C‐reactive protein and ageing

Abstract

SummaryIncreasing evidence shows that C-reactive protein (CRP) is not only an inflammatory biomarker but also an important risk factor associated with ageing-related diseases including cardiovascular disease, hypertension, diabetes mellitus, and kidney disease.Recent studies have demonstrated that CRP is pathogenic in a number of diseases including hypertensive cardiovascular and kidney complications, diabetic nephropathy, and acute and chronic kidney diseases. It is well known that CRP binds its receptor, CD32/CD64, to induce the process of inflammation by activating the NF-κB signalling pathway. In addition, CRP mediates tissue fibrosis in a number of cardiovascular and kidney diseases by activating TGF-β/Smad signalling via TGF-β1-dependent and independent mechanisms. Furthermore, CRP is able to activate mTOR signalling in the diabetic conditions. Our recent studies also revealed that CRP impairs cell regeneration by causing the G1 cell cycle arrest and promotes ageing via a Smad3-dependent

Age associated microbiome modulation and its association with systemic inflammation in a Rhesus Macaque Model

“…Increases in IL-6, IFNγ, and TNFα are expected as these are known inflammatory cytokines that act on a systemic level, promoting chronic inflammation that’s associated with age (25). Increased CRP and neopterin are indicative of an increased systemic immune activation inflammatory state in older animals (26, 27). Neopterin, a metabolite of GTP, is produced in macrophages upon stimulation by IFNg released by activated T cells indicating an ongoing immune system activation and inflammatory response in the older animals.…”

Comparative chemoreactome analysis of dexketoprofen, ketoprofen, and diclofenac

“…2) показало, что он может одновременно способствовать снижению и острого, и хронического воспаления. СРБ как один из белков ост-рой фазы секретируется под воздействием продуцируемого макрофагами ИЛ6, который затем стимулирует синтез СРБ и фибриногена печенью [16]. По данным хемореактомного анализа, декскетопрофен (но не молекулы сравнения) мо-жет ингибировать секрецию ИЛ6 в остеобластах линии MC3T3 (IC50=39±37 мкг/мл), что вызывает снижение уров-ня СРБ в плазме крови.…”

Aging mechanisms and intervention targets

“…A number of molecules dubbed as aging genes and longevity genes may be associated with the mechanisms of aging (Figure ), but their roles in physiological and pathological aging remain to be established. An example in the process of premature aging is C‐reactive protein (CRP) as an inflammatory risk factor to aging‐related diseases, including cardiovascular disease, hypertension, diabetes mellitus, and kidney disease (for reviews, see Tang in this issue). However, CRP may become pathogenic by binding to its receptor CD32/CD64, instigating inflammation via activating the NF‐κB signalling pathway and inducing tissue fibrosis via by activating TGF‐β/Smad signalling .…”

“…An example in the process of premature aging is C‐reactive protein (CRP) as an inflammatory risk factor to aging‐related diseases, including cardiovascular disease, hypertension, diabetes mellitus, and kidney disease (for reviews, see Tang in this issue). However, CRP may become pathogenic by binding to its receptor CD32/CD64, instigating inflammation via activating the NF‐κB signalling pathway and inducing tissue fibrosis via by activating TGF‐β/Smad signalling . Moreover, under diabetic conditions, CRP may induce the activation of mTOR ‐‐ a protein kinase that senses of and responds to multiple nutrient cues in regulating aging and longevity …”

“…However, CRP may become pathogenic by binding to its receptor CD32/CD64, instigating inflammation via activating the NF‐κB signalling pathway and inducing tissue fibrosis via by activating TGF‐β/Smad signalling . Moreover, under diabetic conditions, CRP may induce the activation of mTOR ‐‐ a protein kinase that senses of and responds to multiple nutrient cues in regulating aging and longevity …”