Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

Wang, Jing; Deng, Na; Wang, Hong; Li, Tong; Chen, Ling; Zheng, Bisheng; Liu, Rui Hai

doi:10.3390/molecules25020351

Cited by 56 publications

(44 citation statements)

References 45 publications

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“…GST acts as both antioxidant enzyme and conjugates sulfhydryl (–SH) with xenobiotics for onward detoxification and elimination (Mazzetti et al., 2015). Previous studies have also shown that tropical functional foods such as turmeric, ginger, soy, gingko biloba increased GST activity as one of their antioxidant properties (Niedzielska et al., 2016; Wang et al., 2020). Furthermore, this study also revealed an increase in catalase activity in flies fed with diets supplemented with the citrus peels.…”

Section: Discussionmentioning

confidence: 98%

Effect of citrus peels‐supplemented diet on longevity, memory index, redox status, cholinergic and monoaminergic enzymes inDrosophila melanogastermodel

et al. 2021

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This study sought to determine the life span promoting effecof orange (Citrus sinensis), tangerine (Citrus maxima) and grapefruit (Citrus paradisi) peels in Drosophila melanogaster model. Flies (both gender, 3 to 5 days old) were divided into seven (7) groups (n = 5) containing 40 flies each; group I (control) flies were fed with basal diet, II-VII were flies were fed with basal diet containing 0.1 and 1.0% of tangerine peel (TP), orange peel (CP), and grapefruit peel (GP) respectively, for 14 days. Locomotor performance and memory index were assessed via negative geotaxis and aversive phototaxis suppression assays, respectively. Thereafter, the fly homogenates were assayed for activities of acetylcholinesterase (AChE), monoamine oxidase (MAO) and antioxidant enzymes as well as other indices of their redox. The results revealed that the citrus peels significantly improved longevity, locomotor performance, memory index, antioxidant status, and modulate cholinesterase and monoamine oxidase enzyme activities in treated flies when compared to the control. The results obtained suggest that the citrus peels offer potentials as dietary supplement with life span promoting properties in D. melanogaster model which could as well serve as a functional food additives. Practical applications Citrus peels, although often considered agro-wastes, are used as food supplements and food ingredents especially in production of candies, jams and custards. This study suggests the use of orange (Citrus sinensis), tangerine (Citrus maxima), and grapefruit (Citrus paradisi) peels as dietary supplements which offers potential life span promoting properties.

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Section: Discussionmentioning

confidence: 98%

Effect of citrus peels‐supplemented diet on longevity, memory index, redox status, cholinergic and monoaminergic enzymes inDrosophila melanogastermodel

et al. 2021

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“…The effects of plant materials on gene regulation have been shown in numerous experiments on model organisms and cancer cell lines. It was shown that licorice and orange extract provoke enhancement of catalase activity and also extend Caenorhabditis elegans life span [ 85 , 86 ]. Citrus and apple pectin’s have induced the expression of genes involved in DNA repair ( D-Gadd, mei-9, spn-B ), apoptosis (wrinkled/hid) and heat shock response ( hsp70Aa ) in Drosophila [ 87 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the geroprotective effects of withaferin A in Drosophila melanogaster

Koval

Zemskaya

Aliper

et al. 2021

Aging

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Withanolides are a class of compounds usually found in plant extracts which are an attractive geroprotective drug design starting point. We evaluated the geroprotective properties of Withaferin A (WA) in vivo using the Drosophila model. Flies were supplemented by nutrient medium with WA (at a concentration of 1, 10, or 100 μM dissolved in ethanol) for the experiment group and 30 μM of ethanol for the control group. WA treatment at 10 and 100 μM concentrations prolong the median life span of D. melanogaster’s male by 7.7, 9.6% (respectively) and the maximum life span (the age of death 90% of individuals) by 11.1% both. Also WA treatment at 1, 10 and 100 μM improved the intestinal barrier permeability in older flies and affected an expression of genes involved in antioxidant defense ( PrxV ), recognition of DNA damage ( Gadd45 ), heat shock proteins ( Hsp68, Hsp83 ), and repair of double-strand breaks ( Ku80 ). WA was also shown to have a multidirectional effect on the resistance of flies to the prooxidant paraquat (oxidative stress) and 33° C hyperthermia (heat shock). WA treatment increased the resistance to oxidative stress in males at 4 and 7 week old and decreased it at 6 weeks old. It increased the male’s resistance to hyperthermia at 2, 4 and 7 weeks old and decreased it at 3, 5 and 8 weeks old. WA treatment decreased the resistance to hyperthermia in females at 1, 2 and 3 weeks old and not affected on their resistance to oxidative stress.

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“…Q3M is a avonoid abundant in onion peel that was found to extend the lifespan of C. elegans 39 . In the same study, even although rutin was found to improve the tolerance of C. elegans to oxidative stress, which is desirable for longevity , rutin had no affect the worm's lifespan 39 showed that orange extracts, where hesperidin was the predominant phenolic compound, increased the mean lifespan of C. elegans 43 . In the same study, orange extracts were also found to promote longevity by enhancing motility and reducing the accumulation of age pigment and ROS levels 43 .…”

Section: Flavonoidsmentioning

confidence: 96%

Random forest classification for predicting lifespan-extending chemical compounds

Kapsiani

Howlin

2021

Preprint

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Ageing is a major risk factor for many conditions including cancer, cardiovascular and neurodegenerative diseases. Pharmaceutical interventions that slow down ageing and delay the onset of age-related diseases are a growing research area. The aim of this study was to build a machine learning model based on the data of the DrugAge database to predict whether a chemical compound will extend the lifespan of Caenorhabditis elegans. Five predictive models were built using the random forest algorithm with molecular fingerprints and/or molecular descriptors as features. The best performing classifier, built using molecular descriptors, achieved an area under the curve (AUC) score of 0.815 for classifying the compounds in the test set. The features of the model were ranked using the Gini importance measure of the random forest algorithm. The top 30 features included descriptors related to atom and bond counts, topological and partial charge properties. The model was applied to predict the class of compounds in an external database, consisting of 1,738 small-molecules. The chemical compounds of the screening database with a predictive probability of ≥ 0.80 for increasing the lifespan of Caenorhabditis elegans were broadly separated into (i) flavonoids, (ii) fatty acids and conjugates, and (iii) organooxygen compounds.

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Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

Cited by 56 publications

References 45 publications

Effect of citrus peels‐supplemented diet on longevity, memory index, redox status, cholinergic and monoaminergic enzymes inDrosophila melanogastermodel

Effect of citrus peels‐supplemented diet on longevity, memory index, redox status, cholinergic and monoaminergic enzymes inDrosophila melanogastermodel

Evaluation of the geroprotective effects of withaferin A in Drosophila melanogaster

Random forest classification for predicting lifespan-extending chemical compounds

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