Effect of thoracic irradiation on hepatocyte growth factor in rats lung and in bronchoalveolar lavage fluid of patients with thoracic malignancies

Yamazaki, Hideya; Takeuchi, Eiji; Jt, Tang; Fukushima, S; Inoue, Tomohisa; Shinkawa, K; Watanabe, Yoichi; Tanaka, Eiichi; Teshima, Takeo; Ozeki, S; Koizumi, Mitsuru; Ito, Mitsuya; Nakamura, Hiroyuki

doi:10.1183/09031936.97.10112539

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…HGF remained below detected levels throughout the examined period of examination in the plasma. Yamazaki et al [ 233 ] TGF-β Wistar Hsd/cpb Right lung X-ray/18 Gy 1, 4, 7, 10 d and 2–34 w PAI-1 bioassay Plasma No significant changes in levels of TGF-β were observed at Days 1, 4, 7, 1 0 or 14 after irradiation. The first increase was observed at 16 w, with a maximum at 20 w. Vujaskovic et al [ 234 ] IL-4 Fischer-344 Right lung X-ray/20 Gy 1, 7, 14, 21, 28, 56 and 84 d RNA assay + WB Lung tissue IL-4 mRNA was upregulated in the irradiated lung tissue.…”

Section: Cytokine Responses To Radiationmentioning

confidence: 99%

Cytokines and radiation-induced pulmonary injuries

Lierová

Jeličová

Němcová

et al. 2018

Journal of Radiation Research

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Radiation therapy is one of the most common treatment strategies for thorax malignancies. One of the considerable limitations of this therapy is its toxicity to normal tissue. The lung is the major dose-limiting organ for radiotherapy. That is because ionizing radiation produces reactive oxygen species that induce lesions, and not only is tumor tissue damaged, but overwhelming inflammatory lung damage can occur in the alveolar epithelium and capillary endothelium. This damage may result in radiation-induced pneumonitis and/or fibrosis. While describing the lung response to irradiation generally, the main focus of this review is on cytokines and their roles and functions within the individual stages. We discuss the relationship between radiation and cytokines and their direct and indirect effects on the formation and development of radiation injuries. Although this topic has been intensively studied and discussed for years, we still do not completely understand the roles of cytokines. Experimental data on cytokine involvement are fragmented across a large number of experimental studies; hence, the need for this review of the current knowledge. Cytokines are considered not only as molecular factors involved in the signaling network in pathological processes, but also for their diagnostic potential. A concentrated effort has been made to identify the significant immune system proteins showing positive correlation between serum levels and tissue damages. Elucidating the correlations between the extent and nature of radiation-induced pulmonary injuries and the levels of one or more key cytokines that initiate and control those damages may improve the efficacy of radiotherapy in cancer treatment and ultimately the well-being of patients.

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Section: Cytokine Responses To Radiationmentioning

confidence: 99%

Cytokines and radiation-induced pulmonary injuries

Lierová

Jeličová

Němcová

et al. 2018

Journal of Radiation Research

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“…HGF production is transiently suppressed in the irradiated area after irradiation. 18 In this study, it was also revealed that the biomarkers in blood were outperformed by those in BALF with regard to the screening efficiency for small pulmonary nodules. Although the sensitivity of VEGF, TGF-β and HGF in blood for screening small pulmonary nodules was rather considerable, its specificity appeared deficient in comparison.…”

Section: Discussionmentioning

confidence: 61%

“…The upregulation of these biomarkers signifies the development and/or metastasis of primary lung cancer. [9][10][11][12][13][14][15][16][17][18][19] Meanwhile, for the reason that histopathological specimen of small pulmonary nodules less than 8 mm is intractable to be obtained and biomarkers in peripheral blood of patients generally elevate at late stage of lung cancer, biomarkers in BALF seems to be a more appropriate manner to be adopted in preliminary screening procedure of small pulmonary nodules which usually suggest potential malignancy at early stage. 3,4,[20][21][22][23] Thus, we postulated that the level of IL-6, TNF-α, VEGF, TGFβ, HGF, as well as CEA in BALF may have some value in the screening process of patients with cancer-suspicious pulmonary nodules less than 8 mm.…”

