Elevated serum hepatocyte growth factor/scatter factor levels in inflammatory lung disease.

Abstract

Hepatocyte growth factor/scatter factor (HGF/SF) plays an important role in tissue repair in liver and renal damage. The clinical significance of this growth factor in these diseases has also been reported. The lung is one of the major sources of HGF/SF; because of this, we investigated serum HGF/SF levels in 26 patients with inflammatory lung disease (15 with interstitial pneumonitis [IP], 11 with bacterial pneumonia [BP]) by enzyme-linked immunosorbent assay. As controls, we measured HGF/SF in the serum of 13 stable outpatients with chronic respiratory failure. All patients had no significant liver or renal dysfunction. Serum HGF/SF levels were significantly elevated in patients with IP (1.16 +/- 0.22 ng/ml) or BP (0.96 +/- 0.27 ng/ml) compared with those in the control subjects (0.29 +/- 0.03 ng/ml, both p < 0.01). Serum HGF/SF levels in 14 healthy subjects were also studied, and the results (0.30 +/- 0.02 ng/ml) were not remarkably different from those of the control subjects. There were no significant correlations between serum HGF/SF levels and C-reactive protein and lactate dehydrogenase. Serum HGF/SF levels in the surviving patients rapidly decreased with treatment, but they did not change in the patients who ultimately died. Our results demonstrate the clinical significance of serum HGF/SF level as a useful indicator of prognosis in inflammatory lung disease.

Overexpression of c-Met and CD44v6 Receptors Contributes to Autocrine TGF-β1 Signaling in Interstitial Lung Disease

“…HGF is one of the key factors produced by fibroblasts important in lung pathology (51). In patients with acute lung injury, elevated levels of HGF are found in both serum (52,53) and bronchoalveolar lavage fluid, suggesting its involvement in human lung repair (54). The biological influence of HGF is mediated through its specific receptor, the c-Met tyrosine kinase (55).…”

Use of an Electronic Nose To DiagnoseMycobacterium bovisInfection in Badgers and Cattle

“…The dashed line was added by the authors. (26), and hepatocyte growth factor/scatter factor (31). At this stage, it is not possible to determine precisely which volatiles are responsible for the sensor response.…”

Effect of thoracic irradiation on hepatocyte growth factor in rats lung and in bronchoalveolar lavage fluid of patients with thoracic malignancies

“…HGF reverted to baseline value 6 months after irradiation, concurrent with the disappearance of other symptomatic changes. As serum HGF in patients with lung diseases is reportedly higher [22], HGF is also thought to be one of the inflammation inducing cytokines in human lung. In fact, as HGF production is regulated by multiple factors, we think that these changes do not represent a direct induction of HGF by irradiation, but are the result of indirect and complicated pathways involving radiation lung injury.…”

“…Recently, some authors reported that HGF may also play an important role in lung injury and subsequent regeneration, i.e. HGF messenger ribonucleic acid (mRNA) and blood HGF activity were markedly induced and exogeneously and intravenously administered HGF enhanced regeneration of epithelial cells in the trachea after HCl injection [20][21][22].…”