Elevated serum sialic acid in pregnancy.

Crook, M; Constable, Stefan H.; Lumb, P J; Rymer, Janice

doi:10.1136/jcp.50.6.494

Cited by 23 publications

(18 citation statements)

References 17 publications

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“…Furthermore, they suggest that GDM may be a window to investigate the interrelationships of the syndrome and inflammatory states. In further support of this possibility are the facts that the innate immune system is activated in pregnancy (16,22) and that pregnancy is associated with insulin resistance (23), fat deposition, and various metabolic syndrome components such as GDM, dyslipidemia, and hypertension.…”

Section: Statistical Analysesmentioning

confidence: 96%

“…This technique involves a coupled enzyme assay reaction, incorporating neuraminidase, N-acetylneuraminic acid aldolase, and pyruvate oxidase linked to a peroxidase dye system. The between batch coefficient of variation was ϳ3.8% or better (16). Glucose measurements were recorded using an enzymatic technique (14), and insulin was measured by radioimmunoassay (ICN Pharmaceuticals, Irvine, CA).…”

Section: Follow-up Assessmentmentioning

confidence: 99%

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Total Sialic Acid and Associated Elements of the Metabolic Syndrome in Women With and Without Previous Gestational Diabetes

et al. 2002

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OBJECTIVE -Inflammatory markers predict type 2 diabetes and relate to the metabolic syndrome. Gestational diabetes mellitus (GDM) predicts type 2 diabetes and may be part of this syndrome. To examine the association of inflammatory markers with GDM, we investigated total sialic acid (TSA) in women with and without previous GDM.RESEARCH DESIGN AND METHODS -All women with GDM and a random sample of women from one center of the Brazilian Study of Gestational Diabetes were invited to return 7 years after their index pregnancy. After an interview, an oral glucose tolerance test and anthropometry were performed. A total of 46 women with and 50 women without previous GDM completed the protocol.RESULTS -Mean TSA was significantly higher in women with (71.8 Ϯ 11.1 mg/dl) than without (67.5 Ϯ 9.8 mg/dl) previous GDM (P Ͻ 0.05). In a linear regression model, TSA was 4 mg/dl (P Ͻ 0.05) higher in women with previous GDM, after adjustment for BMI, fasting insulin sensitivity, and number of years spent in school. In a similar model, current 2-h plasma glucose levels were associated with higher TSA levels after adjustment for waist-to-hip ratio and the log of triglycerides. TSA was strongly correlated with individual components and aggregates (r ϭ 0.55, P Ͻ 0.001) of the metabolic syndrome.CONCLUSIONS -Increased TSA levels are associated with previous GDM and are strongly linked to the metabolic syndrome. These findings in young women suggest that a chronic mild systemic inflammatory response is an early feature of the metabolic syndrome and that GDM may be a window for its investigation.

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Section: Statistical Analysesmentioning

confidence: 96%

Section: Follow-up Assessmentmentioning

confidence: 99%

Total Sialic Acid and Associated Elements of the Metabolic Syndrome in Women With and Without Previous Gestational Diabetes

et al. 2002

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“…Breastfeeding participants had a higher frequency of developing disease within a year after delivery; however, the analyzed sample size was too small to draw conclusions. Reportedly, mean serum sialic acid concentration is signi cantly higher during pregnancy and decreases after delivery in healthy individuals [32]. A rapid decline in sialic acid concentration after delivery might trigger disease progression.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy in GNE Myopathy Patients: A Nationwide Repository Survey in Japan

