Elevated Serum Levels of Interleukin-6, Interleukin-1β and Human Chorionic Gonadotropin in Pre-eclampsia

Kalinderis, Michail; Papanikolaou, Athanasios; Kalinderi, Kallirhoe; Ioannidou, E; Giannoulis, C; Karagiannis, Vasilis; Tarlatzis, Basil C.

doi:10.1111/j.1600-0897.2011.01019.x

Cited by 94 publications

(75 citation statements)

References 45 publications

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“…CXCR3 is preferentially expressed on Th1 cells and CCR4 on Th2 cells, thus further amplifying Th1 and Th2 immunity, respectively (27). Although several previous studies by us and by others have shown a Th1-like pattern of cytokines in preeclampsia, some of them have been rather small and in general they were not controlled for gestational age and cortisone treatment, commonly used in EOP (12,21,(29)(30)(31)(32). As other studies have failed to show differences in levels of cytokines between normotensive and pre-eclamptic pregnancies (20,33,34), the previous results are inconsistent.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of coagulation, inflammation and angiogenesis are independently associated with preeclampsia

Boij

Berg²,

Ernerudh

et al. 2012

Journal of Reproductive Immunology

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Section: Discussionmentioning

confidence: 99%

Biomarkers of coagulation, inflammation and angiogenesis are independently associated with preeclampsia

Boij

Berg²,

Ernerudh

et al. 2012

Journal of Reproductive Immunology

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“…Ez a sajátosság biztosítja a magzat egészséges fejlődését a kedvező immunológiai környezet kialakítása révén [20]. A praeeclampsiával szövődött terhességek-ben ugyanakkor a proinfl ammatorikus citokinek (IL-1β, IL-6, IL-8, TNF-α) magasabb szérumszintje fi gyelhető meg, amely az antiinfl ammatorikus citokinek csökkené-sével is együtt jár [21,22]. A proinfl ammatorikus citokinek fokozott termelődése valószínű, hogy kulcsfontossá-gú szerepet tölt be a praeeclampsia patofi ziológiájában [23].…”

Section: öSszefoglaló Közleményunclassified

A praeeclampsia pszichoszociális vonatkozásai

2015

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A praeeclampsia kialakulásához egyes esetekben pszichés faktorok is hozzájárulhatnak neuroendokrin és immunoló-giai mechanizmusok közvetítése révén, amelyek közül kiemelhető a hypothalamus-hypophysis-mellékvesekéreg tengely aktivitásának fokozódása és a proinfl ammatorikus citokinek szérumszintjének emelkedése. A praeeclampsia egyes pszichés zavarok előfordulását is megnöveli, a hosszan tartó hospitalizáció, a kontrollvesztés érzése, a koraszülés vagy a magzat egészségkárosodása következtében. Emellett a kórkép tartósan fennálló neurokognitív panaszokat okozhat, amelyek szintén negatívan befolyásolhatják az életminőséget. Tekintettel arra, hogy az anya rossz mentális állapota a terhesség kimenetelét és a magzat fejlődését egyaránt károsan befolyásolhatja, a praeeclampsiás nők számára a pszichológiai segítségnyújtás előnyös lehet. Orv. Hetil., 2015, 156(50), 2028-2034. Kulcsszavak: praeeclampsia, terhesség, depresszió, hypothalamus-hypophysis-mellékvesekéreg tengely, pszichoterápia Psychosocial aspects of preeclampsiaDistress conditions during pregnancy may contribute to the development of preeclampsia by altering functions of the neuroendocrine and immune systems, e.g. activation of the hypothalamic-pituitary-adrenal axis and increase in plasma proinfl ammatory cytokines. Preeclampsia may also precipitate mental health problems due to long-term hospitalization or unpredictable and uncontrollable events such as preterm labor and newborn complications. Besides, preeclampsia may induce persistent neurocognitive complaints with a negative impact on patients' quality of life. As growing evidence indicates that poor maternal mental health has an adverse effect on pregnancy outcome and fetal development, psychosocial interventions may be benefi cial for women with preeclampsia. Rövidítések 11β-HSD2 = 11-béta-hidroxiszteroid-dehidrogenáz-2 izoenzim; ACTH = adrenokortikotrop hormon; CRH = corticotropin releasing hormon; EMDR = eye movement desensitization and reprocessing; HPA = hypothalamus-hypophysis-mellékve-sekéreg tengely; PPD = postpartum depresszió; PTSD = poszttraumás stressz zavar; SNRI = (selective serotonin-norepinephrine reuptake inhibitor) szelektív szerotonin-noradrenalin visszavételgátló; SSRI = (selective serotonin reuptake inhibitor) szelektív szerotoninvisszavétel-gátló A praeeclampsia a terhességek 5-8%-ában fellépő súlyos szövődmény, amely hypertoniában, vizeletfehérje-ürítés-ben nyilvánul meg. Jellemzően a terhesség második vagy harmadik trimeszterében jelentkezik, és az anyai és magzati mortalitás és morbiditás egyik vezető oka világ szerte. A kórkép patogenezise nem teljesen tisztázott. A praeeclampsia kialakulásában a placentáció zavara fontos szerepet játszik a terhesség korai szakaszában [1]. A rossz vérellátású, ezáltal hypoxiás placenta olyan faktorokat