Section: Introductionmentioning

confidence: 99%

The screening role of a biomarker panel in BALF among patients with cancer‐suspected pulmonary nodules less than 8 mm

Xiong

Ding

Xu³

et al. 2020

Clinical Respiratory J

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Background It is intractable to differentiate the malignancy from benignancy of cancer‐suspected pulmonary nodules less than 8 mm. Methods The patients with small pulmonary nodules less than 8 mm which were suspected to be primary lung cancer underwent bronchoscopy and bronchoalveolar lavage. The level of vascular endothelial growth factor (VEGF), transforming growth factor‐beta (TGF‐β) and hepatocyte growth factor (HGF) in bronchoalveolar lavage fluid (BALF) were assayed. Then, all patients underwent histopathological examination by means of surgical resection of nodules to determine their benignancy or malignancy. The nodules’ benignancy and malignancy suggested by the biomarker panel consisted of VEGF, TGF‐β and HGF in BALF were validated by the histopathological results to determine their screening efficiency. Results Among 405 patients with pulmonary nodules less than 8 mm, 252 and 153 were predicted to be malignant and benignant, respectively, by using the biomarker panel in BALF. Finally, 180 (71.4%) of 252 and 114 (74.5%) of 153 were validated to be truly malignant and benignant, respectively, according to the histopathological results. In a receiver operating characteristic curve analysis of screening efficiency for pulmonary nodules less than 8 mm, the results demonstrated that the AUC [0.807 (0.658‐0.882)] of the biomarker panel in BALF was higher compared with that [0.605 (0.433‐0.738)] of the biomarker panel in blood (P = .001). Conclusions For patients with cancer‐suspected pulmonary nodules less 8 mm, a biomarker panel of VEGF, TGF‐β and HGF in BALF demonstrated more eligible screening efficiency for the preliminary differentiation of malignancy from benignancy, by contrast with their level in blood as well as PET/CT.

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“…The HGF/MET axis is believed to contribute significantly to proliferation, metastasis, extracellular matrix remodeling, tumor cell survival, and angiogenesis associated with tumors [176,177,178]. MET , originally identified as a proto-oncogene [179,180], was found to be up-regulated in a variety of cancers, inducing its constitutive expression [181,182,183,184,185,186].…”

Section: Biological Functions Of Hgf and Its Isoformsmentioning

confidence: 99%

Hepatocyte Growth Factor Isoforms in Tissue Repair, Cancer, and Fibrotic Remodeling

2014

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Hepatocyte growth factor (HGF), also known as scatter factor (SF), is a pleotropic factor required for normal organ development during embryogenesis. In the adult, basal expression of HGF maintains tissue homeostasis and is up-regulated in response to tissue injury. HGF expression is necessary for the proliferation, migration, and survival of epithelial and endothelial cells involved in tissue repair in a variety of organs, including heart, lung, kidney, liver, brain, and skin. The administration of full length HGF, either as a protein or using exogenous expression methodologies, increases tissue repair in animal models of tissue injury and increases angiogenesis. Full length HGF is comprised of an N-terminal hairpin turn, four kringle domains, and a serine protease-like domain. Several naturally occurring alternatively spliced isoforms of HGF were also identified. The NK1 variant contains the N-terminal hairpin and the first kringle domain, and the NK2 variant extends through the second kringle domain. These alternatively spliced forms of HGF activate the same receptor, MET, but they differ from the full length protein in their cellular activities and their biological functions. Here, we review the species-specific expression of the HGF isoforms, their regulation, the signal transduction pathways they activate, and their biological activities.

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Effect of thoracic irradiation on hepatocyte growth factor in rats lung and in bronchoalveolar lavage fluid of patients with thoracic malignancies

Cited by 4 publications

References 25 publications

Cytokines and radiation-induced pulmonary injuries

Cytokines and radiation-induced pulmonary injuries

The screening role of a biomarker panel in BALF among patients with cancer‐suspected pulmonary nodules less than 8 mm

Hepatocyte Growth Factor Isoforms in Tissue Repair, Cancer, and Fibrotic Remodeling

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