Elicited soybean extract attenuates proinflammatory cytokines expression by modulating TLR3/TLR4 activation in high−fat, high−fructose diet mice

Atho'illah, Mochammad Fitri; Safitri, Yunita Diyah; Nur’aini, Farida Dewi; Widyarti, Sri; Tsuboi, Hideo; Rifa’i, Muhaimin

doi:10.1016/j.jaim.2021.01.003

Cited by 17 publications

(12 citation statements)

References 51 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The NFκB signaling pathway blockade may ameliorate the inflammatory condition by suppressing IL-1β expression. 32,33 The findings of this investigation showed that HW decreased IL-1 levels in DM rats after supplementation with HW, which was consistent with previous results. Furthermore, as the concentration of IL-1β decreased, the concentration of IL-10 increased.…”

Section: Hydrogen-rich Water Affected Glucose Level Body and Organ Weights In Diabetic Ratssupporting

confidence: 92%

Hydrogen-Rich Water Ameliorates Pancreatic Cell Necrosis and Regulates Cytokine Levels in Streptozotocin-Induced Diabetic Rats

2021

TJNPR

View full text Add to dashboard Cite

Water is a vital component for the body, especially for maintaining a healthy body and preventing various diseases. 1 Lack of water intake may lead to dehydration and increase the risk of various diseases such as headaches, urolithiasis, obesity, and diabetes mellitus. 1,2 According to Goodman, drinking more water is linked to a reduction in body weight. 2 Adequate water consumption is better than a fiber diet in a 24-week weight loss program in overweight and obese women. 3,4 Consumption of 1 L of water daily for three months and 0.8 L of water daily for six months significantly reduced fasting blood glucose. 5 More water intake can treat obesity. Adequate water consumption could affect the removal of excess glucose in the kidney by creating more urine. Dehydration is associated with an increase in blood glucose level caused by the inability to excrete glucose in the urine. 1 Diabetes mellitus (DM) is a metabolic disease that disrupts the metabolism of carbohydrates, fats, and proteins characterized by an increase in the normal level of blood glucose. 6 The prevalence of diabetes has increased over the decades. 7 Diabetic patients accounted for 463 million (9.3% of the world's population) in 2019, with ages ranging from 20 to 79 years, and this figure is anticipated to rise to 700 million (10.9%) by 2045. 7,8 The increasing prevalence of people with diabetes is also higher in low and middle-income countries compared with high-income countries. 9

show abstract

Section: Hydrogen-rich Water Affected Glucose Level Body and Organ Weights In Diabetic Ratssupporting

confidence: 92%

Hydrogen-Rich Water Ameliorates Pancreatic Cell Necrosis and Regulates Cytokine Levels in Streptozotocin-Induced Diabetic Rats

2021

TJNPR

View full text Add to dashboard Cite

show abstract

“…Gibb's free energy measures the amount of free energy generated from the binding affinity. The more negative the Gibb's free energy value, the greater the interaction between the ligand and the protein (Atho'illah et al, 2021;Pertami et al, 2021). The key residues of CCR5 are Tyr37 and Trp86, with the latter being an important residue for the inhibition of CCR5 (Lin et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Computational Study of Garlic Compounds as Potential Anti-Cancer Agents for the Inhibition of CCR5 and CXCR4

Balqis¹,

Lukiati²,

Amin³

et al. 2022

CMUJNS

Self Cite

View full text Add to dashboard Cite

Current cancer treatment methods are still inadequate due to the complexity of the cancer progression mechanism, which involves multiple genes, proteins, and signaling pathways. The discovery and validation of novel anticancer compounds remains challenging. Garlic has many medicinal properties that can combat various diseases. Organosulfur present in garlic has been shown to induce apoptosis in cancer cells; however, the underlying mechanism of action of non-organosulfur compounds from garlic in controlling cancer cells remains unclear. The present study aimed to analyze the efficacy of organosulfur and non-organosulfur compounds, including the flavonoid, terpenoid, and saponin groups, as inhibitors of C-C chemokine receptor type 5 (CCR5) and C-X-C chemokine receptor type 4 (CXCR4), which play significant roles in the progression of cancer. To determine the interactions between the active compounds of garlic and these receptors (CCR5 and CXCR4), molecular docking was performed using the PyRx v.0.8 software. Amino acid residues were analyzed and visualized using Biovia Discovery Studio and PyMol, respectively. Non-organosulfur compounds exhibited better results than the organosulfur compounds in binding affinity analysis. Tigogenin (from the saponin group) is considered to be a CCR5 inhibitor, while lupeol (from the terpenoid group) is considered to be a CXCR4 inhibitor. In conclusion, our results suggest that garlic compounds could be promising inhibitors of CCR5 and CXCR4, which are highly expressed in cancer. However, further research is needed to validate the in vitro and in vivo activities of garlic compounds for the inhibition of cancer progression. Keywords: Anticancer agents, CCR5, CXCR4, Garlic, Organosulfur compounds, Non-Organosulfur compounds]

