Recent developments in chiral capillary electrophoresis and applications of this technique to pharmaceutical and biomedical analysis

Abstract

This paper provides an overview of the current status of chiral capillary electrophoresis (CE). The emphasis is placed on the application of CE in chiral separation of various racemic compounds. During the last two years about 280 papers, several review articles, and two entire issues, edited by S. Fanali (Electrophoresis 1999, 20, 2577-2798, and H. Nishi and S. Terabe (J. Chromatogr. A 2000, 879, 1-471.) have been devoted to chiral CE. Enantiomeric separations of various compounds, e.g., pharmaceuticals, drug candidates, drugs and related metabolites in biological fluids, amino acids, di- and tri peptides, pesticides and fungicides, have been performed using different chiral selectors. Native and derivatized cyclodextrins continue to be the most widely used chiral selectors. Other chiral selectors such as natural and synthetic chiral micelles, crown ethers, chiral ligands, proteins, oligo- and polysaccharides, and macrocyclic antibiotics have also been applied to chiral CE separations.

Simultaneous Chiral Analysis of Methamphetamine and Related Compounds by Capillary Electrophoresis/Mass Spectrometry Using Anionic Cyclodextrin

“…In addition, the opposite direction of mobility of the charged CD and oppositely charged enantiomers results in sample stacking, which improves the separation of the enantiomers. 10 Therefore, anionic CDs should produce higher chiral separation of cationic analytes than neutral CDs. In recent years, anionic CDs were used in the chiral analysis of some ATS by CE.…”

(S)-(+)-2-Octanol as a Chiral Oil Core for the Microemulsion Electrokinetic Chromatographic Separation of Chiral Basic Drugs

“…Since chiral resolution was first described in CE by Zare and co-workers, 1,2 many CE enantioseparation methods have been reported, as previously reviewed. [3][4][5][6][7][8][9][10] These methods are based on several resolution mechanisms, such as ligand-exchange, inclusioncomplexation, ion-pair interactions, micellar electrokinetic chromatography (MEKC) and microemulsion electrokinetic chromatography (MEEKC). MEEKC has several optimization advantages over other techniques in terms of selectivity, 11 elution range and composition.…”

Chiral pollutants and their significance in the environment

“…Kiral farmasötiklerin enantiyomerik ayrımında genellikle optik izomerlerin ayrımı doğrudan ve dolaylı olmak üzere iki şekilde gerçekleştirilmektedir. Kiral kapiler elektroforezde doğrudan ayrım yöntemi en fazla tercih edilen yöntemdir [35]. Çevresel örneklerde yapılan kiral analizlerde en fazla kullanılan yöntemler gaz kromatografisi (GC), sıvı kromatografisi (LC) ve kapiler elektroforez (CE)'dir [13].…”