1994
DOI: 10.1111/j.1600-065x.1994.tb00867.x
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Role of Lymphoid Organs in the Pathogenesis of Human Immunodeficiency Virus (HIV) Infection

Abstract: The pathogenic mechanisms of HIV disease are multifactorial and multi-phasic. The common denominator of the disease is the profound immunosuppression that occurs in the vast majority of infected patients. Studies in lymphoid tissues in HIV disease have provided considerable insight into the pathogenic processes involved from the earliest phases of infection through the advanced stages. Following primary infection, virus is disseminated throughout the body and seeds the lymphoid tissue where its replication is … Show more

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Cited by 174 publications
(110 citation statements)
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“…the virus positive yet antibody negative plasma is called the "acute stage" of the HIV infection. The part of the active viremia which is not detectable, and the period prior to the active viremia, when the virus reside in the mucosal membranes of the gut (Brenchley and Douek 2008;Mestecky et al 2009), in lymph nodes (Pantaleo et al 1994;Schacker 2008), macrophages in the lung and other tissues (Orenstein 2001), is termed the eclipse period. …”
Section: Detection Of Virus In the Bloodmentioning
confidence: 99%
“…the virus positive yet antibody negative plasma is called the "acute stage" of the HIV infection. The part of the active viremia which is not detectable, and the period prior to the active viremia, when the virus reside in the mucosal membranes of the gut (Brenchley and Douek 2008;Mestecky et al 2009), in lymph nodes (Pantaleo et al 1994;Schacker 2008), macrophages in the lung and other tissues (Orenstein 2001), is termed the eclipse period. …”
Section: Detection Of Virus In the Bloodmentioning
confidence: 99%
“…1,2 Specific phenotypes have been observed in the lymphoid organs, [1][2][3] lung, 4,5 kidney, 6,7 bone marrow, 8 striated muscle, 9 peripheral 10 and central 11,12 nervous system, and heart. 13 Cardiac disease in AIDS was under-appreciated early in the course of the epidemic, but is now recognized as one of the most frequent complications of infection with HIV-1.…”
mentioning
confidence: 99%
“…onocytes/macrophages represent a reservoir for HIV virus in infected individuals, because infection of these cells with HIV is not associated with cell death (1,2). Most macrophage-tropic strains of HIV-1, also referred to as R5 strains, use the cell surface CD4 molecule as major receptor and CCR5 as entry coreceptor (3)(4)(5).…”
mentioning
confidence: 99%