show abstract

“…The cells' population was then according to the stained used for further analysis. Cell subsets analysis was performed using FlowJo v10 for Windows (FlowJo LLC, Ashland, OR), following the previously validated protocol [ 38 ].…”

Section: Methodsmentioning

confidence: 99%

Lactobacillus plantarum FNCC 0137 fermented red Moringa oleifera exhibits protective effects in mice challenged with Salmonella typhi via TLR3/TLR4 inhibition and down-regulation of proinflammatory cytokines

Wuryandari

Atho'illah

Laili

et al. 2022

Journal of Ayurveda and Integrative Medicine

View full text Add to dashboard Cite

Background Salmonella typhi is a foodborne pathogenic bacterium that threatens health. S. typhi infection exacerbated the antibiotic resistance problem that needs alternative strategies. Moringa oleifera possesses anti-inflammatory and antimicrobial effects. However, there is a lack of information about the pharmacological value of red M. oleifera . The fermentation of red M. oleifera leaves extract (RMOL) is expected to add to its nutritional value. Objective The present study aimed to evaluate non-fermented RMOL (NRMOL) and fermented RMOL (FRMOL) effects on S. typhi infection in mice. Materials and methods Female Balb/C mice were randomly divided into eight groups. The treatment groups were orally administered with NRMOL or FRMOL at doses 14, 42, and 84 mg/kg BW during the 28 days experimental period. Then S. typhi was introduced to mice through intraperitoneal injection except in the healthy groups. The NRMOL or FRMOL administration was continued for the next seven days. Cells that expressed CD11b + TLR3 + , CD11b + TLR4 + , CD11b + IL-6 + , CD11b + IL-17 + , CD11b + TNF-a + , and CD4 + CD25 + CD62L + were assessed by flow cytometry. Results Our result suggested that NRMOL and FRMOL extracts significantly reduced ( p < 0.05 ) the expression of CD11b + TLR3 + , CD11b + TLR4 + , CD11b + IL-6 + , CD11b + IL-17 + , and CD11b + TNF-α + subsets. In contrast, NRMOL and FRMOL extracts significantly increased ( p < 0.05 ) the expression of CD4 + CD25 + CD62L + subsets. NRMOL at dose 14 and 42 mg/kg BW was more effective compared to FRMOL in reducing the expression of CD11b + TLR3 + , CD11b + TLR4 + , and CD11b + TNF-α + subsets. Conclusion Our findings demonstrated that NRMOL and FRMOL extracts could be promising agents for protection against S. ty...

show abstract

Elicited soybean extract attenuates proinflammatory cytokines expression by modulating TLR3/TLR4 activation in high−fat, high−fructose diet mice

Cited by 17 publications

References 51 publications

Hydrogen-Rich Water Ameliorates Pancreatic Cell Necrosis and Regulates Cytokine Levels in Streptozotocin-Induced Diabetic Rats

Hydrogen-Rich Water Ameliorates Pancreatic Cell Necrosis and Regulates Cytokine Levels in Streptozotocin-Induced Diabetic Rats

Computational Study of Garlic Compounds as Potential Anti-Cancer Agents for the Inhibition of CCR5 and CXCR4

Lactobacillus plantarum FNCC 0137 fermented red Moringa oleifera exhibits protective effects in mice challenged with Salmonella typhi via TLR3/TLR4 inhibition and down-regulation of proinflammatory cytokines

Contact Info

Product

Resources

About