Elevated total and isoenzyme forms of acid phosphatase in falciparum malaria

Garba, I.; Gatsing, Donatien; Ubom, Gregory A.

doi:10.1016/j.crvi.2005.12.001

Cited by 12 publications

(8 citation statements)

References 19 publications

(18 reference statements)

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“…Increase in ROS and decrease in antioxidants has been reported in malaria patients [14][15][16]. The alterations in the major antioxidants of the erythrocytes and the peroxide lysis of the erythrocytes may result in release of enzyme like ACP [17]. Our results indicate that ACP levels are very highly increased in malaria patients where as Hb levels are decreased.…”

Section: Discussionsupporting

confidence: 64%

Acid Phosphatase as a Marker in Malaria

et al. 2011

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The serum acid phosphatase (ACP) activity and Hemoglobin (Hb) levels were measured in malaria patients and nonmalarial fever patients. The results were compared with normal healthy control subjects. ACP was significantly increased (P \ 0.001) in all the malaria patients. ACP was significantly higher in Plasmodium falcifarum malaria and mixed malaria when compared to Plasmodium vivax malaria. Hb levels were significantly decreased in all the malaria patients which indicates that malaria parasite uses host erythrocyte Hb as a major nutrient source. There is negative correlation(r = -0.478) between ACP and Hb in malaria patients, which is highly significant. These results suggest that the measurement of ACP could be used as a marker for malaria.

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Section: Discussionsupporting

confidence: 64%

Acid Phosphatase as a Marker in Malaria

et al. 2011

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“…Similar findings were noted by D'Souza B et al, Garba IH et al, Daniel E et al, Pratinidhi SA et al [4][5][6][7] It has been reported that the red blood cells contain an excess quantity of ACP. The cell membrane plays a central role in the growth and propagation of the malarial parasite in the blood.…”

Section: Discussionsupporting

confidence: 77%

“…[9][10][11] The alterations in the major antioxidants of the erythrocytes and the peroxide mediated lysis of the erythrocytes may result in release of enzymes like ACP. 5 …”

Section: Discussionmentioning

confidence: 99%

Serum acid phosphatase level - is it a marker for diagnosis of malaria

et al. 2017

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Background: Malaria is endemic throughout most of the tropics. Technically, detection of malaria parasite may be missed due to low parasite density at sampling time and poor blood film preparation. The study was aimed to evaluate the serum acid phosphatase levels as a possible diagnostic marker for malarial infections.Methods: This study was conducted on a total of 100 subjects (40 malaria cases, 30 non-malarial cases and 30 sex and age matched healthy controls attending the department of medicine, PESIMSR, Kuppam. Venous blood sample was collected and serum acid phosphatase (ACP) level estimation was be done by enzymatic method using commercial kit (Raichem diagnostics kit).Results: Serum ACP level was highly significantly elevated in malarial group (Mean±SD) (3.14±1.22) when compared with control (1.33±0.72) and non-malarial (1.81±0.30) groups (P value <0.001.).Conclusions: In this study, there was a significant increase in the serum ACP levels in malarial patients as compared to other groups. This suggests that serum ACP levels can be used as a marker for malaria.

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“…Our study also shows statistically significant decrease in heamoglobin (Hb) levels between the malarial and non-malarial fever patients. Similar findings were also noted by D'Souza B et al, Kanwar G et al, Garba IH et al, Pratinidhi SA et al [6,7,14,15] .…”

Section: R -Opo 3 +Acceptor --------R -Oh + Acceptor-posupporting

confidence: 78%

Study of Acid Phosphatase and Heamoglobin Level in Malarial and Non Malarial Fever Patients

Sulya

Solanki

2018

APALM

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Background: Malaria is a mosquito borne disease. It is a major health hazard in India and other tropical countries. An estimated 198 million cases of malaria and 584 000 malaria deaths occurred in 2013. Acid phosphatase (ec 3.1.3.2, ACP) includes all the phosphatases with optimal activity below the pH of 7.0. ACP is present in lysosomes in all cells and exist extra-lysosomally in erythrocytes. Little is known about the levels of ACP in infectious diseases like malaria. So we undertook this study to know the Hb and ACP level in malarial patients.Methods: 60 subjects in the age group of 20 to 50 years were included in this study. These subjects were divided into 2 groups. Group 1 included 30 confirmed malaria fever patients. Group 2 included 30 non-malarial fever patients of same age & sex group. These selected subjects had no prostate problems, previous anaemia, or any other kind of bone disorder. Serum ACP was estimated using kit method Result:The serum ACP levels were significantly increased in malarial fever patients when compared with the non malaria fever patients (P=0.032). There is also statistical significant difference in the Hb levels between malarial and non-malarial fever patients Conclusion:Our results of increased levels of serum ACP and decreased Hb in malarial fever patients could be used as a marker for haemolysis & anemia. ACP may be used as an additional investigation in the diagnosis of malaria.

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Elevated total and isoenzyme forms of acid phosphatase in falciparum malaria

Cited by 12 publications

References 19 publications

Acid Phosphatase as a Marker in Malaria

Acid Phosphatase as a Marker in Malaria

Serum acid phosphatase level - is it a marker for diagnosis of malaria

Study of Acid Phosphatase and Heamoglobin Level in Malarial and Non Malarial Fever Patients

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