Elevated preoperative neutrophil–lymphocyte ratio predicts upgrading at radical prostatectomy

Özsoy, Mehmet; Moschini, Marco; Fajković, Harun; Seitz, Christian; Klatte, Tobias; Gust, Kilian M.; Briganti, Alberto; Karakiewicz, Pierre I.; Rouprêt, Morgan; Kramer, Gero

doi:10.1038/s41391-017-0015-8

Cited by 17 publications

(23 citation statements)

References 28 publications

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“…In our study, we found that increased ANC was helpful in differentiating the malignant disease from those benign ones. Similar to our results, a higher ANC has been reported to discriminate the malignant cases from the benign ones and to be related with the poorer prognosis [15][16][17][18].…”

Section: Discussionsupporting

confidence: 91%

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Predictive and prognostic value of preoperative complete blood count in prostate cancer

Ünal¹

2018

Ann Clin Anal Med

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Aim: The predictive and prognostic value of complete blood count (CBC) in different types of cancer has been frequently demonstrated in recent years. Prostate cancer is the second most common cancer in men worldwide and is one of the most leading causes of death. In our study, we sought to find out whether CBC parameters could distinguish patients with prostate cancer from patients with benign prostatic hyperplasia. Material and Method: Laboratory findings and histopathological findings of totally 93 patients were retrospectively re-evaluated. The absolute neutrophil count (ANC), the absolute lymphocyte count (ALC), platelet count, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV) values were noted. In patients with prostate cancer, pathological parameters such as prostate weight, tumor percentage, Gleason score perineural invasion, seminal vesicle involvement, apical and radial margin involvement, extra-prostatic extension were determined. Results: In our study, we found that ANC, NLR, PLR, and MPV were significantly different between patients with benign prostatic hyperplasia and with prostate cancer (p < 0.05). We found that ANC and MPV were much more successful in discriminating these patients (p < 0.001). We have shown that ANC has higher specificity and MPV value has higher sensitivity. However, we didn't find any correlation between blood parameters and pathological parameters in patients with prostate cancer. Discussion: Our study has shown that ANC, NLR, PLR, and MPV have the ability to discriminate malignant lesions from benign lesions. Although no correlation with pathologic parameters can be determined, we think that CBC might be evaluated as an auxiliary tool for prostate cancer diagnosis.

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Section: Discussionsupporting

confidence: 91%

“…In recent studies, NLR has been also suggested to be a marker which should be used for tumor upgrading [16]. Similar to our study, Gökçe et al [17] reported that NLR and ANC were significantly higher in patients with PCa compared to those with BPH.…”

Section: Discussionsupporting

confidence: 90%

Predictive and prognostic value of preoperative complete blood count in prostate cancer

Ünal¹

2018

Ann Clin Anal Med

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“…In humans, no markers equivalent to the mouse Gr1 marker exist, and human neutrophils are defined as CD14-/CD15 + /CD66b + /CD16 + . The neutrophil-lymphocyte ratio in peripheral blood is associated with a high Gleason score and the poor prognosis of men with prostate cancer [60,61]. The ratio is also a prognostic factor of abiraterone and docetaxel treatment in men with castration-resistant prostate cancer [62,63].…”

Section: Neutrophilsmentioning

confidence: 99%

Obesity, Inflammation, and Prostate Cancer

Fujita

Hayashi

Matsushita

et al. 2019

JCM

107

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The prevalence of obesity is increasing in the world, and obesity-induced disease, insulin-resistance, cardiovascular disease, and malignancies are becoming a problem. Epidemiological studies have shown that obesity is associated with advanced prostate cancer and that obese men with prostate cancer have a poorer prognosis. Obesity induces systemic inflammation via several mechanisms. High-fat diet-induced prostate cancer progresses via adipose-secretory cytokines or chemokines. Inflammatory cells play important roles in tumor progression. A high-fat diet or obesity changes the local profile of immune cells, such as myeloid-derived suppressor cells and macrophages, in prostate cancer. Tumor-associated neutrophils, B cells, and complements may promote prostate cancer in the background of obesity. Interventions to control systemic and/or local inflammation and changes in lifestyle may also be viable therapies for prostate cancer.

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“…Although murine neutrophils differ from human neutrophils in terms of surface markers and genetic diversity [43], evidence suggested that neutrophils play an important role in progression of human prostate cancers. The peripheral blood neutrophil-lymphocyte ratio is associated with a high Gleason score and a poor prognosis in early stage prostate cancer [44,45], and is also a prognostic factor for response to abiraterone and docetaxel treatment in late stage castration-resistant prostate cancer [46,47]. Other studies have shown that neutrophils in both peripheral blood and prostate are predictive factors for prostate biopsy results [48,49].…”

Section: Immune Cells and Intercellular Signaling Promoting Prostamentioning

confidence: 99%

Main Inflammatory Cells and Potentials of Anti-Inflammatory Agents in Prostate Cancer

Hayashi

Fujita

Matsushita

et al. 2019

Cancers

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Prostate cancer is the most common type of cancer and the leading cause of cancer deaths among men in many countries. Preventing progression is a major concern for prostate cancer patients on active surveillance, patients with recurrence after radical therapies, and patients who acquired resistance to systemic therapies. Inflammation, which is induced by various factors such as infection, microbiome, obesity, and a high-fat diet, is the major etiology in the development of prostate cancer. Inflammatory cells play important roles in tumor progression. Various immune cells including tumor-associated neutrophils, tumor-infiltrating macrophages, myeloid-derived suppressor cells, and mast cells promote prostate cancer via various intercellular signaling. Further basic studies examining the relationship between the inflammatory process and prostate cancer progression are warranted. Interventions by medications and diets to control systemic and/or local inflammation might be effective therapies for prostate cancer progression. Epidemiological investigations and basic research using human immune cells or mouse models have revealed that non-steroidal anti-inflammatory drugs, metformin, statins, soy isoflavones, and other diets are potential interventions for preventing progression of prostate cancer by suppressing inflammation. It is essential to evaluate appropriate indications and doses of each drug and diet.

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Elevated preoperative neutrophil–lymphocyte ratio predicts upgrading at radical prostatectomy

Cited by 17 publications

References 28 publications

Predictive and prognostic value of preoperative complete blood count in prostate cancer

Predictive and prognostic value of preoperative complete blood count in prostate cancer

Obesity, Inflammation, and Prostate Cancer

Main Inflammatory Cells and Potentials of Anti-Inflammatory Agents in Prostate Cancer

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