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“…12 Many researchers had found that the plasma level of IL-1β was elevated in preeclamptic women. 9,[13][14][15] And increased placental expression of IL-1β was also observed in several researches. 13 IL-1β is located in 70-110 kb region of chromosome 2q13-21, including 7 exons and 6 introns.…”

Section: Introductionmentioning

confidence: 99%

“…The serum level of inflammation cytokines, one kind of cytokines, such as IL-1β, IL-2, IL-6 and IFN-c had been found to be higher in women with PE than in normotensive pregnant women, [7][8][9] which leaded to harmful Th1 immunity, threatening pregnancy by generating cytotoxic factors that injured maternal endothelium, altered steroid hormones biosynthesis and affected other factors which were implicated in trophoblast invasion and maternal spiral artery remodeling. 10,11 The production of inflammatory cytokines is regulated by the cytokine gene, thus, the cytokines gene polymorphism may play a key role in the development of PE.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of the IL1-BETA-511T/C gene in pregnant women complicated with pre-eclampsia

Khadhim

Kaduim

Sawadi

2017

IMJ

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Objective Identify the association between single nucleotide polymorphisms (SNP) of IL-1 Beta and the onset and severity of the disease. Pre-eclampsia (PE) is a relatively common, systemic pregnancy disorder characterized by the development of concurrent hypertension (>140/90 mmHg) and proteinuria (>300 mg/24 h) at ≥20 weeks of gestation, that may also be associated with a myriad of other symptoms such as edema, headache, blurred vision, irritability, abdominal pain, and thrombocytopenia. Methods The extracted DNA was amplified for IL-1 Beta RFLP in 60 clinically diagnosed preeclampsia pregnant women and 60 normotensive pregnant women. For statistical significance, OR was measured and all data were processed by using SPSS. Results IL-1 Beta genotyping in PE pregnant women showed the following results TT genotype having 2.33 fold risk of having PE and etiological factor (0.57) while TC mutant genotype showed 1.125 fold risk of having PE etiological factor of (0.111), while homozygous CC genotype considered as protective genotype with protective factor of (0.674). T allele considered the etiological factor of (0.287) while C allele considered as protective allele with protective factor of (0.589). Conclusion IL-1 Beta T allele considered as significant risk factor for having preeclampsia. The presence of IL-1 Beta C alleles protects against having preeclampsia.

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Elevated Serum Levels of Interleukin-6, Interleukin-1β and Human Chorionic Gonadotropin in Pre-eclampsia

Abstract: Our results highlight the inflammatory origin of PE and reinforce the possible role of hCG in the complex aetiology of its pathogenesis.

Cited by 94 publications

References 45 publications

Biomarkers of coagulation, inflammation and angiogenesis are independently associated with preeclampsia

Biomarkers of coagulation, inflammation and angiogenesis are independently associated with preeclampsia

A praeeclampsia pszichoszociális vonatkozásai

Polymorphisms of the IL1-BETA-511T/C gene in pregnant women complicated with pre-eclampsia

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