Emergence of nosocomial Mycobacterium massiliense infection in Goiás, Brazil

Cardoso, Alessandra Marques; Sousa, Eduardo Martins de; Viana-Niero, Cristina; Bortoli, Fernando Bonfim de; Neves, Zilah Cândida Pereira das; Leão, Sylvia Cardoso; Junqueira-Kipnis, Ana Paula; Kipnis, André

doi:10.1016/j.micinf.2008.09.008

Cited by 75 publications

(95 citation statements)

References 26 publications

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“…All of the obtained sequences were highly similar to the rpoB sequence of Mycobacterium massiliense CCUG 48898 (GenBank accession AY593981.2) and had two base substitutions (GenBank accession EU117207) (Leão et al 2010). A total of 152 isolates obtained from surgical patients in different states belonged to a single strain and showed two closely related pulsed field gel electrophoresis (PFGE) patterns with a one-band difference when using either DraI or AseI restriction enzymes (Cardoso et al 2008, Duarte et al 2009, Leão et al 2010. This strain was classified as M. abscessus subsp.…”

mentioning

confidence: 88%

Rapid tests for the detection of the Mycobacterium abscessus subsp. bolletii strain responsible for an epidemic of surgical-site infections in Brazil

Matsumoto

Chimara

Ramos

et al. 2012

Mem. Inst. Oswaldo Cruz

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confidence: 88%

Rapid tests for the detection of the Mycobacterium abscessus subsp. bolletii strain responsible for an epidemic of surgical-site infections in Brazil

Matsumoto

Chimara

Ramos

et al. 2012

Mem. Inst. Oswaldo Cruz

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“…The NTM infection diagnosis may be difficult, nevertheless the greatest problem faced by health professionals is its treatment (31) . An important characteristic of these mycobacteria is resistance to medications used in the treatment of tuberculosis (11) . It is worth noting that the clone BRA100 of M. massiliense, predominant in Brazil, is sensitive in vitro to amicacina, claritromicina and tigecycline but resistant to doxycycline and ciprofloxacin, and has intermediate sensitivity to cefoxitin and imipenem (8) .…”

Section: Nonrandomized Experimentsmentioning

confidence: 99%

“…There are few cases of NTM infections published in Brazil, such as studies addressing keratitis due to M. Chelonae after surgery to correct myopia (9) , skin infections due to M. abscessus and M. fortuitum after applications in mesotherapy or cosmetic surgery (10) and studies addressing the increasing risk of infections caused by these species of mycobacteria in patients undergoing invasive medical procedures (11) . Hence, there seems to be an underreported distribution concerning the occurrence of NTM associated with surgeries in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Micobactérias não tuberculosas em cirurgias: desafio passível de enfrentamento no Brasil?

Cabral¹,

Andrade

2011

Acta paul. enferm.

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Infections caused by nontuberculous mycobacteria (MNT) represent an epidemiological and health emergency, especially in patients undergoing invasive procedures. Based on these, we aimed to analyze the scientific evidence, the scientific literature, on the occurrence in Brazil of MNT infections in surgical patients. We used as a research method integrative review of the literature using the databases Lilacs, Medline/Pubmed, ISI Web of Science and the Cochrane Library. We selected 15 publications on this theme from the last 30 years that were directed at methods of prevention and control, with a focus on post-discharge surveillance, the use of antibiotics and glutaraldehyde. Eye surgery, cosmetic, heart, laparoscopic and arthroscopic procedures were the most commonly investigated. The national situation of MNTs is concerning, especially when one recognizes the possibility of underreporting. Keywords: Mycobacteria, atypical; Surgical procedures operative; Mycobacterium infections atypical RESUMOInfecções por micobactéria não tuberculosa (MNT) representam uma emergência epidemiológica e sanitária, especialmente, em pacientes submetidos a procedimentos invasivos. Frente ao exposto, objetivou-se analisar as evidências científicas, na literatura científica, sobre a ocorrência no Brasil de infecções por MNT em pacientes cirúrgicos. Utilizou-se como método de pesquisa a revisão integrativa da literatura nas bases de dados Lilacs, Medline/Pubmed, ISI Web of Science e Biblioteca Cochrane. Foram selecionadas 15 publicações sobre a temática nos últimos 30 anos que estavam direcionadas às medidas de prevenção e controle com foco na vigilância pós-alta, no uso de antibioticoterapia e glutaraldeído. Cirurgias oftalmológicas, estéticas, cardíacas e procedimentos laparoscópicos e artroscópicos foram as mais investigadas. A situação nacional das MNTs é preocupante, ainda mais quando se reconhece a possibilidade de subnotificação. Descritores: Micobactérias atípicas; Procedimentos cirúrgicos operatórios; Infecções atípicas por Mycobacterium RESUMENLas infecciones por micobacteria no tuberculosa (MNT) representan una emergencia epidemiológica y sanitaria, especialmente, en pacientes sometidos a procedimientos invasivos. Frente a lo expuesto, se tuvo como objetivo analizar las evidencias científicas, en la literatura científica, sobre la ocurrencia en el Brasil de infecciones por MNT en pacientes quirúrgicos. Se utilizó como método de investigación la revisión integrativa de la literatura en las bases de datos Lilacs, Medline/Pubmed, ISI Web of Science y Biblioteca Cochrane. Se seleccionaron 15 publicaciones sobre la temática en los últimos 30 años que estaban orientadas a las medidas de prevención y control con foco en la vigilancia post alta, en el uso de antibioticoterapia y glutaraldehido. Cirugías oftalmológicas, estéticas, cardíacas y procedimientos laparoscópicos y artroscópicos fueron las más investigadas. La situación nacional de las MNTs es preocupante, aun más cuando se reconoce la posibilidad de subnotificación.

