Emerging technologies for the prevention of dental caries. Are current methods of prevention sufficient for the high risk patient?

Bretz, Walter A.; Rosa, Odila Pereira da Silva

doi:10.1111/j.1875-595x.2011.00027.x

Cited by 9 publications

(8 citation statements)

References 23 publications

(22 reference statements)

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“…Similar results were not found for the placebo group. These results need to be put in perspective as a high number of restorations allows for rapid re-colonization of the mutans streptococci [12;13] and, therefore, had our study design been of a longer duration we are unsure if results presented here would have been extended for a longer period of time.…”

Section: Discussionmentioning

confidence: 99%

Effects of Typified Propolis on Mutans Streptococci and Lactobacilli: a Randomized Clinical Trial

Anauate-Netto

Marcucci

Paulino

et al. 2013

BDS

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Objective-The aim of this study was to determine in a randomized, double-blind, placebocontrolled clinical trial the effects of typified propolis and chlorhexidine rinses on salivary levels of mutans streptococci (MS) and lactobacilli (LACT).Methods-One hundred patients were screened for salivary levels of MS >100,000 CFUs/mL of saliva. All patients presented with at least one cavitated decayed surface. Sixty patients met entry criteria. Subjects were adults 18-55 years old. After restoration of cavitated lesions patients were randomized to 3 experimental groups: 1) PROP-alcohol-free 2% typified propolis rinse (n = 20); 2) CHX-0.12% chlorhexidine rinse; 3) PL-placebo mouthrinse. Patients rinsed unsupervised 15 mL of respective rinses twice a day for 1 min for 28 days. Patients were assessed for the salivary levels of MS (Dentocult SM) and LACT (Dentocult LB) at baseline, 7-day, 14-day, and at 28-day visits (experimental effects) and at 45-day visit (residual effects). General linear models were employed to analyze the data.Results-PROP was superior to CHX at 14-day and 28-day visits in suppressing the salivary levels of MS (p < .05). PROP was superior to PL at all visits (p < .01). The residual effects of PROP in suppressing the salivary levels of MS could still be observed at the 45-day visit, where significant differences between PROP and CHX (p < .05), were demonstrated. PROP was significantly superior than CHX in suppressing the levels of salivary LACT at the 28-day visit (p < .05).Conclusion-Typified propolis rinse was effective in suppressing cariogenic infections in caries-active patients when compared to existing and placebo therapies.

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Section: Discussionmentioning

confidence: 99%

Effects of Typified Propolis on Mutans Streptococci and Lactobacilli: a Randomized Clinical Trial

Anauate-Netto

Marcucci

Paulino

et al. 2013

BDS

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“…The differences in effectiveness of these different uoride salts has been the topic of much debate [71], but a systematic review concluded that they were equally effective [67]. No association between the three main types of fluoride salts present in toothpaste formulations and the magnitude of the treatment effect was recorded.…”

Section: -Fluoride Toothpastesmentioning

confidence: 98%

Topical Fluoride for Preventing Dental Caries in Children and Adolescents

Miller

Campus²,

Giuliana³

et al. 2012

CPD

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The use of topically applied fluoride has been widely researched as a means to reduce the risk of dental caries in conjunction with other treatment modalities (mechanical oral hygiene, dietary control, antimicrobial intervention, pit and fissure sealants). There is overwhelming evidence that reports not only the significance and importance of the use of fluoride as a caries-preventive agent, but also how safe fluoride application is when used appropriately, particularly in higher risk individuals and populations. This paper reviews the caries-protective benefits of topical fluoride application in children and adolescents, with an emphasis on the clinical efficacy and safety of the vehicles by which fluoride is topically delivered. Fluoride toothpaste represents today the most cost-effective fluoride-delivery system in the oral cavity and its use should be the centerpiece in all caries-preventive strategies. On the other hand, mouthrinses, gels and varnishes currently represent adjuncts to toothpaste use and should be targeted towards individuals and groups at high risk of caries.

