Serum soluble interleukin-2 (IL-2) receptor levels in women with breast carcinoma and its correlation with IL-2 receptor expression on blood lymphocytes and lymphocytic infiltration within the tumour

Sharma, Sadhna; Saha, Kunal; Shinghal, Rajesh; Malik, Gauri Bazaz

doi:10.1007/bf01756142

Cited by 23 publications

(16 citation statements)

References 16 publications

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“…Sharma et at. [23] were unable to correlate sIL-2R levels with CD25 expression on lymphocytes in women with breasi cancer, but they found a significant negative correlation between this marker and lymphocytes within the lumours in this same group of patients. This indicates that sIL-2R exerts an immunomodulatory effect on blood lymphocytes by preventing their inlihration into the tumour tissue.…”

Section: Discussionmentioning

confidence: 70%

Evaluation of serum levels of tumour necrosis factor-alpha (TNF-α) and soluble IL-2 receptor (sIL-2R) and CD4, CD8 and natural killer (NK) populations during infrared pulsed laser device (IPLD) treatment

Santana-Blank¹,

Castes²,

Rojas³

et al. 1992

Clinical and Experimental Immunology

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SUMMARY The purpose of this study was to evaluate serum levels of TNF‐α, sIL‐2R and distribution of peripheral leucocyte subsets in patients with advanced neoplastic disease undergoing IPLD treatment. Fifteen cancer patients with evidence of persistent disease were further divided in two groups according to outcome at the end of the period of clinical evaluation: group 1 patients were still alive and group 2 patients had died. Our results show: (i) an increase in the initial level of TNF‐α in both groups; (ii) a decrease in TNF‐α levels during the follow up of group I patients; (iii) a significant increase in serum levels of sIL‐2R in patients in group 2 compared with those in group 1; (iv) a progressive and constant increase in TNF‐α levels in group 2; (v) a decrease in CD4+CD45RA+ subpopulation in both groups; (vi) an increase in CD25+ cells; (vii) an increase in CD4+, CD4+ CD45RA+ and CD25+ cells during the follow up of group 2 patients. The data generated here form the basis for further investigations on the use of IPLD as a single agent and in combination with other biological response modifiers in cancer patients.

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Section: Discussionmentioning

confidence: 70%

Evaluation of serum levels of tumour necrosis factor-alpha (TNF-α) and soluble IL-2 receptor (sIL-2R) and CD4, CD8 and natural killer (NK) populations during infrared pulsed laser device (IPLD) treatment

Santana-Blank¹,

Castes²,

Rojas³

et al. 1992

Clinical and Experimental Immunology

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“…are elevated in a variety of inflammatory and neoplastic disorders including myocardial infarction, Lyme disease, neonatal sepsis, myasthenia gravis, rheumatoid arthritis, small cell lung cancer, colon cancer, breast cancer, and ovarian cancer [140][141][142][143][144][145][146][147][148][149]. Soluble IL-2 receptor levels have also been reported to be elevated in those who attempted suicide and in patients after surgery [150,151].…”

Section: Soluble Receptors As Markers Of Diseasementioning

confidence: 99%

Soluble receptors in human disease

Heaney

Golde

1998

Journal of Leukocyte Biology

155

132

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“…High serum concentrations of sIL-2Ra or MMP-9 are correlated with adverse prognosis in patients with colorectal cancer, breast cancer and melanoma [20][21][22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Soluble interleukin-2 receptor and metalloproteinase-9 expression in head and neck cancer: prognostic value and analysis of their relationships

Agueznay

Badoual

Hans

et al. 2007

Clinical and Experimental Immunology

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SummaryIn a series of 84 head and neck patients, a statistically significant correlation was observed between high serum soluble interleukin (IL)-2 receptor alpha (sIL-2Ra) (P = 0·034) and metalloproteinase-9 (MMP-9) concentrations (P = 0·036) at diagnosis and a shorter survival of these patients. As MMP-9 has been shown to mediate cleavage of IL-2Ra (CD25) by preactivated T cells, we looked for a relationship between MMP-9 expression and soluble IL-2Ra serum concentrations in these cancer patients. We did not find any correlation between intratumoral expression of MMP-9 or serum MMP-9 concentrations and serum sIL-2Ra levels. These results led us to reassess the role of MMP-9 in the release of sIL-2Ra. Treatment of Kit225 leukaemic cells with recombinant MMP-9 slightly decreased membrane CD25 expression and was associated with an increased concentration of sIL-2Ra in the supernatants. However, using a selective inhibitor of MMP-9 we did not succeed in specifically inhibiting the release of sIL-2Ra by the Kit225 cell line or by phytohaemagglutinin (PHA)-activated peripheral blood mononuclear cells. In addition, in a preclinical mouse model, basal serum sIL-2Ra concentrations and sIL-2Ra production by activated cells were not altered in MMP-9-deficient mice compared to wild-type mice. Interestingly, a broad spectrum metalloproteinase inhibitor inhibited the release of sIL-2Ra by PHAactivated peripheral blood mononuclear cells, suggesting that in contrast with current views concerning the major role of MMP-9 in the cleavage of membrane IL-2Ra, other proteases are involved in the shedding of sIL-2Ra. MMP-9 and sIL-2Ra appear therefore as independent prognostic markers in head and neck cancers.

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Serum soluble interleukin-2 (IL-2) receptor levels in women with breast carcinoma and its correlation with IL-2 receptor expression on blood lymphocytes and lymphocytic infiltration within the tumour

Cited by 23 publications

References 16 publications

Evaluation of serum levels of tumour necrosis factor-alpha (TNF-α) and soluble IL-2 receptor (sIL-2R) and CD4, CD8 and natural killer (NK) populations during infrared pulsed laser device (IPLD) treatment

Evaluation of serum levels of tumour necrosis factor-alpha (TNF-α) and soluble IL-2 receptor (sIL-2R) and CD4, CD8 and natural killer (NK) populations during infrared pulsed laser device (IPLD) treatment

Soluble receptors in human disease

Soluble interleukin-2 receptor and metalloproteinase-9 expression in head and neck cancer: prognostic value and analysis of their relationships

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