Emodin extends lifespan of <i>Caenorhabditis elegans</i> through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1

Zhao, Xuan; Liu, Lulu; Qi, Yonghao; Li, Miao; Zhou, Lijun

doi:10.1080/09168451.2017.1365592

Cited by 30 publications

(23 citation statements)

References 37 publications

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“…The IIS pathway is a highly conservative and elaborate lifetime regulator, which plays a key role in development, metabolism, and aging in C. elegans [3]. This signaling pathway is activated by the translocation of DAF-16 to the nucleus [34]. The upregulation of daf-16 was combined with the downregulation of age-1 and activation of downstream target antioxidant genes sod-3 and gst-4 to pave the way for post-transcriptional exploration in the IIS pathway in the future.…”

Section: Discussionmentioning

confidence: 99%

Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

et al. 2020

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Orange, with various bioactive phytochemicals, exerts various beneficial health effects, including anti-cancer, antioxidant, and anti-inflammatory properties. However, its anti-aging effects remain unclear. In this study, the Caenorhabditis elegans (C. elegans) model was used to evaluate the effects of orange extracts on lifespan and stress resistance. The results indicated that orange extracts dose-dependently increased the mean lifespan of C. elegans by 10.5%, 18.0%, and 26.2% at the concentrations of 100, 200, and 400 mg/mL, respectively. Meanwhile, orange extracts promoted the healthspan by improving motility, and decreasing the accumulation of age pigment and intracellular reactive oxygen species (ROS) levels without damaging fertility. The survival rates of orange extract-fed worms were obviously higher than those of untreated worms against thermal and ultraviolet-B (UV-B) stress. Moreover, the activities of superoxide dismutase (SOD) and catalase (CAT) were significantly enhanced while malondialdehyde (MDA) contents were diminished. Further investigation revealed that worms supplemented with orange extracts resulted in upregulated levels of genes, including daf-16, sod-3, gst-4, sek-1, and skn-1, and the downregulation of age-1 expression. These findings revealed that orange extracts have potential anti-aging effects through extending the lifespan, enhancing stress resistance, and promoting the healthspan.

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Section: Discussionmentioning

confidence: 99%

Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

et al. 2020

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“…Single mutation of IIS genes such as daf-2, age-1, or daf-16 leads to inhibition of the IIS pathway and extension of lifespan (Uno and Nishida, 2016). In this review, most studies were found to be done on daf-2, daf-16, age-1, skn-1, hsf-1, and sir-2.1 genes, which are all 3 (Chaudhari and Kipreos, 2017) No data 20 • C Liquid E. coli OP50 (Zhao et al, 2017) 50 (Im et al, 2016) 40-50 (Bansal et al, 2015) 120 Table 2 continued 15 (Rathor et al, 2015) 80-100…”

Section: Resultsmentioning

confidence: 99%

Role of insulin/insulin-like growth factor-1 signaling pathway genes on the lifespan of Caenorhabditis elegans

Zulkefli

Shuid

Aan

2020

ijrps

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Aging process is influenced by the insulin/insulin-like growth factor-1 signaling (IIS) pathway or IGF-1 signaling pathway. Studies done on the genes of this pathway were found to affect longevity. However, no conclusive results have been drawn.The purpose of this systematic review is to summarize the function of genes involved in the IIS pathway of Caenorhabditis Elegans (C. elegans), a nematode commonly used as a model organism in molecular genetics and developmental biology. A literature search for relevant studies was done through PubMed and Scopus databases using MeSH keywords Caenorhabditis elegans, C. elegans, nematode, genes, RNA, DNA, IIS pathway, IGF pathway, lifespan, and longevity. The search was limited to studies that were published in the last ten years (2008-May 2018). After exclusion of duplicates, review papers, human, in vitro, and other organismal studies, a total of 76 research articles were selected for further assessments. Data relevant to the effects of IIS genes on the lifespan ofC. eleganswas independently extracted. Reduction of daf-2 and age-1 and overexpression of sir-2.1 were reported to promote increment of the lifespan of C. elegans. Furthermore, differentially expressed genes that were involved in the protection against oxidative stress, pathogen attack, and toxicity includeins-18, numr-1/-2, sgk-1, and rgs-1. The knockdown of daf-2, age-1, and overexpression of sir-2.1 genes prolonged the lifespan of C. elegans while knockdown of daf-16, hsf-1, sir-2.1 as well as skn-1 shorten the lifespan of C. elegans.In conclusion, the differential expression of genes in the IIS pathway prolongs the lifespan of C. elegans.

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“…Treatment with lowbush cranberry and essential oil alloaromadendrene failed to increase the lifespan of daf-16 mutants, indicating that a DAF-16/FOXO transcription factor is required but not Alaskan blueberry (Scerbak, Vayndorf, Hernandez, McGill, & Taylor, 2018;Yu et al, 2014). The protective effect of low-concentration arbutin against aging and oxidative stress was also dependent on DAF-16, indicating that arbutin-treated C. elegans exhibited increased resistance to stress (Zhou et al, 2017). Blueberry extract (BE) exerted no significant effect on the lifespan of daf-16 mutants, and the increased genetic expression level suggested that BE could promote daf-16 expression and then increase downstream sod-3 expression to extend lifespan and stress resistance (Wang, Liu, Li, & Liu, 2018).…”

Section: Daf-16mentioning

confidence: 98%

Potential ofCaenorhabditis elegansas an antiaging evaluation model for dietary phytochemicals: A review

Sun

2020

Comp Rev Food Sci Food Safe

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Aging is an inevitable process characterized by the accumulation of degenerative damage, leading to serious diseases that affect human health. Studies on aging aim to develop pre-protection or therapies to delay aging and age-related diseases. A preventive approach is preferable to clinical treatment not only to reduce investment but also to alleviate pain in patients. Adjusting daily diet habits to improve the aging condition is a potentially attractive strategy. Fruits and vegetables containing active compounds that can effectively delay the aging process and reduce or inhibit age-related degenerative diseases have been identified. The signaling pathways related to aging in Caenorhabditis elegans are evolutionarily conserved; thus, studying antiaging components by intervening senescence process may contribute to the prevention and treatment of age-related diseases in humans. This review focuses on the effects of food-derived extracts or purified substance on antiaging in nematodes, as well as the underlying mechanisms, on the basis of several major signaling pathways and key regulatory factors in aging. The aim is to provide references for a healthy diet guidance and the development of antiaging nutritional supplements. Finally, challenges in the use of C. elegans as the antiaging evaluation model are discussed, together with the development that potentially inspire novel strategies and research tools.

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Emodin extends lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1

Cited by 30 publications

References 37 publications

Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

Role of insulin/insulin-like growth factor-1 signaling pathway genes on the lifespan of Caenorhabditis elegans

Potential ofCaenorhabditis elegansas an antiaging evaluation model for dietary phytochemicals: A review

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