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“…Se han formulado enjuagues bucales y geles que contienen P113, un fragmento ácido de Hst 3 para la prevención de la candidiasis y enfermedad periodontal; los ensayos en etapas preclínicas mostraron seguridad y efectividad 81 . Además se han descripto nuevas moléculas como los factores "trébol", secretados por las glándulas salivales y la mucosa bucal, considerados citoprotectores contra el daño celular y la respuesta inmune, por lo que se han empleado en formulaciones tópicas para reducir las molestias bucales asociadas a quimioterapia 82 . Otro campo de la biomedicina en la que estos péptidos naturales podrían tener aplicación en el futuro, es la implantología.…”

Section: Potenciales Usos Terapéuticos De Componentes Salivalesunclassified

Saliva: a pontential tool in Dentistry.

Barembarum¹,

Azcurra²

2019

RevFacOdont

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Saliva is a biological fluid of complex composition that facilitates the interactions between host cells, oral microorganisms and immune modulators with the main purpose of maintaining oral health status. Within the salivary components, proteins are fundamental, because they are responsible for the main functions of saliva. Proteomic studies contributed to identify and characterize between 2,000 and 2,600 different proteins and peptides in their composition. Among them, a high proportion is glycoproteins, such as mucins, proteins rich in proline and immunoglobulins, agglutinins, lactoferrin, cystatins and lysozyme. In addition, saliva possesses peptides of potent antimicrobial activity and protection to mineral tissues, such as cathelicidin LL-37, α and β defensins, histatins and statins. In particular, in recent years the selection of biomarkers of oral diseases such as dental caries, periodontal diseases and oral cancer has been focused, considering the simple, economical and non-invasive obtaining of this fluid, which has driven the development of technologies for the detection of biomarkers with high sensitivity and specificity for a wide variety of oral diseases. The study of the components of saliva and its potential biomarkers makes this fluid a powerful tool for diagnosis and detection of diseases, as well as to evaluate the evolution of therapeutic treatments, because it reflects the physiological and pathological state of the body.KEY WORDS: salivary proteins and peptides, biomarkers, dental caries, periodontal diseases, oral cancer ResumenLa saliva es un líquido biológico de composición compleja que facilita las interacciones entre las células del huésped, los microorganismos bucales y los moduladores inmunológicos con el principal propósito de mantener el estado de salud bucal. Dentro de los componentes salivales, las proteínas son fundamentales por ser responsables de las principales funciones de la saliva. Los estudios proteómicos contribuyeron a identificar y caracterizar entre 2.000 a 2.600 proteínas y péptidos diferentes en su composición. Entre ellas, una alta proporción son glucoproteínas, como las mucinas, proteínas ricas en prolina e inmunoglobulinas, aglutininas, lactoferrina, cistatinas y lisozima. Además la saliva posee péptidos de potente actividad antimicrobiana y de protección a los tejidos minerales, como la catelicidina LL-37, α y β defensinas, histatinas y estaterinas. En particular, en los últimos años se ha profundizado la selección de biomarcadores de las enfermedades bucales como caries dental, enfermedades periodontales y cáncer bucal, considerando la sencilla, económica y poco invasiva obtención de este fluido, por lo que se ha impulsado el desarrollo de tecnologías para la detección de biomarcadores con alta sensibilidad y especificidad para una gran variedad de enfermedades bucales. El estudio de los componentes de la saliva y sus potenciales biomarcadores convierte a este fluido en una potente herramienta de diagnóstico y detección de enfermedades, como así también para eval...

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Emerging technologies for the prevention of dental caries. Are current methods of prevention sufficient for the high risk patient?

Cited by 9 publications

References 23 publications

Effects of Typified Propolis on Mutans Streptococci and Lactobacilli: a Randomized Clinical Trial

Effects of Typified Propolis on Mutans Streptococci and Lactobacilli: a Randomized Clinical Trial

Topical Fluoride for Preventing Dental Caries in Children and Adolescents

Saliva: a pontential tool in Dentistry.

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