Elevation of serum adiponectin levels in Basedow disease

Saitô, Takako; Kawano, Takahisa; Saito, T.; Ikoma, Aki; Namai, Kazuyuki; Tamemoto, Hiroyuki; Kawakami, Masanobu; Ishikawa, San‐e

doi:10.1016/j.metabol.2005.05.011

Cited by 37 publications

(28 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Adipose tissue has TSH receptors, so TBII may cross-react with TSH receptors to influence adiponectin secretion. In Saito et al's study, thyroid-stimulating hormone-receptor antibody made the strongest contribution to serum-adiponectin concentrations in patients with Basedow disease [26]. Because all our patients had Graves' disease, we measured TBII in different thyroid-function status, but no apparent correlation was revealed.…”

Section: Disscussionsmentioning

confidence: 79%

Serum Concentrations of Adiponectin in Patients with Hyperthyroidism before and after Control of Thyroid Function

Hsieh

Wang

2008

Endocr J

View full text Add to dashboard Cite

Abstract. Objective: Thyroid hormone affects adipocyte function, which in turn influences lipid and carbohydrate metabolism. Adiponectin is one of the adipocytokines that regulates lipid and carbohydrate metabolism. The aim of our study was to evaluate circulating levels of adiponectin in patients with thyroid dysfunction before and after normalization of thyroid function with appropriate medication. Design & Methods: One hundred and twenty patients with hyperthyroidism were recruited at the time of diagnosis. Measurements of free T4 (FT4), thyroid-stimulating hormone (TSH), thyrotropin binding inhibitor immunoglobulin (TBII), adiponectin, fasting blood glucose, fasting serum insulin, lipid profile, and body mass index (BMI) were taken before and after 6 months of medical treatment, at which point all patients were in a euthyroid state. Results: Any change in BMI was strongly correlated with changes in serum-adiponectin levels (r = -0.789, p<0.001). Any change in serum FT4 was also correlated with changes in BMI and serum adiponectin levels (r = -0.254, p = 0.05 and r = 0.501, p = 0.029 respectively). After controlling for BMI changes, we found correlation also between serum FT4 and adiponectin (r = 0.29, p = 0.005). Multivariate-regression analysis still revealed BMI to be a statistically strong predictor for serum-adiponectin level (p<0.001). However, that analysis also revealed thyroid function level as another predictor (p = 0.029). Conclusions: Although BMI is the best predictor of adiponectin, that thyroid hormone might influence circulating levels of adiponectin. PATIENTS with disturbances of thyroid function often experience changes in metabolic parameters, body weight, food intake, and thermogenesis. Hyperthyroid patients lose weight despite an increase in appetite, consistent with the fact that thyroid hormones play a role in energy expenditure. Thyroid function also affects adipocyte function, which influences lipid and carbohydrate metabolism, and can induce insulin resistance [1][2][3]. Adipose tissue performs complex metabolic and endocrine functions. Adiponectin is one of the important adipocytokines synthesized and secreted by adipose tissue, and is involved in regulating metabolism. Adiponectin has been shown to circulate in inverse proportion to the degree of insulin resistance [4,5] and reduced adiponectin levels have been found in patients with insulin resistance. Therefore, adiponectin and thyroid hormones are both involved in the energy homeostasis. Soltys et al. showed that circulating adiponectin could influence synthesis of thyroid hormones, especially free T4 (FT4). The mechanism may be through the carboxyl terminal-globular structure of adiponectin using the gC1q receptor found in thyroid mitochondria [6]. Although it is clear that adiponectin and thyroid hormone might both play an important role in metabolic regulation, their kinship in this aspect remains unclear. The aim of this study, then, was to explore the relationship between these two hormones in body homeostasis after control...

show abstract

Section: Disscussionsmentioning

confidence: 79%

Serum Concentrations of Adiponectin in Patients with Hyperthyroidism before and after Control of Thyroid Function

Hsieh

Wang

2008

Endocr J

View full text Add to dashboard Cite

show abstract

“…In humans, hyperthyroidism has been associated with both similar [128,195] and elevated adiponectin concentrations [196], while experimental study with hyperthyroid rats found an increase in adiponectin serum concentration [133]. In agreement, some data shown that therapy to normalize hyperthyroidism significantly reduced circulating adiponectin levels [197]. In contrast Luvizotto et al [189] show that thyroid hormone, at the doses of 5 and 25 μg T3 / 100 g BW, diminishes adiponectin gene expression, suggesting that thyroid hormone modulates negatively adiponectin expression in calorie-restricted obese rats (Figure 4).…”

