Elevated serum levels of soluble interleukin 2 receptors in HIV infection: correlation studies with markers of cell activation

Lang, J. M.; Coumaros, G.; Levy, Sandra M.; Falkenrodt, A.; Steckmeyer, M.; Partisani, Marialuisa; Aleksijevic, A.; Lehr, L; Koehl, C.

doi:10.1016/0165-2478(88)90126-5

Cited by 19 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These patients also had T cell imbalance [10]. Lang et al [8] have similarly shown elevation of slL-2R levels in patients suffering from AIDS, who had a low blood T4 cell number. They suggested that B cells and monocytes might be responsible for production of sIL-2R in these patients.…”

Section: Discussionmentioning

confidence: 83%

Serum soluble interleukin-2 (IL-2) receptor levels in women with breast carcinoma and its correlation with IL-2 receptor expression on blood lymphocytes and lymphocytic infiltration within the tumour

Sharma

Saha

Shinghal

et al. 1991

Cancer Immunol Immunother

View full text Add to dashboard Cite

This study describes serum levels of soluble interleukin-2 receptor (sIL-2R) in 13 healthy women, 10 women with breast dysplasia and 37 patients with breast carcinoma. A difference was found between sIL-2R levels in normal women and cancer patients. sIL-2R increased with the advance in stage of cancer but the extent of increase fell from stage III to stage IV as compared to the change from stage II to stage III. Of the 15 patients who were followed after surgery and/or therapy, 10 (67%) showed a fall in the serum sIL-2R levels. A negative correlation was found between sIL-2R levels and lymphocytic infiltration only within the malignant tissue. These findings probably indicate that sIL-2R exerts an immunomodulatory effect on blood lymphocytes by preventing their infiltration into the tumour tissue. To our knowledge, this is the first report of its kind in immunology of breast carcinoma.

show abstract

Section: Discussionmentioning

confidence: 83%

Serum soluble interleukin-2 (IL-2) receptor levels in women with breast carcinoma and its correlation with IL-2 receptor expression on blood lymphocytes and lymphocytic infiltration within the tumour

Sharma

Saha

Shinghal

et al. 1991

Cancer Immunol Immunother

View full text Add to dashboard Cite

show abstract

“…Elevated levels of sIL-2R have been reported in measles (26), HTLV-1 (27), and HIV infections (28)(29)(30). Elevated levels of sCD8 have been reported in measles (26) and EpsteinBarr virus infections (23).…”

Section: Discussionmentioning

confidence: 99%

Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue.

Kurane¹,

Innis²,

Nimmannitya³

et al. 1991

J. Clin. Invest.

269

170

View full text Add to dashboard Cite

It has been reported that the severe complication of dengue virus infection, dengue hemorrhagic fever (DHF) is much more commonly observed during secondary dengue virus infections than primary infections. In order to elucidate the role of T lymphocytes in the pathogenesis of DHF, we attempted to determine whether T lymphocytes are activated in vivo during dengue virus infections, by examining the levels of soluble IL-2 receptor (sIL-2R), soluble CD4 (sCD4), soluble CD8 (sCD8), interleukin-2 (IL-2) and interferon-'y (IFN'y) in the sera of 59 patients with DHF and 41 patients with dengue fever (DF).The levels of sIL-2R, sCD4, sCD8, IL-2, and IFNy were significantly higher in the acute sera of patients with DHF than in the sera of healthy children (P < 0.001 for all markers). The acute sera of patients with DF contained higher levels of sIL-2R, sCD4, IL-2, and IFN-y than the sera of healthy children (P < 0.001 for sIL-2R, IL-2, and IFN-y; P < 0.05 for sCD4), but did not have elevated levels of sCD8. The levels of sIL-2R (P < 0.05), sCD4 (P < 0.001), and sCD8 (P < 0.001) were higher in DHF than in DF on days 3-4 after the onset of fever. The levels of IL-2 and IFN'y in patients with DHF were highest 1 d before defervescence. There were no significant differences in the levels of sIL-2R, sCD4, sCD8, IL-2, and IFNy among grades 1, 2, and 3 of DHF. These results indicate (a) T lympho-

show abstract

“…These include: i) the general state of immune activation (Allen et al 1990, Asher & Sheppard 1988, Bass et al 1992. Fahey et al 1990, Pantaleo et al 1990, Lang et al 1988, Sheppard et al 1991, rosenberg & Fauci 1993, which may favor productive infection of CD4' T lymphocytes that expand //; silu or migrate to the lymphoid tissue in the process of responding lo specific antigens or providing help to B cells or CD8^ T cells; ii) abnormal re-trafficking of lymphocytes through the lymphoid organs including those infected with HIV; in this regard, high levels of expression of IFN-j-, which has been recently shown to slow the exit of lymphocytes from lymph nodes (Westermann el al. 1993), have been detected in lymph nodes of HiV-infecled individuals (Graziosi et al, personal communication); iii) microenvironmental mechanisms (i.e.…”

Section: Stage Oe Dichotomy In Viral Burden and Replication Between Pmentioning

confidence: 99%

Role of Lymphoid Organs in the Pathogenesis of Human Immunodeficiency Virus (HIV) Infection

Pantaleo

Graziosi

Demarest

et al. 1994

Immunological Reviews

174

View full text Add to dashboard Cite

The pathogenic mechanisms of HIV disease are multifactorial and multi-phasic. The common denominator of the disease is the profound immunosuppression that occurs in the vast majority of infected patients. Studies in lymphoid tissues in HIV disease have provided considerable insight into the pathogenic processes involved from the earliest phases of infection through the advanced stages. Following primary infection, virus is disseminated throughout the body and seeds the lymphoid tissue where its replication is only incompletely suppressed and where a reservoir of virus is established. Extracellular virus is trapped within the FDC of the lymph node germinal centers and serves as a source of infection for cells which reside in or migrate through the lymph node throughout the course of infection even during the early and often prolonged asymptomatic period. Eventually, the architecture of the lymphoid tissue is destroyed, compounding the immune dysfunction that results from the depletion of CD4+ T cells. In this regard, the lymphoid tissue of LTNPs is relatively intact and viral burden and replication is considerably lower in the peripheral blood and lymph node mono-nuclear cells of LTNPs than in individuals whose disease progresses. Cytokines probably play a major role in the modulation of HIV expression in the milieu of the lymphoid tissue. Further understanding of the pathogenic mechanisms operative in the lymphoid tissues of HIV-infected individuals will have important implications in the design of therapeutic strategies involving both antiretroviral and immunomodulatory approaches.

show abstract

Elevated serum levels of soluble interleukin 2 receptors in HIV infection: correlation studies with markers of cell activation

Cited by 19 publications

References 26 publications

Serum soluble interleukin-2 (IL-2) receptor levels in women with breast carcinoma and its correlation with IL-2 receptor expression on blood lymphocytes and lymphocytic infiltration within the tumour

Serum soluble interleukin-2 (IL-2) receptor levels in women with breast carcinoma and its correlation with IL-2 receptor expression on blood lymphocytes and lymphocytic infiltration within the tumour

Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue.

Role of Lymphoid Organs in the Pathogenesis of Human Immunodeficiency Virus (HIV) Infection

Contact Info

Product

Resources

About