Low-grade systemic inflammation in patients with amyotrophic lateral sclerosis

Keizman, Daniel; Rogowski, Ori; Berliner, Shlomo; Ish‐Shalom, Maya; Maimon, Natalie; Nefussy, Beatrice; Artamonov, Irena; Drory, Vivian E.

doi:10.1111/j.1600-0404.2008.01112.x

Cited by 94 publications

(92 citation statements)

References 30 publications

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“…Regression tree analysis for censored data was used to find the best NLR cutoff value [26]. Patients without available data on their pretreatment NLR and those with a recent (Յ1 month) health event (e.g., fracture) or treatment (e.g., radiation, steroids) known to be associated with a change in blood count were excluded from the NLR analysis [26,31]. A univariate analysis (unadjusted) of the association between the pretreatment NLR (calculated by dividing the neutrophil count by the number of lymphocytes) and potential factors associated with PSA response and disease progression, including prior response to an antiandrogen, pretreatment PSADT, and disease extent [17], was performed using logistic regression for the response rate and the Cox regression model for the PFS time.…”

Section: Discussionmentioning

confidence: 99%

Pretreatment Neutrophil-to-Lymphocyte Ratio in Metastatic Castration-Resistant Prostate Cancer Patients Treated With Ketoconazole: Association with Outcome and Predictive Nomogram

et al. 2012

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Background. The neutrophil-to-lymphocyte ratio (NLR), an inflammation marker, is prognostic in several cancers. We assessed the association between the pretreatment NLR and outcome of patients with metastatic castrationresistant prostate cancer (mCRPC) treated with the CYP17 inhibitor ketoconazole.Methods. This was an international, retrospective study of 156 mCRPC patients treated with ketoconazole. The independent effect of the pretreatment NLR and factors associated with treatment outcome were determined by multivariate analysis.Results. Seventy-eight patients (50%) had a >50% decline in prostate-specific antigen (PSA). The median progression-free survival (PFS) time was 8 months. Excluded from the analysis were 23 patients without available data on their NLR and those with a recent health event or treat-

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Section: Discussionmentioning

confidence: 99%

Pretreatment Neutrophil-to-Lymphocyte Ratio in Metastatic Castration-Resistant Prostate Cancer Patients Treated With Ketoconazole: Association with Outcome and Predictive Nomogram

et al. 2012

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“…Other markers of inflammation are also abnormal in ALS. There is also evidence of low-level systemic inflammation with increased levels of C-reactive protein and ESR in patients with ALS compared to controls, with the levels correlating to disability as measured by the ALS functional rating scale [60]. All these studies demonstrate the presence of a systemic immune response in people affected by ALS.…”

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 69%

Inflammatory Mediators as Biomarkers in Brain Disorders

et al. 2013

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Abstract-Neurodegenerative diseases such as Alzheimer, Parkinson, amyotrophic lateral sclerosis, and Huntington are incurable and debilitating conditions that result in progressive death of the neurons. The definite diagnosis of a neurodegenerative disorder is disadvantaged by the difficulty in obtaining biopsies and thereby to validate the clinical diagnosis with pathological results. Biomarkers are valuable indicators for detecting different phases of a disease such as prevention, early onset, treatment, progression, and monitoring the effect of pharmacological responses to a therapeutic intervention. Inflammation occurs in neurodegenerative diseases, and identification and validation of molecules involved in this process could be a strategy for finding new biomarkers. The ideal inflammatory biomarker needs to be easily measurable, must be reproducible, not subject to wide variation in the population, and unaffected by external factors. Our review summarizes the most important inflammation biomarkers currently available, whose specificity could be utilized for identifying and monitoring distinctive phases of different neurodegenerative diseases.

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“…Two dimensional gel electrophoresis was used to study serum proteins in ALS subjects and found that components of complement C3 were increased compared to controls [95]. There is also evidence of low level systemic inflammation with increased levels of C reactive protein and ESR in subjects with ALS compared to controls, with the levels correlating the levels of disability as measured by the ALS functional rating scale [96]. All these studies demonstrate the presence of an immune response in subjects with ALS.…”

Section: Immune Abnormalities In Blood and Csf In Alsmentioning

confidence: 94%

The Role of Immune and Inflammatory Mechanisms in ALS

McCombe¹,

Henderson²

2011

CMM

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Amyotrophic lateral sclerosis (ALS) is a severe progressive neurodegenerative disease. The cause is unknown, but genetic abnormalities have been identified in subjects with familial ALS and also in subjects with sporadic ALS. Environmental factors such as occupational exposure have been shown to be risk factors for the development of ALS. Patients differ in their clinical features and differ in the clinical course of disease. Immune abnormalities have been found in the central nervous system by pathological studies and also in the blood and CSF of subjects with ALS. Inflammation and immune abnormalities are also found in animals with a model of ALS due to mutations in the SOD1 gene. Previously it has been considered that immune abnormalities might contribute to the pathogenesis of disease. However more recently it has become apparent that an immune response can occur as a response to damage to the nervous system and this can be protective.

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Low-grade systemic inflammation in patients with amyotrophic lateral sclerosis

Abstract: A systemic low-grade inflammation was detected in patients with ALS and correlated with their degree of disability. A heightened systemic inflammatory state is apparently associated with a negative prognosis in ALS.

Cited by 94 publications

References 30 publications

Pretreatment Neutrophil-to-Lymphocyte Ratio in Metastatic Castration-Resistant Prostate Cancer Patients Treated With Ketoconazole: Association with Outcome and Predictive Nomogram

Pretreatment Neutrophil-to-Lymphocyte Ratio in Metastatic Castration-Resistant Prostate Cancer Patients Treated With Ketoconazole: Association with Outcome and Predictive Nomogram

Inflammatory Mediators as Biomarkers in Brain Disorders

The Role of Immune and Inflammatory Mechanisms in ALS

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