“…Only 1 (ICU-based) study 28 was a randomized clinical trial. Eight studies [24][25][26][27]29,30,32,33 used a beforeand-after observational design, with 6 studies 25,26,29,30,32,33 being prospective and 2 studies 24,27 being retrospective. The remaining 2 studies 1,31 were prospective case series.…”