Pretreatment Neutrophil-to-Lymphocyte Ratio in Metastatic Castration-Resistant Prostate Cancer Patients Treated With Ketoconazole: Association with Outcome and Predictive Nomogram

Keizman, Daniel; Gottfried, Maya; Ish‐Shalom, Maya; Maimon, Natalie; Peer, Avivit; Neumann, Avivit; Rosenbaum, Eli; Kovel, Svetlana; Пили, Роберто; Sinibaldi, Victoria J.; Carducci, Michael A.; Hammers, Hans J.; Eisenberger, Mario A.; Sella, Avishay

doi:10.1634/theoncologist.2012-0125

Cited by 86 publications

(65 citation statements)

References 39 publications

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“…Neutrophil/lymphocyte ratio was also identified as a prognostic factor, with greater significance than serum albumin level. This provides the first evidence for neutrophil/lymphocyte ratio as a prognostic factor among CRPC patients treated with docetaxel chemotherapy, though higher neutrophil/lymphocyte ratios have been correlated with poor prognosis among patients with hormone-naïve prostate cancer [35], as well as patients with CRPC treated with ketoconazole [36].…”

Section: Discussionmentioning

confidence: 79%

Risk factors for febrile neutropenia in patients receiving docetaxel chemotherapy for castration-resistant prostate cancer

Shiota

Yokomizo

Takeuchi

et al. 2014

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Purpose Docetaxel is a standard therapy for patients with castration-resistant prostate cancer (CRPC). However, docetaxel-associated adverse events (AEs) such as febrile neutropenia (FN) can impair quality of life and may become life-threatening. In this study, we clarified the AEs and risk factors associated with FN in clinical settings. Methods This study included 37 Japanese patients with CRPC who were treated with 70-75 mg/m 2 docetaxel and 10 mg prednisone every 3 or 4 weeks between 2008 and 2012. AEs, risk factors for FN, and the prognostic significance of several clinicopathological factors were analyzed. Results Hematological AEs of ≥grade 3 included neutrocytopenia in 36 patients (97.3 %), leukopenia in 24 patients (64.9 %), lymphopenia in 10 patients (27.0 %), and FN in 4 patients (10.8 %). In addition, severe nonhematological AEs included colonic perforation, interstitial pneumonia, and acute respiratory distress syndrome in 1 patient each. Severe lymphopenia was positively associated with the incidence of FN. Low serum albumin and low lymphocyte count were identified as possible pre-treatment risk factors, while severe lymphopenia was identified as a post-treatment risk factor. Conclusions Non-hematological AEs as well as substantial hematological AEs were recognized in the Japanese population treated with docetaxel chemotherapy against CRPC. Preand post-treatment lymphopenia and pre-treatment serum albumin should be considered in order to minimize the risk of FN when selecting patients with prostate cancer for docetaxel therapy, and when considering dose modifications, and the prophylactic use of granulocyte colony-stimulating factor.

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Section: Discussionmentioning

confidence: 79%

Risk factors for febrile neutropenia in patients receiving docetaxel chemotherapy for castration-resistant prostate cancer

Shiota

Yokomizo

Takeuchi

et al. 2014

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“…In a study on patients who underwent radical cystectomy due to invasive bladder tumor, NLR cut-off value was found to be 3,0 and patients with NLR values higher than this had a significantly lower recurrence-free survival (Hermanns et al, 2014) There is a limited number of studies on the relationship between NLR and prostate cancer in the literature (Keizman et al, 2012;Nuhn et al, 2013;Sonpavde et al, 2014;Sumbul et al, 2014). In a study conducted with the participation of 238 patients with castration resistant metastatic prostate cancer, patients with pre-docetaxel treatment NLR values lower than 3 responded better to treatment and had significantly higher total survival compared to patients with NLR values higher than 3 (Nuhn et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…There is a limited number of studies on the relationship between NLR and prostate cancer in the literature (Keizman et al, 2012;Nuhn et al, 2013;Sonpavde et al, 2014;Sumbul et al, 2014). The aim of this study is to research the importance of NLR in prediction of PSA recurrence after radical prostatectomy, which has not been reported so far.…”

Section: Introductionmentioning

confidence: 99%

Importance of Neutrophil/Lymphocyte Ratio in Prediction of PSA Recurrence after Radical Prostatectomy

