Obesity and Weight Loss: The Influence of Thyroid Hormone on Adipokines

Luvizotto, Renata de Azevedo Melo; Conde, Sandro José; Oliveira, Mauro Dal Secco de; Síbio, Maria Teresa De; Nagamati, Keize; Nogueira, Célia Regina

doi:10.5772/46179

Cited by 1 publication

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References 249 publications

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“…Several studies suggest the impact of leptin secreted from extra fat mass on TSH release (via weight-affecting hormones and neurotransmitters), increased deiodinase activity, and increased conversion of T4 to T3 [44]. The findings of some studies indicate that T3 modulates the gene expression, serum levels of leptin, resistin, and adiponectin in obesity [45, 46]. TSH also increases leptin production through its receptors in adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

“…They also regulate lipid metabolism by affecting the expression of lipolytic enzymes, increasing the consumption of oxygen, and altering the sensitivity of the tissue to other hormones. According to findings of some studies, the effect of thyroid hormones on the improvement of conditions caused by an increase in body fat percentage can be achieved through the body fat mass while increasing metabolism [45–52]. Viguerie et al [49] showed that 19 genes of human white adipose tissue are regulated by thyroid hormones.…”

Section: Discussionmentioning

confidence: 99%

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Association of thyroid hormones with resting energy expenditure and complement C3 in normal weight high body fat women

et al. 2019

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BackgroundA high body fat percentage has a specific effect on activation of the hypothalamic-pituitary-thyroid axis. On the other hand, a slight change in thyroid hormones can affect metabolism and body composition as well as immune function. This study aims to examine the relationship between adiposity, thyroid hormone levels and immunity by comparing resting energy expenditure (REE), serum thyroid hormone levels and complement C3 in normal-weight high body fat (normal weight obesity) women and normal-weight normal body fat women.MethodsIn this case-control study, 40 women with normal body weight (BMI < 24.9 kg/m2) and body fat mass (FM) ≥ 30% (normal-weight obesity (NWO) group), and 30 non-obese women (BMI < 24.9 kg/m2) and FM < 30% (non-normal weight obesity (non-NWO) group) were recruited from a sport club in Tehran. Body composition was analyzed using bioimpedance analyzer. Blood samples were collected and analyzed for fasting serum concentration of thyroid hormones (including total T3 and total T4), thyroid-stimulating hormone (TSH), and serum complement C3. REE was measured by an indirect calorimetry.ResultsSerum T3 and T4 and also complement C3 were higher in the NWO group than in the non-NWO group. Body fat percentages had significant positive correlation with T3 (r; 0.344, P < 0.05), T4 (r; 0.294, P < 0.05), and complement C3 (r; 0.417, P < 0.05). Serum T3 and T4 were also positively correlated with C3 concentration (r; 0.417, p < 0.001) and (r; 0.349, p < 0.05); respectively, but there was no significant correlation between TSH and C3. REE was not significantly different between the two groups. REE only had a significant positive correlation with fat-free mass (r; 0.421, P < 0.001).ConclusionAn increase in body fat even in the presence of a normal body weight can be accompanied by the changes in thyroid function and inflammatory markers such as complement C3.

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Section: Discussionmentioning

confidence: 99%