Antimicrobial Properties of Some New Synthesized Benzothiazole Linked Carboxamide, Acetohydrazide, and Sulfonamide Systems

Abstract

We report herein the interaction of diethylethoxymethylene malonate (1) with 2‐cyanomethylbenzothiazole (7) to give diethyl 2‐(2‐benzothiazole‐2‐(3H)‐ylidiene)‐2‐(cyano ethyl) malonate (8a) in excellent yield. Ethyl 4‐cyano‐1‐oxo‐1H‐benzo[4,5]thiazolo[3,2‐a]pyridine‐2‐carboxylate (9) was synthesized from 8a and subjected to react with hydrazine hydrate to give its corresponding acid hydrazide 10. Condensation of 10 with different acid anhydrides afforded the corresponding benzothiazolo pyridine carboxamide derivatives 11–15. In addition, we report a simple synthesis of N′‐(benzo[d]thiazol‐2‐yl)‐2‐((4‐ayl)amino)acetohydrazide derivative (17), which then reacted with different amines to give the corresponding acetohydrazide derivatives 19a–c. Moreover, compound 17 reacted with some sulfonamide derivatives to give the corresponding sulfonamide derivatives 20 and 22a,b.The newly synthesized compounds were established their structures on the bases of their correct analytical and spectral data and evaluated their antimicrobial activity. It was found that compounds 22a,b displayed the highest antimicrobial activity against the tested organisms.

A Compendium of the Most Promising Synthesized Organic Compounds against Several Fusarium oxysporum Species: Synthesis, Antifungal Activity, and Perspectives

“…Fadda et al (2019) reported another set of benzothiazole analogs following the same narrative of screening hybrid compounds to inhibit some microorganisms [ 131 ]. They described the synthesis through a linear sequence of some novel derivatives involving pyrimidine, thiazole, and phthalimide rings linked to the benzothiazole core.…”

Synthesis and antiproliferative evaluation of some novel quinazolin‐4(3H)‐one derivatives

“…The quinazolinone core is found in both natural products and in pharmaceuticals, representing a privileged scaffold exhibits wide spectrum of therapeutic activities such as antiproliferative, [ 1,2 ] antiinflammatory, [ 3,4 ] antidiabetic, [ 5 ] antimicrobial, [ 6 ] antibacterial, [ 2,7 ] antifibrotic, [ 8 ] anticoagulant, [ 9 ] antioxidant, [ 10 ] anticonvulsant, [ 11 ] antituberculosis, [ 12 ] antifungal, [ 13 ] antiviral, [ 14 ] antimalarial, antihypertensive, [ 15 ] and CNS depressant. [ 16 ]…”