Yoshioka

Miyasaka

Okubo

et al. 2020

Preprint

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Background: GNE myopathy is an autosomal recessive adult-onset distal myopathy. While a few case reports have described the progression of GNE myopathy during pregnancy, none have examined progression after delivery or obstetric complications. Objective: This study aimed to reveal maternal complications, newborn complications, and the impact of pregnancy on disease progression in GNE myopathy patients. Methods: We conducted a questionnaire survey on pregnancy, delivery, and newborns involving female GNE myopathy patients who are currently registered in a national registry in Japan.Results: The response rate for the questionnaire survey was 60.0% (72/120). Of the 72 respondents, 44 (61.1%) had pregnancy experience (average, 1.8 pregnancies; 53 pregnancies before onset and 28 after onset). The incidence of threatened abortion was 26.9% among post-onset pregnancies, which was higher compared to those of the general Japanese population (p=0.03). No other maternal or infant complications were commonly observed. Over 80% were unaware of changes in disease progression during pregnancy or after delivery, while 19.0% experienced disease exacerbation within a year after delivery. Six patients developed myopathy within a year after delivery, while none developed myopathy during pregnancy.Conclusions: There were no serious maternal or newborn complications, and subjective progression did not differ during or after delivery in the majority of GNE myopathy patients. However, our findings suggest the importance of considering the possibility of threatened abortion and disease progression after delivery.

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“…For example, serum sialic acid level increases with the progression of pregnancy compared with that in non-pregnant women [15]–[17]; uterine sialic acid concentration decreases upon ovariectomy in Indian langur monkeys, but increases upon ovarian hormones E2 or E2+P4 treatments [18]. NPL came to our attention from our microarray analysis of mouse periimplantation uterine luminal epithelium (LE) (GEO number: GSE44451).…”

Section: Introductionmentioning

confidence: 99%

Progesterone Receptor-Mediated Regulation of N-Acetylneuraminate Pyruvate Lyase (NPL) in Mouse Uterine Luminal Epithelium and Nonessential Role of NPL in Uterine Function

Xiao

Diao

et al. 2013

PLoS ONE

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N-acetylneuraminate pyruvate lyase (NPL) catalyzes N-acetylneuraminic acid, the predominant sialic acid. Microarray analysis of the periimplantation mouse uterine luminal epithelium (LE) revealed Npl being the most downregulated (35×) gene in the LE upon embryo implantation. In natural pregnant mouse uterus, Npl expression increased 56× from gestation day 0.5 (D0.5) to D2.5. In ovariectomized mouse uterus, Npl was significantly upregulated by progesterone (P4) but downregulated by 17β-estradiol (E2). Progesterone receptor (PR) antagonist RU486 blocked the upregulation of Npl in both preimplantation uterus and P4-treated ovariectomized uterus. Npl was specifically localized in the preimplantation D2.5 and D3.5 uterine LE. Since LE is essential for establishing uterine receptivity, it was hypothesized that NPL might play a critical role in uterine function, especially during embryo implantation. This hypothesis was tested in the Npl (−/−) mice. No significant differences were observed in the numbers of implantation sites on D4.5, gestation periods, litter sizes, and postnatal offspring growth between wild type (WT) and Npl (−/−) females from mating with WT males. Npl (−/−)xNpl (−/−) crosses produced comparable little sizes as that from WTxWT crosses. Comparable mRNA expression levels of several genes involved in sialic acid metabolism were observed in D3.5 uterus and uterine LE between WT and Npl (−/−), indicating no compensatory upregulation in the D3.5 Npl (−/−) uterus and LE. This study demonstrates PR-mediated dynamic expression of Npl in the periimplantation uterus and dispensable role of Npl in uterine function and embryo development.

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Elevated serum sialic acid in pregnancy.

Cited by 23 publications

References 17 publications

Total Sialic Acid and Associated Elements of the Metabolic Syndrome in Women With and Without Previous Gestational Diabetes

Total Sialic Acid and Associated Elements of the Metabolic Syndrome in Women With and Without Previous Gestational Diabetes

Pregnancy in GNE Myopathy Patients: A Nationwide Repository Survey in Japan

Progesterone Receptor-Mediated Regulation of N-Acetylneuraminate Pyruvate Lyase (NPL) in Mouse Uterine Luminal Epithelium and Nonessential Role of NPL in Uterine Function

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