) were also investigated. The best separation was obtained after optimizing mode (III) as follows: run buffer of 10 mM SU(XIII)-gamma-CD with 50 mM phosphate background electrolyte at pH 2.6, applied voltage of -12 kV and capillary temperature of 15 degrees C.

show abstract

Section: Mode (Iii): High Su(xiii)-ã-cd Concentration At Low Ph In Thmentioning

confidence: 99%

The use of a highly sulfated cyclodextrin for the simultaneous chiral separation of amphetamine-type stimulants by capillary electrophoresis

et al. 2002

View full text Add to dashboard Cite

show abstract

“…CDs makes it possible to adjust the enantiomeric migration order by changing the pH of the BGE [87,88]. The high enantiomeric selectivity of charged CDs makes it feasible to use the short-end injection mode, i.e., to inject the analyte in the detection side of the capillary, in order to reduce the analysis time [89,90].…”

Section: Charged Cdsmentioning

confidence: 99%

“…The recent application and introduction of new charged derivatives of CDs in analytical practice during the past two years is reflected in several papers, as follows. Anionic b-CDs, i.e., SBE-b-CD and HDAS-b-CD, were used to separate enantiomers of pharmaceuticals [87], tropaalkaloids [91], analgethic drug candidates [93], ormexifene analogues [89], and amino acid derivatives [41,95]. SBEb-CD was found to be better than neutral and other anionic b-CDs.…”

Section: Charged Cdsmentioning

confidence: 99%

“…Enantioseparation of atropine in plan-extract [40], bblockers [87], dihydroxyphenylalanine (DOPA), methlyldihydroxyphenylalanine (MDOPA) and hydrozinomethyldihydroxy-phenylalanine (CDOPA) [98] and triazole fungicides [99] were achieved employing sulfated b-CDs. No enantioseparation of atropine [40] was observed using neutral CDs, i.e., a-CD, HP-b-CD, g-CD, methyl-b-CD and DM-b-CD as chiral selectors.…”

Section: Charged Cdsmentioning

confidence: 99%

See 1 more Smart Citation

Recent developments in chiral capillary electrophoresis and applications of this technique to pharmaceutical and biomedical analysis

Ahmad

2001

Electrophoresis

186

View full text Add to dashboard Cite

This paper provides an overview of the current status of chiral capillary electrophoresis (CE). The emphasis is placed on the application of CE in chiral separation of various racemic compounds. During the last two years about 280 papers, several review articles, and two entire issues, edited by S. Fanali (Electrophoresis 1999, 20, 2577-2798, and H. Nishi and S. Terabe (J. Chromatogr. A 2000, 879, 1-471.) have been devoted to chiral CE. Enantiomeric separations of various compounds, e.g., pharmaceuticals, drug candidates, drugs and related metabolites in biological fluids, amino acids, di- and tri peptides, pesticides and fungicides, have been performed using different chiral selectors. Native and derivatized cyclodextrins continue to be the most widely used chiral selectors. Other chiral selectors such as natural and synthetic chiral micelles, crown ethers, chiral ligands, proteins, oligo- and polysaccharides, and macrocyclic antibiotics have also been applied to chiral CE separations.

show abstract

“…Enantioseparation of labetalol was achieved by different chiral selectors in both aqueous and nonaqueous CE [14, 18 -24]. Recently, separation of four isomers of nadolol in S-b-CD at low pH (pH = 2.5) (DS = 7 -11) was also reported [25]. However, only a limited number of compounds with multiple chiral centers has been studied so far.…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic chiral separation of pharmaceutical compounds with multiple stereogenic centers in charged cyclodextrin media

Fang¹,

Dowling

Bicker

et al. 2001

J. Sep. Science

View full text Add to dashboard Cite

Enantioseparation of β-blockers with two chiral centers by capillary electrophoresis using sulfated β-cyclodextrins

Cited by 47 publications

References 29 publications

The use of a highly sulfated cyclodextrin for the simultaneous chiral separation of amphetamine-type stimulants by capillary electrophoresis

The use of a highly sulfated cyclodextrin for the simultaneous chiral separation of amphetamine-type stimulants by capillary electrophoresis

Recent developments in chiral capillary electrophoresis and applications of this technique to pharmaceutical and biomedical analysis

Electrophoretic chiral separation of pharmaceutical compounds with multiple stereogenic centers in charged cyclodextrin media

Contact Info

Product

Resources

About