Elevated Serum C-Reactive Protein Concentration in Bosnian Patients with Probable Alzheimer's Disease

Abstract

Studies indicate that inflammatory mechanisms may play an important role in the pathogenesis of Alzheimer's disease (AD). C-reactive protein (CRP), marker and mediator of inflammation, has been detected in lesions typical for the affected areas of AD brain. There have been conflicting reports on serum CRP concentration in AD. Scarce data exist on association of CRP and measures of adiposity in AD patients. Thus, we investigated serum CRP concentration in fifteen overweight institutionalized patients with probable AD and fifteen age-matched control subjects. Body mass index (BMI) and waist/hip ratio (WHR) were calculated for each subject included in the study. Age, systolic and diastolic blood pressure, BMI and WHR did not differ significantly between the two groups. Serum CRP concentration was significantly higher in patients with AD compared to controls (p < 0.0001). Although not significant, positive correlations between serum levels of CRP and BMI and WHR were found. Obtained results support the notion that low-grade inflammation is present in patients with AD. Absence of significant association between CRP and measures of total and central adiposity in overweight AD patients needs further investigation and explanation.

Low-grade systemic inflammation in patients with amyotrophic lateral sclerosis

“…This approach is not disease specific and can be easily applied to any sub-acute inflammatory disease. Similar to the observations in our current study on patients with ALS, CRP concentrations were found to be higher in patients with AlzheimerÕs disease compared with controls (21)(22)(23), and also in persons before clinical onset of dementia (24), although a very recent study showed on the contrary a more rapid cognitive decline in patients with AlzheimerÕs disease with lower CRP levels (25). a wrCRP value of less than 5 mg ⁄ l), but a sub-clinical systemic low-grade inflammatory process was revealed when these results were compared with our database of healthy individuals.…”

Potential therapeutic effect of nanobased formulation of rivastigmine on rat model of Alzheimer&#39;s disease

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C‐reactive protein and ageing

“…These results suggest a direct functional effect elicited by CRP and may be explanatory for, at least in part, the pathogenesis of Alzheimer's disease . However, data to support this are scarce, and a direct inference based on comparative CRP levels should not be made with respect to the pathogenesis of Alzheimer's disease …”