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“…These include at least the states of Distrito Federal, Espírito Santo, Goiás, Mato Grosso, Minas Gerais, Pará, Rio Grande do Sul, Rio de Janeiro e São Paulo states accounting for over 1000 cases 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Mycobacterium massiliense BRA100 strain recovered from postsurgical infections: resistance to high concentrations of glutaraldehyde and alternative solutions for high level disinfection

Lorena

Pitombo

Côrtes³

et al. 2010

Acta Cir. Bras.

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Purpose:To evaluate the minimum inhibitory concentration (MIC) of GTA against these microorganisms and alternative disinfectants for high-level disinfection (HLD). Methods: Reference mycobacteria and clinical M. massiliense strains were included in this study. Active cultures were submitted to susceptibility qualitative tests with GTA dilutions (ranging from 1.5% to 8%), and commercial orthophthaldehyde (OPA) and peracetic acid (PA) -based solutions, during the period of exposure as recommended by National Agency of Sanitary Surveillance for HLD. Results: All reference and M. massiliense non-BRA100 strains, recovered from sputum, were susceptible to any GTA concentration, OPA and PA solutions. M. massiliense BRA100 strains presented MIC of 8% GTA and were susceptible to OPA and PA. Conclusion: M. massiliense BRA100 strain is resistant to high GTA concentrations (up to 7%), which proves that this product is non-effective against specific rapidly growing mycobacteria and should be substituted by OPA or PA -based solutions for HLD. Key words: Mycobacterium Infections. Videolaparoscopy. Disinfection. Glutaraldehyde. RESUMOObjetivo: Avaliar a concentração mínima inibitória (CMI) de GTA frente a M. massiliense e a susceptibilidade a produtos alternativos para desinfecção de alto nível (DAN). Métodos: Cepas de M. massiliense de origem clínica e de referência foram incluídas no estudo. As culturas ativadas foram submetidas a testes qualitativos com diluições de GTA (de 1,5% a 8%) e com soluções comerciais de ortoftaldeído (OPA) ou ácido peracético (PA), utilizando os tempos de exposição recomendados pela Agência Nacional de Vigilância Sanitária para DAN. Resultados: Todas as cepas de referência e M. massiliense não-BRA100, obtida de escarro, foram susceptíveis às concentrações de GTA, e soluções de OPA e PA. As cepas de M. massiliense BRA100 apresentaram CMI de 8% para GTA e foram susceptíveis a OPA e PA. Conclusão: M. massiliense BRA100 é resistente a altas concentrações de GTA (até 7%), o que demonstra que esse composto não é eficaz, e deve ser substituído por OPA ou PA nos processos de DAN.

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Emergence of nosocomial Mycobacterium massiliense infection in Goiás, Brazil

Cited by 75 publications

References 26 publications

Rapid tests for the detection of the Mycobacterium abscessus subsp. bolletii strain responsible for an epidemic of surgical-site infections in Brazil

Rapid tests for the detection of the Mycobacterium abscessus subsp. bolletii strain responsible for an epidemic of surgical-site infections in Brazil

Micobactérias não tuberculosas em cirurgias: desafio passível de enfrentamento no Brasil?

Mycobacterium massiliense BRA100 strain recovered from postsurgical infections: resistance to high concentrations of glutaraldehyde and alternative solutions for high level disinfection

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