which may, in turn, confer increased risk for smoking relapse in those with higher levels of symptomatology of both disorders.
IntroductionCigarette smoking co-occurs with a broad range psychiatric disorders ( Lasser et al., 2000 ). Individuals with posttraumatic stress disorder (PTSD) or attention-defi cit hyperactivity disorder (ADHD) endorse rates of smoking two to three times higher ( Beckham et al., 1995 ; Breslau, Davis, & Schultz, 2003 ;Lambert & Hartsough, 1998 ;Lasser et al., 2000 ;Milberger, Biederman, Faraone, Chen, & Jones, 1997 ;Molina & Pelham, 2003 ;Pomerleau, Downey, Stelson, & Pomerleau, 1995 ) and have more diffi cultly quitting than nondiagnosed samples ( Covey, Manubay, Jiang, Nortick, & Palumbo, 2008 ;Humfl eet et al., 2005 ;Lasser et al., 2000 ). Further more , subclinical ADHD symptoms are associated with increased risk for smoking ( Kollins, McClernon, & Fuemmeler, 2005 ).Dysregulated affective functioning has been proposed as a potential mechanism underlying the risk for smoking in both PTSD and ADHD, which are frequently comorbid themselves ( Adler, Kunz, Chua, Rotrosen, & Resnick, 2004 ; Cook, McFall, Calhoun, & Beckham, 2007 ;Gehricke et al., 2007 ;Hurtig et al., 2007 ;Kessler et al., 2006 ;McClernon & Kollins, 2008 ;Park et al., 2011 ;Smalley et al., 2007 ). However, no studies have assessed the association of ADHD symptoms with smoking that also consider PTSD symptoms or includes individuals with PTSD. It is possible that PTSD and ADHD are associated with nicotine dependence via shared affective mechanisms and that the risk for smoking to regulate affect is associated with higher levels of PTSD and ADHD symptoms. The overall aim of this Abstract Introduction: Smoking prevalence among individuals with posttraumatic stress disorder (PTSD) is elevated relative to non -PTSD smokers, and there is evidence to suggest that affect regulation may be a motivation for smoking among those with this disorder. Previous studies have also indicated that (a) PTSD is frequently comorbid with attention-defi cit/hyperactivity disorder (ADHD), (b) individuals with ADHD smoke at significantly higher rates than the general population, (c) subclinical ADHD symptoms are a risk factor for smoking, and (d) affect regulation is a motivation for smoking in ADHD. The goal of this study was to assess the degree to which ADHD symptoms were uniquely associated with smoking-related affective functioning (SRAF) variables above and beyond the variance already explained by PTSD symptoms.
Methods:Smokers with ( n = 55) and without PTSD ( n = 68) completed measures assessing PTSD symptoms, ADHD symptoms, and SRAF.
Results:The PTSD group endorsed signifi cantly more severe levels of DSM-IV inattentive and hyperactive -impulsive ADHD symptoms. A series of hierarchical regressions among the entire sample indicated that, after accounting for PTSD symptoms, ADHD symptoms were associated with lower positive affect, higher negative affect, higher emotion dysregulation, higher anxiety sensitivity, and higher urges to smoke to i...