EMCA and DEEM as Michael Reagents Used in Organic Synthesis

Antimicrobial Properties of Some New Synthesized Benzothiazole Linked Carboxamide, Acetohydrazide, and Sulfonamide Systems

“…A good nucleofuge, alkoxy group, is attached to the double bond of AOE; therefore, the best examined reaction of these compounds is nucleophilic vinyl substituation ( SN Vin ) of the alkoxy group affording a replacement product, which as a rule undergoes cyclization involving one of the electron‐withdrawing groups of the initial AOE. Besides, the AOE can enter into cycloaddition by their double C═C bond and also can play the role of their own precursors . EMME ( 1 ) and Michael acceptors such as “alkoxyacrylic” derivatives were used in the synthesis of biologically active compounds.…”

“…“Oxacin” type antibacterials having quinoline and naphyridine structures are good examples . These Michael acceptors reacted with different nucleophiles to give cyclic, fused cyclic structures and related compounds . Treatment of bacterial infections by sulfonamides as synthetic antibiotics is still used today as a traditional treatment.…”

The Pseudo‐Michael Reaction of 2‐Hydrazinylidene‐1‐Arylimidazolidines with Diethyl Ethoxymethylenemalonate

“…Among various methods of synthesis of heterocyclic compounds, reactions of 1,4‐addition, such as Michael reaction, have a wide range of usage and practical importance. The Michael reaction is a nucleophilic addition of enolate or analogous anions to the carbon–carbon double bond of α,β‐unsaturated ketones, aldehydes, nitriles, or carboxylic acid derivatives . It is a method for alkylation of active methylene compounds .…”

“…The Michael reaction is a nucleophilic addition of enolate or analogous anions to the carbon–carbon double bond of α,β‐unsaturated ketones, aldehydes, nitriles, or carboxylic acid derivatives . It is a method for alkylation of active methylene compounds .…”

The gould-jacob type of reaction for the synthesis of novel pyrimidopyrrolopyrimidines: A comparison of classical heatingvssolvent free microwave irradiation

“…Many heterocyclic systems such as 1,8-naphthyridines, 2H-pyrido[1,2-a]pyrimidin-4-ones, pyrazolinones, pyrons, xanthyrones, guanidine derivatives, 1,2,4-triazoles, 3-oxo-1,2,6-thiadiazines, 8-oxoimidazo [1,2a]pyrimidines, 3H-pyrrolo [1,2-a]indol-3-one derivatives and 1H-1,4-benzodiazepines have been obtained using EMME as synthon [2]. EMME is widely used in push-pull alkane [3], 1,4-addition elimination [4], 1,4 addition [5], [3+2] cycloadditions [6], Diels-Alder reactions [8] and extensively reviewed as Michael reagent [7]. Dave et al [9,10] reported a novel route for the synthesis of pyrido [3,2-e]pyrimido [1,2c]pyrimidines and thieno[3,2-e]pyrimido[1,2-c]pyrimidines using the same synthon.…”