How is affective instability defined and measured? A systematic review

Marwaha, Steven; He, Zhimin; Broome, Matthew R.; Singh, Swaran P.; Scott, Jan; Eyden, Julie; Wolke, Dieter

doi:10.1017/s0033291713002407

Cited by 133 publications

(138 citation statements)

References 94 publications

(69 reference statements)

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“…To our knowledge, there is no study that has compared adult ADHD patients with BD patients from the perspective of emotional dysregulation (Marwaha et al, 2014). Our results show that emotional dysregulation in ADHD is nearly as important in terms of emotional lability and greater in terms of emotional responsiveness than in BD.…”

Section: Discussionmentioning

confidence: 60%

“…To our knowledge and to date, there was no study comparing adult ADHD patients to bipolar disorder ones from the perspective of emotional dysregulation (Marwaha et al, 2014). This approach is also interesting to better understand the mechanisms which could be involved in such disturbances.…”

Section: Discussionmentioning

confidence: 99%

“…Dimensions are considered in terms of disruptions of the normalrange operation of one specific neural circuit resulting in dysfunctions of varying degrees (Marwaha et al, 2014). As suggested by Brome and al.…”

Section: Discussionmentioning

confidence: 99%

“…However, as the Affective Lability Scale (ALS) (Harvey et al, 1989) and the Affect Intensity Measure (AIM) (Flett et al, 1988;Diener, 1985, 1986;Mathieu et al, 2014) are the most commonly used scales to assess emotional dysregulation in borderline and in bipolar patients, diseases in which emotional dysregulation is particularly salient (Marwaha et al, 2014), we decided to choose these scales for our study to assess this dimension. Although these two scales examine different aspects of emotional dysregulation, responsiveness for the AIM and lability for the ALS, they are strongly correlated: the higher the lability, the higher the responsiveness, and inversely .…”

Section: Introductionmentioning

confidence: 99%

“…Although these two scales examine different aspects of emotional dysregulation, responsiveness for the AIM and lability for the ALS, they are strongly correlated: the higher the lability, the higher the responsiveness, and inversely . For patients suffering from ADHD, emotional lability, as measured by the ALS, has only been studied by one group (Skirrow and Asherson, 2013;Skirrow et al, 2014), while the degree of emotional responsiveness measured by the AIM has never been examined (Marwaha et al, 2014). Our aim is therefore to assess emotional dysregulation among subjects suffering from ADHD, by comparison with subjects suffering from BD and control subjects, with a focus on two dimensions: emotional lability (ALS) and emotional responsiveness (AIM).…”

Section: Introductionmentioning

confidence: 99%

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Similarities between emotional dysregulation in adults suffering from ADHD and bipolar patients

Richard-Lepouriel

Étain²,

Hasler

et al. 2016

Journal of Affective Disorders

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a b s t r a c tBackground: Emotional dysregulation in subjects with attention deficit and hyperactivity disorder (ADHD) is a topic of growing interest among clinicians and researchers. The present study aims at investigating components of emotional dysregulation in adults ADHD compared to subjects suffering from bipolar disorder (BD). Methods: A total of 150 adults ADHD, 335 adults BD subjects and 48 controls were assessed using the Affective Lability Scale (ALS) and the Affect Intensity Measure (AIM), measuring respectively emotion lability and emotion responsiveness. Results: ADHD and BD subjects scored significantly higher on the ALS compared to controls (p¼0.0001). BD subjects scored above ADHD ones (3.07 (SD¼0.66) vs. 2.30 (SD¼ 0.68); po0.0001). The average total scores achieved on the AIM were significantly different for the three groups (p¼0.0001) with significantly higher scores for ADHD subjects compared to BD ones (3.74 (SD¼ 0.59) vs. 3.56 (SD¼0.69); po0.0001). Limitations: Suspected cases of ADHD in the BD and control groups were derived from the Wender Utah Rating Scale (WURS). This study is a retrospective one. Conclusion: Our study thus highlights the importance of emotional dysregulation in adults suffering from ADHD, showing that they display higher emotional intensity than bipolar disorder subjects and controls. Although the current diagnostic criteria of ADHD do not contain an emotional dimension, a better recognition of the significance of emotional responsiveness in ADHD patients can improve the care afforded to these patients, beyond the inattentive and hyperactive/impulsive components.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Similarities between emotional dysregulation in adults suffering from ADHD and bipolar patients

Richard-Lepouriel

Étain²,

Hasler

et al. 2016

Journal of Affective Disorders

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The shared genetic basis of mood instability and psychiatric disorders: A cross‐trait genome‐wide association analysis

Hindley

O’Connell

Rahman

et al. 2022

American J of Med Genetics Pt B

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Recent genome-wide association studies of mood instability (MOOD) have found significant positive genetic correlation with major depression (DEP) and weak correlations with other psychiatric disorders. We investigated the polygenic overlap between MOOD and psychiatric disorders beyond genetic correlation to better characterize putative shared genetic determinants. GWAS summary statistics for schizophrenia (SCZ, n = 105,318), bipolar disorder (BIP, n = 413,466), DEP (n = 450,619), attention-deficit hyperactivity disorder (ADHD, n = 53,293), and MOOD (n = 363,705) were analyzed using the bivariate causal mixture model and conjunctional false discovery rate methods. MOOD correlated positively with all psychiatric disorders, but with wide variation in strength (r g = 0.10-0.62). Of 10.4 K genomic variants influencing MOOD, 4 K-9.4 K influenced psychiatric disorders. Furthermore, MOOD was jointly associated with DEP at 163 loci, SCZ at 110, BIP at 60 and ADHD at 25. Fifty-three jointly associated loci were overlapping across two or more disorders, seven of which had discordant effect directions on psychiatric disorders. Genes mapped to loci associated with MOOD and all four disorders were enriched in a

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Fluctuations of consciousness, mood, and science: The interhemispheric switch and sticky switch models two decades on

Miller

2020

J of Comparative Neurology

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Science and medicine aim to identify verifiable and replicable truths. However, the paths to such truths are frequently characterized by swinging pendulums of opposing perspectives. This is especially so in human neuroscience and the brain-based clinical sciences, where the target of investigation is the most complex of all biological systems. This article overviews a set of interrelated neuroscientific and clinical hypotheses, models, experiments, and predictions with which I have been involved for the last two decades. Traversing visual neuroscience, consciousness science, genetics, chronobiology, and biological and clinical psychiatry, the work illustrates how developments in science and medicine can occur through a combination of synthesis, serendipity, and experimentation. The article also reflects on doing science with the inimitable John "Jack" Pettigrew, and outlines how Pettigrew and I conceived, proposed, tested, and developed two new scientific models-one on neural mechanisms of binocular rivalry, the other on the pathophysiology of bipolar disorder. I also provide an update on various aspects of our models and data, and describe lessons learned from Pettigrew on how perspectives in science exhibit their own fluctuations, ironically like the very phenomena on which we worked.

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How is affective instability defined and measured? A systematic review

Abstract: 34Background: Affective instability (AI) is poorly defined but considered clinically important.

Cited by 133 publications

References 94 publications

Similarities between emotional dysregulation in adults suffering from ADHD and bipolar patients

Similarities between emotional dysregulation in adults suffering from ADHD and bipolar patients

The shared genetic basis of mood instability and psychiatric disorders: A cross‐trait genome‐wide association analysis

Fluctuations of consciousness, mood, and science: The interhemispheric switch and sticky switch models two decades on

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