Gazel¹,

Taştemur²,

Açıkgöz³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The aim of this study was to research the importance of the neutrophil to lymphocyte ratio (NLR) in prediction of PSA recurrence after radical prostatectomy, which has not been reported so far. Materials and Methods: The data of 175 patients who were diagnosed with localised prostate cancer and underwent retropubic radical prostatectomy was retrospectively examined. Patient pre-operative hemogram parameters of neutrophil count, lymphocyte count and NLR were assessed. The patients whose PSAs were too low to measure after radical prostatectomy in their follow-ups, and then had PSAs of 0,2 ng/mL were considered as patients with PSA recurrence. Patients with recurrence made up Group A and patients without recurrence made up Group B. Results: In terms of the power of NLR value in distinguishing recurrence, the area under OCC was statistically significant (p<0.001) .The value of 2.494 for NLR was found to be a cut-off value which can be used in order to distinguish recurrence according to Youden index. According to this, patients with a higher NLR value than 2.494 had higher rates of PSA recurrence with 89.7% sensitivity and 92.6% specificity. Conclusions: There are certain parameters used in order to predict recurrence with today's literature data.We think that because NLR is easy to use in clinics and inexpensive, and also has high sensitivity and specificity values, it has the potential to be one of the parameters used in order to predict biochemical recurrence in future.

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“…This inflammation may be caused by hypodynamic forces on vascular epithelial cell (LavinGomez et al, 2011;Roberto et al, 2003). Hypodynamic forces observed in ESRD may be due to changes in plasma protein ratio, oncotic pressure and electrolyte imbalance arising from kidney malfunction (Kato et al, 2012;Memoli et al, 2000).Low lymphocyte count in patients is a result of Neutrophillia (that was observedamong ESRD patients) and is an inflammatory response that inhibits immune system response by suppressing the activity of immune cells such as lymphocyte, activated T cells, and natural killer cells (Manal and Shaimaa, 2015;Keizman et al, 2012). In addition, lymphocyte adheres to the inflamed vascular epithelial cells (Pecoits-Filho et al, 2002) and their concentration is reduced in the peripheral blood system.…”

Section: Discusionmentioning

confidence: 99%

Correlation of lymphocyte count with serum calcium level and neutrophil-to-lymphocyte ratio in end stage renal disease patients undergoing hemodialysis in Adamawa State, Nigeria

Etim¹,

Emokpae²,

Medugu³

et al. 2017

Int. J. Med. Med. Sci.

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Low lymphocyte count in end stage renal disease (ESRD) patients receiving maintenance hemodialysis was documented. This study aims to correlate the levels of lymphocyte count with serum calcium level, and neutrophil-to-lymphocyte ratio (NLR) in ESRD patient receiving hemodialysis in Northeast Nigeria. Seventy eight (78) patients receiving hemodialysis and 75 clinically healthy subjects (control) participated in the present study. Full blood count and serum calcium level were determined by using a Sysmex XP-300 Hematology Analyzer and a Selectra Pro-S Chemistry Analyzer, respectively. The mean levels of lymphocyte count, packed cell volume, hemoglobin and serum calcium level were significantly lower (p<0.001), while neutrophil, and NLR values were significantly higher (p<0.001) in ESRD patients undergoing hemodialysis as compared to the healthy control subjects. Lymphocyte count was negatively correlated with NLR value (r=-0.341; 0.05) but positively with serum calcium (r=0.904; p<0.001). In end stage renal disease (ESRD) patient receiving hemodialysis, lymphocyte count was negatively correlated with NLR value and positively with serum calcium level.

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Pretreatment Neutrophil-to-Lymphocyte Ratio in Metastatic Castration-Resistant Prostate Cancer Patients Treated With Ketoconazole: Association with Outcome and Predictive Nomogram

Cited by 86 publications

References 39 publications

Risk factors for febrile neutropenia in patients receiving docetaxel chemotherapy for castration-resistant prostate cancer

Risk factors for febrile neutropenia in patients receiving docetaxel chemotherapy for castration-resistant prostate cancer

Importance of Neutrophil/Lymphocyte Ratio in Prediction of PSA Recurrence after Radical Prostatectomy

Correlation of lymphocyte count with serum calcium level and neutrophil-to-lymphocyte ratio in end stage renal disease patients undergoing hemodialysis in Adamawa State, Nigeria

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