Section: Adiponectinmentioning

confidence: 80%

Obesity and Weight Loss: The Influence of Thyroid Hormone on Adipokines

Luvizotto¹,

Conde²,

Oliveira³

et al. 2012

Thyroid Hormone

View full text Add to dashboard Cite

“…12,13,14 The current study was undertaken to observe the association of leptin and adiponectin on TSH levels in hypothyroid patients.…”

Section: Methodsmentioning

confidence: 99%

Impact of Adipocytokines-Leptin and Adiponectin on Thyroid Stimulating Hormone among Hypothyroid Patients

et al. 2013

View full text Add to dashboard Cite

Background: Adipocytokines, secreted from the adipose tissues have profound effect on complex metabolic and endocrine functions. Among them, leptin and adiponectin are the most recognized molecules which influence body homeostasis and metabolism. Moreover, patients with thyroid disease usually exhibit disturbances of these metabolic activities. Thus adipocytokines and thyroid hormones may influence similar aspects of metabolic functions. Objective:The main objective of current study was to evaluate the association and impact of leptin and adiponectin on thyroid stimulating hormone (TSH) among hypothyroid patients. Materials and Methods: For the present study a total 350 individuals were enlisted, out of which 200 were hypothyroid patients and 150 age and sex matched healthy controls aged ≥ 12 years. The serum TSH, leptin and adiponectin concentration were measured by CLIA method and results were computed by statistical methods such as mean, standard deviation, standard error and correlation using MS-Excel 2007. Result: Our data showed that hypothyroidism was more prevalent in the age group 30-50(62%) and an elevated TSH level was observed with advancing age among the patients as compared to controls. The inverse relation of leptin and adiponectin has been seen among the patients. When patients were compared with controls, they were with normal values which were in the range of standardized lab values leptin (3.7-13ng/dl) and adiponectin (5-10µg/ml). Conclusion: In conclusion, our data interpreted variations in the level of leptin and adiponectin among the hypothyroid individuals with high TSH level. As abnormal levels of these adipocytokines indicates the risk for other metabolic diseases like cardiovascular disease, obesity etc. Leptin is a protein hormone encoded by the obesity gene (ob) acts as neurotransmitters to brain to maintain body weight. It is majorly produced from white adipose tissue, but can also be produced by other tissues like placenta, ovary, mammary epithelial cells, hypophysis, stomach, and liver. The normal level of leptin in female is 7-13ng/dl and in male is 1-5ng/dl. Its concentration increases in obesity, Type 2 diabetes mellitus, hypertension and metabolic syndrome.2 Whereas adiponectin is a unique adipokine secreted by adipocytes has anti-atherogenic, anti-inflammatory and insulin sensitizing properties. Clinically normal range of plasma adiponectin is 5-10µg/ml. Its concentration is decreased with obesity, non-insulin dependent diabetes mellitus insulin resistance and dyslipidaemia. 3Thyroid hormones are also crucial for the regulation of total energy consumption and body composition besides their roles in normal growth, development, and reproduction. The normal levels of these hormones i.e. T 3 , T 4 and TSH are in the range of 0.87-2nmol/L, 6.09-12.23nmol/L and 0.34-5.6µIU/L respectively. Hypothyroidism and hyperthyroidism are associated with thyroid dysfunction. Clinical presentations are most commonly for hypothyroid and goiters and infrequently for hyperthyroidism.

show abstract

Elevation of serum adiponectin levels in Basedow disease

Cited by 37 publications

References 32 publications

Serum Concentrations of Adiponectin in Patients with Hyperthyroidism before and after Control of Thyroid Function

Serum Concentrations of Adiponectin in Patients with Hyperthyroidism before and after Control of Thyroid Function

Obesity and Weight Loss: The Influence of Thyroid Hormone on Adipokines

Impact of Adipocytokines-Leptin and Adiponectin on Thyroid Stimulating Hormone among Hypothyroid Patients

Contact Info

Product

Resources

About